Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi

Cennet Sinem Çoban; Duygu Mutluay

doi:10.24998/maeusabed.352205

Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi

Abstract

Farelerde preimplantasyon embriyo gelişimi blastosistin uterus duvarına tutunması ile son bulur. Blastosist dönemi hem implantasyon hem de gebelik için kritik bir süreçtir. E 3.5 dönemindeki fare blastosistleri trofektoderm (TE) ve iç hücre kütlesi (ICM) olmak üzere iki hücre soyundan oluşur. Daha sonradan plasentayı meydana getirecek olan TE hücreleri annenin uterus ile bağlantı kurarken ICM hücreleri fetusu ve ekstra embriyonik dokuları meydana getirir. E3.5 blastosist döneminden sonra ICM hücreleri pluripotent epiblast (Epi) ve primitif endoderm (PrE) olmak üzere iki farklı embriyonik soya farklılaşır. Bu üç hücre soyunun (TE, PrE, Epi) başarılı bir şekilde oluşumu embriyo modellenmesi, implantasyon ve embriyonik gelişimin sürdürülebilmesi bakımından kritik bir önem taşır. Bu makalede fare embriyo gelişiminde erken soy belirlenmesinde rol oynayan hücresel ve moleküler mekanizmalar hakkında bilgiler derlenmiştir. Bu süreçlerin anlaşılması hem başarılı bir implantasyon ve fetal gelişimin sağlanması amacıyla kullanılan yardımcı üreme tekniklerinin, aynı zaman da erken düşükler ve gebelik patolojilerinin nedenlerinin ortaya konulması bakımından önemlidir.

Keywords

blastosist,fare,hücre farklılaşması,hücre soyu,preimplantasyon gelişimİ

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Cennet Sinem Çoban
Türkiye

Duygu Mutluay This is me
MEHMET AKİF ERSOY ÜNİVERSİTESİ
Türkiye

Publication Date

December 25, 2017

Submission Date

November 14, 2017

Acceptance Date

December 6, 2017

Published in Issue

Year 2017 Volume: 5 Number: 2

DOI

https://doi.org/10.24998/maeusabed.352205

IZ

https://izlik.org/JA92BF47BW

Cite

RIS / Bibtex

APA

Çoban, C. S., & Mutluay, D. (2017). Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 5(2), 219-227. https://doi.org/10.24998/maeusabed.352205

AMA

1.Çoban CS, Mutluay D. Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017;5(2):219-227. doi:10.24998/maeusabed.352205

Chicago

Çoban, Cennet Sinem, and Duygu Mutluay. 2017. “Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5 (2): 219-27. https://doi.org/10.24998/maeusabed.352205.

EndNote

Çoban CS, Mutluay D (December 1, 2017) Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5 2 219–227.

IEEE

[1]C. S. Çoban and D. Mutluay, “Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 5, no. 2, pp. 219–227, Dec. 2017, doi: 10.24998/maeusabed.352205.

ISNAD

Çoban, Cennet Sinem - Mutluay, Duygu. “Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 5/2 (December 1, 2017): 219-227. https://doi.org/10.24998/maeusabed.352205.

JAMA

1.Çoban CS, Mutluay D. Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017;5:219–227.

MLA

Çoban, Cennet Sinem, and Duygu Mutluay. “Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 5, no. 2, Dec. 2017, pp. 219-27, doi:10.24998/maeusabed.352205.

Vancouver

1.Cennet Sinem Çoban, Duygu Mutluay. Fare Blastosistlerinde Hücre Kaderinin Belirlenmesi. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2017 Dec. 1;5(2):219-27. doi:10.24998/maeusabed.352205