THERAPEUTIC DRUG MONITORING (TDM)

Abstract

Therapeutic drug monitoring specializes in the measurement of drug concentrations in biological fluids and may serve as a practical aid to clarify various conditions of unexpect response to chronic drug treatment. Briefly, its main purpose is to optimize and/or individualize dosage regimens to maintain efficient and safe drug therapy. This is acieved by maintaining serum/plasma drug concentrations within a target range (therapeutic range, therapeutic window), which is defined as the range of plasma drug concentrations that produce therapeutic effects with minimal risk of adverse responses/side or toxic effects. In this review, indications, practical applications as well as the clinical value and cost-effectiveness of therapeutic drug monitoring is discussed

Keywords

• Therapeutic drug monitoring, therapeutic range, therapeutic window, clinical pharmacology, clinical pharmacy

TEDAVİDE İLAÇ İZLEMİ

Öz

Therapeutic drug monitoring specializes in the measurement of drug concentrations in biological fluids and may serve as a practical aid to clarify various conditions of unexpect response to chronic drug treatment. Briefly, its main purpose is to optimize and/or individualize dosage regimens to maintain efficient and safe drug therapy. This is acieved by maintaining serum/plasma drug concentrations within a target range (therapeutic range, therapeutic window), which is defined as the range of plasma drug concentrations that produce therapeutic effects with minimal risk of adverse responses/side or toxic effects. In this review, indications, practical applications as well as the clinical value and cost-effectiveness of therapeutic drug monitoring is discussed.

Anahtar Kelimeler

• Terapötik ilaç izlemi, terapötik aralık, terapötik pencere, klinik farmakoloji, klinik eczacılık