Toll benzeri reseptörler

Mehmet Özbek; Mustafa Hitit; Emel Ergün; Feyzullah Beyaz; Levent Ergün

doi:10.24998/maeusabed.335529

Toll benzeri reseptörler

Abstract

Doğal bağışıklık polimorfnükleer lökosit, monosit, makrofaj, eozinofil granülosit, mast hücresi ve bazofil granülüsit gibi özelleşmiş hücrelerden ve moleküllerden meydana gelir. Mikrobiyal saldırılara karşı bu hücrelerin bazıları fagositoz yaparak inflamatuvar yanıtı başlatırlar ve organizmanın ilk koruma hattını oluştururlar. Organizmada, bu inflamatuvar yanıta, kalıtımsal olarak aktarılan, patojen tanıyan reseptörlerin (PRR) uyarılması da katkı verir. PRR’ler hem mikrobiyal patojenle ilişkili moleküler kalıpları (PAMP) tanırlar, hem de doku hasarı ve nekrotik hücre ölümü gibi stres faktörleri altında kalan organizmanın kendisi tarafından salgılanan maddelere immun reaksiyon gösterirler. PRR’ler birçok alt tipe ayrılır, bunlar içerisinde en iyi tanımlananlar Toll Benzeri Reseptörlerdir (Toll Like Receptors, TLR). İnsanlarda 10 (TLR1–TLR10), farelerde ise 12 (TLR1–TLR9, TLR11–TLR13) farklı TLR tanımlanmıştır. TLR’ler hücre yüzeyine veya endozom, lizozom, endolizozom gibi hücre içi kompartımanlara lokalize olurlar. Bu moleküller makrofaj ve dendritik hücreler gibi immun sistem hücrelerinin yanında fibroblast ve epitel hücreleri gibi immun sistem dışındaki hücrelerde de eksprese edilebilir. TLR’ler kendileriyle homodimer şeklinde veya koreseptörleri ve aksesuar molekülleriyle heterodimer oluştururlar. Hücre yüzeyinde bulunan TLR’ler öncellikle lipid, lipoprotein, protein gibi mikrobiyal membran bileşenlerini tanırlar. Buna karşın hücre içindeki TLR’ler bakteri ve virüs orjinli nükleik asitleri algılarlar. Ayrıca vücudun kendi nükleik asitlerini tanıyıp otoimmun hastalıklara neden olabilirler.

TLR’ler organizmada hemen hemen bütün sistemlerde immun sistem hücreleri ile birlikte diğer bazı hücrelerde ekspresyon gösterirler. Son yıllarda yapılan çalışmalarla, kanser ve otoimmun hastalıkların patogenezinde TLR’lerin rolü olduğu gösterilmiştir. İlerleyen yıllarda bu reseptörlere karşı kullanılan agonist veya antogonistlerin belirtilen hastalıkların sağaltımında faydalı olabileceği düşünülmektedir.

Keywords

Doğal bağışıklık,patojen tanıyan reseptörler

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Mehmet Özbek
Mehmet Akif Ersoy Üniversitesi, Veteriner Fakültesi, Histoloji Embriyoloji Anabilim Dalı
Türkiye

Mustafa Hitit
Selçuk Üniversitesi, Veteriner Fakültesi, Genetik Anabilim Dalı
Türkiye

Emel Ergün
Ankara Üniversitesi, Veteriner Fakültesi, Histoloji Embriyoloji Anabilim Dalı
Türkiye

Feyzullah Beyaz
Erciyes Üniversitesi, Veteriner Fakültesi, Histoloji Embriyoloji Anabilim Dalı
Türkiye

Levent Ergün
Ankara Üniversitesi, Veteriner Fakültesi, Histoloji Embriyoloji Anabilim Dalı
Türkiye

Publication Date

December 25, 2017

Submission Date

August 21, 2017

Acceptance Date

November 27, 2017

Published in Issue

Year 2017 Volume: 5 Number: 2

DOI

https://doi.org/10.24998/maeusabed.335529

IZ

https://izlik.org/JA36CN25YC

Cite

RIS / Bibtex

APA

Özbek, M., Hitit, M., Ergün, E., Beyaz, F., & Ergün, L. (2017). Toll benzeri reseptörler. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 5(2), 180-192. https://doi.org/10.24998/maeusabed.335529

AMA

1.Özbek M, Hitit M, Ergün E, Beyaz F, Ergün L. Toll benzeri reseptörler. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017;5(2):180-192. doi:10.24998/maeusabed.335529

Chicago

Özbek, Mehmet, Mustafa Hitit, Emel Ergün, Feyzullah Beyaz, and Levent Ergün. 2017. “Toll Benzeri Reseptörler”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5 (2): 180-92. https://doi.org/10.24998/maeusabed.335529.

EndNote

Özbek M, Hitit M, Ergün E, Beyaz F, Ergün L (December 1, 2017) Toll benzeri reseptörler. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5 2 180–192.

IEEE

[1]M. Özbek, M. Hitit, E. Ergün, F. Beyaz, and L. Ergün, “Toll benzeri reseptörler”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 5, no. 2, pp. 180–192, Dec. 2017, doi: 10.24998/maeusabed.335529.

ISNAD

Özbek, Mehmet - Hitit, Mustafa - Ergün, Emel - Beyaz, Feyzullah - Ergün, Levent. “Toll Benzeri Reseptörler”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5/2 (December 1, 2017): 180-192. https://doi.org/10.24998/maeusabed.335529.

JAMA

1.Özbek M, Hitit M, Ergün E, Beyaz F, Ergün L. Toll benzeri reseptörler. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017;5:180–192.

MLA

Özbek, Mehmet, et al. “Toll Benzeri Reseptörler”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 5, no. 2, Dec. 2017, pp. 180-92, doi:10.24998/maeusabed.335529.

Vancouver

1.Mehmet Özbek, Mustafa Hitit, Emel Ergün, Feyzullah Beyaz, Levent Ergün. Toll benzeri reseptörler. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017 Dec. 1;5(2):180-92. doi:10.24998/maeusabed.335529

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