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Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri

Year 2018, Volume: 6 Issue: 2, 95 - 108, 30.12.2018
https://doi.org/10.24998/maeusabed.497432

Abstract

Fumonisinler başlıca Fusarium türü mantarlar tarafından üretilen özellikle mısır ve mısır bazlı ürünlerde sıklıkla bulunan bir grup mikotoksindir. Fumonisinler A, B, C ve P şeklinde 4 formda olmakla birlikte bunlar içerisinde toksikolojik açıdan en önemlisi fumonisin B'dir. Fumonisinler yapısal olarak sfingolipidlere önemli derecede benzerlik gösterirler. Sfingolipidler bütün ökaryotik hücrelerde özellikle de membranlarda bulunan, hücre membran biyolojisinde önemli rol oynayan ve hücre işlevini düzenleyen birçok biyoaktif metabolitleri içeren geniş bir lipid ailesidir. Bunlar hücre büyümesinin regülasyonunda, hücreler arası iletişimde, apoptozisde, hücre farklılaşmasında ve sitosikletal proteinler, immunglobinler ve bazı bakteriyel toksinler için hücre yüzeyi
reseptörü olarak bilinmektedir. Fumonisinler toksik etkilerini, sfinganin, sfingozin ve diğer sfingoid bazların N-asilasyonunu katalize eden seramid sentaz enzimini (Sfinganin N-asiltransferaz) inhibisyonu sonucu sfingolipid metabolizmasını bozarak gösterirler. Fumonisinler hayvan türlerine özgü farklı toksik etkiler göstermekle birlikte benzer etkiler de gösterebilirler. Atlarda lökoensefalomalazi, domuzlarda pulmoner ödem ve nefrotoksisite, rat, fare ve tavşanlarda karaciğer toksisitesi ve nefrotoksisiteye yol açtığı bilinmektedir. İnsanlarda Güney Afrika’nın bazı bölgelerinde Fusarium türleri ile kontamine mısır ve mısır ürünlerini yüksek oranda tüketen yerel halkta özofagus kanseri görülme sıklığında artış tespit edilmiştir. Fumonisinlerin insanlardaki toksik etkileri özellikle karsinojenik etkileri tam olarak kanıtlanmasa da toplum sağlığı açısından bu konuda daha detaylı çalışmaların yapılması gerekmektedir. Fumonisinler insan ve hayvan sağlığı açısından günümüzde potansiyel bir tehlike olarak görülmektedir. Bununla birlikte fumonisinler ile kontaminasyon doğada kaçınılmaz görülmemektedir. Dolasıyla hayvan yemlerinde ve insan tüketimine sunulan gıdalarda otoritelerce belirlenen güvenli limitlerin sağlanması insan ve hayvan sağlığı açısından önem arz etmektedir.

References

  • 1. Alberts JF, Gelderblom WCA, Thiel PG, ve ark. 1990. Effects of temperature and incubation period on production of fumonisin B1 by Fusarium moniliforme. Applied Environmental Microbiology. 56: 1729–1733. 2. Albonico M, Schütz LF, Caloni F, ve ark. 2016. Toxicological effects of fumonisin B1 alone and in combination with other fusariotoxins on bovine granulosa cells. Toxicon. 118: 47-53. 3. Alizadeh AM, Mohammadghasemi F, Zendehdel K, ve ark. 2015. Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1. Iranian Journal of Basic Medical Sciences. 18: 8-13. 4. Becker BA, Pace L, Rottinghaus GE, ve ark. 1995. Effects of feeding fumonisin B1 in lactating sows and their suckling pigs. American Journal of Veterinary Research. 56(9): 1253-1258.5. Bennett JW, Klich M. 2003. Mycotoxins. American Society for Microbiology. 16(3): 497–516.6. Blackwell BA, Edwards OE, Fruchier A, ve ark. 1996. NMR structural studies of fumonisin B1 and related compounds from Fusarium moniliforme. Advances in Experimental Medicine and Biology. 392: 75-91.7. Chuturgoon AA, Phulukdaree A, Moodley D. 2014. Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. Toxicology Letters. 227: 50–55. 8. Didwania N, Joshi M. 2013. Mycotoxins: A critical review on occurrence and significance. International Journal of Pharmacy and Pharmaceutical Sciences. 5(3): 1014-1019. 9. Edrington TS, Kamps-Holtzapple CA, Harvey RB, ve ark. 1995. Acute hepatic and renal toxicity in lambs dosed with fumonisin-containing culture material. Journal of Animal Science. 73(2): 508-515.10. Osweiler GD, Kehrli ME, Stabel JR, ve ark. 1993. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves. Journal of Animal Science. 71(2): 459-466.11. Escrivá L, Font G, Manyes L. 2015. In vivo toxicity studies of fusarium mycotoxins in the last decade: a review. Food and Chemical Toxicology. 78: 185–206. 12. FDA, 2001. Guidance for industry fumonisin levels in human foods and animal feeds. https://www.fda.gov/food/guidanceregulation/guidancedocumentsregulatoryinformation/ucm109231.htm. (Erişim tarihi: 03.05.2017)13. Gallo A, Giuberti G, Frisvad JC, ve ark. 2015. Review on mycotoxin issues in ruminants: occurrence in forages, effects of mycotoxin ingestion on health status and animal performance and practical strategies to counteract their negative effects. Toxins. 7: 3057-3111.14. Galvano F, Campisi A, Russo A, ve ark. 2002. DNA damage in astrocytes exposed to fumonisin B1. Neurochemical Research. 27: 345–351. 15. Gault CR, Obeid LM, Hannun YA. 2010. An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1–23.16. Gazzotti T, Zironi E, Lugoboni B, ve ark. 2011. Analysis of fumonisins B1, B2 and their hydrolysed metabolites in pig liver by LC–MS/MS. Food Chemistry. 125: 1379–1384.17. Gbore FA, Egbunike GN. 2008. Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B1. Animal Reproduction Science. 105: 392–397. 18. Gelderblom WCA, Jaskiewicz K, Marasas WFO, ve ark. 1988. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology. 54: 1806-1811. 19. Gelineau-van Waes J, Starr L, Maddox J, ve ark. 2005. Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. Birth Defects Research Part A: Clinical and Molecular Teratology. 73: 487–497.20. Guzman RE, Casteel SW, Rottinghaus GE, ve ark. 1997. Chronic consumption of fumonisins derived from Fusarium moniliforme culture material: clinical and pathologic effects in swine. Journal of Veterinary Diagnostic Investigation. 9(2): 216-218.21. Hannun YA. 1994. The sphingomyelin cycle and the second messenger function of ceramide. Journal of Biological Chemistry. 269 (5): 3125-3128. 22. Haschek WM, Motelin G, Ness DK, ve ark. 1992. Characterization of fumonisin toxicity in orally and intravenously dosed swine. Mycopathologia. 117(1-2): 83-96.23. Kellerman TS, Marasas, WFO, Thiel PG, ve ark. 1990. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort Journal of Veterinary Research. 57: 269-275. 24. Kriek NPJ, Kellerman TS, Marasas WFO. 1981. A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort Journal of Veterinary Research. 48: 129-131.25. Lahiri S, Futerman AH (2007): The metabolism and function of sphingolipids and glycosphingolipids. Cellular and Molecular Life Sciences. 64(17): 2270-2284.26. Marasas WFO, Wehner FC, Van Rensburg SJ, ve ark. 1980. Mycoflora of corn produced in human esophageal cancer areas in Transkei, Southern Africa. Phytopathology. 71: 792-796.27. Marin S, Ramos AJ, Cano-Sancho G, ve ark. 2013. Mycotoxins: Occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology. 60: 218–237. 28. Marliére CA, Pimenta RCJ, Cunha AC. 2009. Fumonisin as a risk factor to esophageal cancer: a review. Applied Cancer Research. 29(3): 102-105. 29. Mathur S, Constable PD, Eppley RM, ve ark. 2001. Fumonisin B1 is hepatotoxic and nephrotoxic in milk-fed calves. Toxicological Sciences. 60(2): 385-396.30. Mehrotra RS, Aneja KR. 1990. An Introduction to Mycology, New Age International, New Delhi, p:1-65.31. Merrill AH, Schmelz EM, Dillehay DL, ve ark. 1997. Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicology and Applied Pharmacology. 142(1): 208-25.32. Merrill AH, Schmelz EM, Wang E, ve ark. 1995. Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. The Journal of Nutrition. 125(6): 1677S-1682S.33. Motelin GK, Haschek WM, Ness DK, ve ark 1994. Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins. Mycopathologia. 126(1): 27-40.34. Norred WP, Voss KA. 1994. Toxicity and role of fumonisins in animal diseases and human esophageal cancer. Journal of Food Protection. 57(6): 522-527. 35. Norred WP, Voss KA, Riley RT, ve ark. 1998. Mycotoxins and health hazards: toxicological aspects and mechanism of action of fumonisins. The Journal of Toxicological Sciences. 23(2): 160-164.36. Okazaki T, Bielawska A, Bell RM, ve ark. 1990. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. The Journal of Biological Chemistry. 265: 15823-15831.37. Orsi RB, Dilkin P, Xavier JG, ve ark. 2009. Acute toxicity of a single gavage dose of fumonisin B1 in rabbits. Chemico-Biological Interactions. 179: 351–355. 38. Osweiler GD, Kehrli ME, Stabel JR, ve ark. 1993. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves. Journal of Animal Science. 71(2): 459-66.39. Plattner RD, Weisleder D, Shackelford DD, ve ark. 1992 A new fumonisin from solid cultures of fusarium moniliforme. Mycopathologia. 117 (1): 23-28. 40. Ross PF, Ledet AE, Owens DL, ve ark. 1993. Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins. Journal of Veterinary Diagnostic Investigation. 5(1): 69-74.41. Sadler TW, Merrill AH, Stevens VL, ve ark. 2002. Prevention of fumonisin B1-induced neural tube defects by folic acid. Teratology. 66(4): 169-176.42. Scott PM. 1993. Fumonisins. International Journal of Food Microbiology. 18(4): 257-270.43. Scott PM. 2012. Recent research on fumonisins: a review. Food Additives and Contaminants. 29(2): 242–248. 44. Scott PM, Delgado T, Prelusky DB, ve ark. 1994. Determination of fumonisins in milk. Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 29(5): 989-998.45. Smith JS, Thakur RA 1996. Occurrence and fate of fumonisins in beef. Advances in Experimental Medicine and Biology. 392: 39-55.46. Stockmann-Juvala H, Savolainen K. 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & Experimental Toxicology. 27: 799–809.47. Stoeva SD, Gundasheva D, Zarkov I, ve ark. 2012. Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. Experimental and Toxicologic Pathology. 64: 733–741. 48. Sydenham EW, Thiel PG, Marasas WFO, ve ark. 1990. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, Southern Africa. The Journal of Agricultural and Food Chemistry. 38: 1900–1903.49. The EFSA Journal. 2005. Opinion of the Scientific Panel on contaminants in food chain on arequest from the commission related to fumonisins as undesirable substances in animal feed. The EFSA Journal. 235: 1-32. 50. Todorova K, Georgieva A, Dimitrov P, ve ark. 2015. Cytotoxicity and immunolocalization of fumonisin B1’in dec99 and balb/c 3t3 cell lines. Trakia Journal of Sciences. 13(2): 74-80. 51. Türk Gıda Kodeksi Bulaşanlar Yönetmeliği. 2011. Gıda, Tarım ve Hayvancılık Bakanlığı Mevzuatı, Resmi Gazete Tarihi: 29.12.2011-28157 (3.mükerrer). 52. Vendruscolo CP, Frias NC, de Carvalho CB, ve ark. 2016. Leukoencephalomalacia outbreak in horses due to consumption of contaminated hay. Journal of Veterinary Internal Medicine. 30(6): 1879–1881.53. Voss KA, Riley RT. 2013. Fumonisin toxicity and mechanism of action: overview and current perspectives. Food Safety. 1(1): 49-69.54. Voss KA, Smith GW, Haschek WM. 2007. Fumonisins: Toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology. 137: 299–325.55. Vudathala DK, Prelusky DB, Ayroud M, ve ark. 1994. Pharmacokinetic fate and pathological effects of 14C-fumonisin B1 in laying hens. Natural Toxins. 2: 81–88. 56. Wang E, Norred WP, Bacon CP, ve ark. 1991. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry. 266: 14486-14490.57. Wang X, Wu Q, Wan D, ve ark. 2016. Fumonisins: oxidative stress mediated toxicity and metabolism in vivo and in vitro. Archives of Toxicology. 90: 81–101. 58. Waśkiewicz A, Beszterda M, Goliński P. 2012. Occurrence of fumonisins in food - an interdisciplinary approach to the problem. Food Control. 26: 491-499.59. WHO. 2000. Fumonisin B1 (Environmental health criteria 219). International Programme on Chemical Safety. Geneva, 1-153.60. Yazar S, Omurtag GZ. 2008. Fumonisins, trichothecenes and zearalenone in cereals. International Journal of Molecular Sciences. 9: 2062-2090.61. Zomborszky-Kovács M, Vetési F, Kovács F, ve ark. 2000. Preliminary communication: Examination of the harmful effect to fetuses of fumonisin B1 in pregnant sows. Teratogenesis, Carcinogenesis and Mutagenesis. 20: 293–299.

Fumonisins: Adverse Effects on Human and Animal Health

Year 2018, Volume: 6 Issue: 2, 95 - 108, 30.12.2018
https://doi.org/10.24998/maeusabed.497432

Abstract

Fumonisins are a group of mycotoxins that are commonly found in Fusarium-type fungi, especially in corn and cornbased products. Fumonisins A, B, C and P in the form of 4 form, although the most toxicologically important fumonisin B (B1, B2 and B3) 'is. Fumonisins are structurally similar to sphingolipids. Sphingolipids are a wide family of lipids that contain many bioactive metabolites in all eukaryotic cells, especially membranes, which play an important role in cell membrane biology and regulate cell function. They are known to act in cell growth regulation, intercellular communication, apoptosis, cell differentiation, and as cell surface receptors for cytoskeletal proteins, immunoglobulins and some bacterial toxins. Fumonisins show toxic effects by disrupting sphingolipid metabolism as a result of inhibition of ceramide synthase enzyme (Sfinganine N-acyltransferase) which catalyzes N-acylation of sphinganine, sphingosine and other sphingoid bases. Fumonisins show different toxic effects specific to animal species, but may also have similar effects. It is known that leukoencephalomalacia in horses, pulmonary edema and nephrotoxicity in pigs, liver toxicity and nephrotoxicity in rats, mice and rabbits. An increase in the prevalence of esophageal cancer has been found in the local population, who consume high levels of corn and corn products contaminated with Fusarium species in humans in some parts of South Africa. Although the toxic effects of fumonisins in human beings are not fully proved, especially in terms of public health, more detailed studies should be done about this issue. Fumonisins are considered to be a potential threat to human and animal health. However, contamination with fumonisins is not inevitable in nature. Therefore, it is important for human and animal health to provide safe limits determined by the authorities in animal feeds and foods that are offered to human consumption.

References

  • 1. Alberts JF, Gelderblom WCA, Thiel PG, ve ark. 1990. Effects of temperature and incubation period on production of fumonisin B1 by Fusarium moniliforme. Applied Environmental Microbiology. 56: 1729–1733. 2. Albonico M, Schütz LF, Caloni F, ve ark. 2016. Toxicological effects of fumonisin B1 alone and in combination with other fusariotoxins on bovine granulosa cells. Toxicon. 118: 47-53. 3. Alizadeh AM, Mohammadghasemi F, Zendehdel K, ve ark. 2015. Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1. Iranian Journal of Basic Medical Sciences. 18: 8-13. 4. Becker BA, Pace L, Rottinghaus GE, ve ark. 1995. Effects of feeding fumonisin B1 in lactating sows and their suckling pigs. American Journal of Veterinary Research. 56(9): 1253-1258.5. Bennett JW, Klich M. 2003. Mycotoxins. American Society for Microbiology. 16(3): 497–516.6. Blackwell BA, Edwards OE, Fruchier A, ve ark. 1996. NMR structural studies of fumonisin B1 and related compounds from Fusarium moniliforme. Advances in Experimental Medicine and Biology. 392: 75-91.7. Chuturgoon AA, Phulukdaree A, Moodley D. 2014. Fumonisin B1 modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. Toxicology Letters. 227: 50–55. 8. Didwania N, Joshi M. 2013. Mycotoxins: A critical review on occurrence and significance. International Journal of Pharmacy and Pharmaceutical Sciences. 5(3): 1014-1019. 9. Edrington TS, Kamps-Holtzapple CA, Harvey RB, ve ark. 1995. Acute hepatic and renal toxicity in lambs dosed with fumonisin-containing culture material. Journal of Animal Science. 73(2): 508-515.10. Osweiler GD, Kehrli ME, Stabel JR, ve ark. 1993. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves. Journal of Animal Science. 71(2): 459-466.11. Escrivá L, Font G, Manyes L. 2015. In vivo toxicity studies of fusarium mycotoxins in the last decade: a review. Food and Chemical Toxicology. 78: 185–206. 12. FDA, 2001. Guidance for industry fumonisin levels in human foods and animal feeds. https://www.fda.gov/food/guidanceregulation/guidancedocumentsregulatoryinformation/ucm109231.htm. (Erişim tarihi: 03.05.2017)13. Gallo A, Giuberti G, Frisvad JC, ve ark. 2015. Review on mycotoxin issues in ruminants: occurrence in forages, effects of mycotoxin ingestion on health status and animal performance and practical strategies to counteract their negative effects. Toxins. 7: 3057-3111.14. Galvano F, Campisi A, Russo A, ve ark. 2002. DNA damage in astrocytes exposed to fumonisin B1. Neurochemical Research. 27: 345–351. 15. Gault CR, Obeid LM, Hannun YA. 2010. An overview of sphingolipid metabolism: from synthesis to breakdown. Advances in Experimental Medicine and Biology. 688: 1–23.16. Gazzotti T, Zironi E, Lugoboni B, ve ark. 2011. Analysis of fumonisins B1, B2 and their hydrolysed metabolites in pig liver by LC–MS/MS. Food Chemistry. 125: 1379–1384.17. Gbore FA, Egbunike GN. 2008. Testicular and epididymal sperm reserves and sperm production of pubertal boars fed dietary fumonisin B1. Animal Reproduction Science. 105: 392–397. 18. Gelderblom WCA, Jaskiewicz K, Marasas WFO, ve ark. 1988. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology. 54: 1806-1811. 19. Gelineau-van Waes J, Starr L, Maddox J, ve ark. 2005. Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. Birth Defects Research Part A: Clinical and Molecular Teratology. 73: 487–497.20. Guzman RE, Casteel SW, Rottinghaus GE, ve ark. 1997. Chronic consumption of fumonisins derived from Fusarium moniliforme culture material: clinical and pathologic effects in swine. Journal of Veterinary Diagnostic Investigation. 9(2): 216-218.21. Hannun YA. 1994. The sphingomyelin cycle and the second messenger function of ceramide. Journal of Biological Chemistry. 269 (5): 3125-3128. 22. Haschek WM, Motelin G, Ness DK, ve ark. 1992. Characterization of fumonisin toxicity in orally and intravenously dosed swine. Mycopathologia. 117(1-2): 83-96.23. Kellerman TS, Marasas, WFO, Thiel PG, ve ark. 1990. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort Journal of Veterinary Research. 57: 269-275. 24. Kriek NPJ, Kellerman TS, Marasas WFO. 1981. A comparative study of the toxicity of Fusarium verticillioides (= F. moniliforme) to horses, primates, pigs, sheep and rats. Onderstepoort Journal of Veterinary Research. 48: 129-131.25. Lahiri S, Futerman AH (2007): The metabolism and function of sphingolipids and glycosphingolipids. Cellular and Molecular Life Sciences. 64(17): 2270-2284.26. Marasas WFO, Wehner FC, Van Rensburg SJ, ve ark. 1980. Mycoflora of corn produced in human esophageal cancer areas in Transkei, Southern Africa. Phytopathology. 71: 792-796.27. Marin S, Ramos AJ, Cano-Sancho G, ve ark. 2013. Mycotoxins: Occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology. 60: 218–237. 28. Marliére CA, Pimenta RCJ, Cunha AC. 2009. Fumonisin as a risk factor to esophageal cancer: a review. Applied Cancer Research. 29(3): 102-105. 29. Mathur S, Constable PD, Eppley RM, ve ark. 2001. Fumonisin B1 is hepatotoxic and nephrotoxic in milk-fed calves. Toxicological Sciences. 60(2): 385-396.30. Mehrotra RS, Aneja KR. 1990. An Introduction to Mycology, New Age International, New Delhi, p:1-65.31. Merrill AH, Schmelz EM, Dillehay DL, ve ark. 1997. Sphingolipids-the enigmatic lipid class: biochemistry, physiology, and pathophysiology. Toxicology and Applied Pharmacology. 142(1): 208-25.32. Merrill AH, Schmelz EM, Wang E, ve ark. 1995. Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. The Journal of Nutrition. 125(6): 1677S-1682S.33. Motelin GK, Haschek WM, Ness DK, ve ark 1994. Temporal and dose-response features in swine fed corn screenings contaminated with fumonisin mycotoxins. Mycopathologia. 126(1): 27-40.34. Norred WP, Voss KA. 1994. Toxicity and role of fumonisins in animal diseases and human esophageal cancer. Journal of Food Protection. 57(6): 522-527. 35. Norred WP, Voss KA, Riley RT, ve ark. 1998. Mycotoxins and health hazards: toxicological aspects and mechanism of action of fumonisins. The Journal of Toxicological Sciences. 23(2): 160-164.36. Okazaki T, Bielawska A, Bell RM, ve ark. 1990. Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. The Journal of Biological Chemistry. 265: 15823-15831.37. Orsi RB, Dilkin P, Xavier JG, ve ark. 2009. Acute toxicity of a single gavage dose of fumonisin B1 in rabbits. Chemico-Biological Interactions. 179: 351–355. 38. Osweiler GD, Kehrli ME, Stabel JR, ve ark. 1993. Effects of fumonisin-contaminated corn screenings on growth and health of feeder calves. Journal of Animal Science. 71(2): 459-66.39. Plattner RD, Weisleder D, Shackelford DD, ve ark. 1992 A new fumonisin from solid cultures of fusarium moniliforme. Mycopathologia. 117 (1): 23-28. 40. Ross PF, Ledet AE, Owens DL, ve ark. 1993. Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins. Journal of Veterinary Diagnostic Investigation. 5(1): 69-74.41. Sadler TW, Merrill AH, Stevens VL, ve ark. 2002. Prevention of fumonisin B1-induced neural tube defects by folic acid. Teratology. 66(4): 169-176.42. Scott PM. 1993. Fumonisins. International Journal of Food Microbiology. 18(4): 257-270.43. Scott PM. 2012. Recent research on fumonisins: a review. Food Additives and Contaminants. 29(2): 242–248. 44. Scott PM, Delgado T, Prelusky DB, ve ark. 1994. Determination of fumonisins in milk. Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 29(5): 989-998.45. Smith JS, Thakur RA 1996. Occurrence and fate of fumonisins in beef. Advances in Experimental Medicine and Biology. 392: 39-55.46. Stockmann-Juvala H, Savolainen K. 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Human & Experimental Toxicology. 27: 799–809.47. Stoeva SD, Gundasheva D, Zarkov I, ve ark. 2012. Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. Experimental and Toxicologic Pathology. 64: 733–741. 48. Sydenham EW, Thiel PG, Marasas WFO, ve ark. 1990. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, Southern Africa. The Journal of Agricultural and Food Chemistry. 38: 1900–1903.49. The EFSA Journal. 2005. Opinion of the Scientific Panel on contaminants in food chain on arequest from the commission related to fumonisins as undesirable substances in animal feed. The EFSA Journal. 235: 1-32. 50. Todorova K, Georgieva A, Dimitrov P, ve ark. 2015. Cytotoxicity and immunolocalization of fumonisin B1’in dec99 and balb/c 3t3 cell lines. Trakia Journal of Sciences. 13(2): 74-80. 51. Türk Gıda Kodeksi Bulaşanlar Yönetmeliği. 2011. Gıda, Tarım ve Hayvancılık Bakanlığı Mevzuatı, Resmi Gazete Tarihi: 29.12.2011-28157 (3.mükerrer). 52. Vendruscolo CP, Frias NC, de Carvalho CB, ve ark. 2016. Leukoencephalomalacia outbreak in horses due to consumption of contaminated hay. Journal of Veterinary Internal Medicine. 30(6): 1879–1881.53. Voss KA, Riley RT. 2013. Fumonisin toxicity and mechanism of action: overview and current perspectives. Food Safety. 1(1): 49-69.54. Voss KA, Smith GW, Haschek WM. 2007. Fumonisins: Toxicokinetics, mechanism of action and toxicity. Animal Feed Science and Technology. 137: 299–325.55. Vudathala DK, Prelusky DB, Ayroud M, ve ark. 1994. Pharmacokinetic fate and pathological effects of 14C-fumonisin B1 in laying hens. Natural Toxins. 2: 81–88. 56. Wang E, Norred WP, Bacon CP, ve ark. 1991. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry. 266: 14486-14490.57. Wang X, Wu Q, Wan D, ve ark. 2016. Fumonisins: oxidative stress mediated toxicity and metabolism in vivo and in vitro. Archives of Toxicology. 90: 81–101. 58. Waśkiewicz A, Beszterda M, Goliński P. 2012. Occurrence of fumonisins in food - an interdisciplinary approach to the problem. Food Control. 26: 491-499.59. WHO. 2000. Fumonisin B1 (Environmental health criteria 219). International Programme on Chemical Safety. Geneva, 1-153.60. Yazar S, Omurtag GZ. 2008. Fumonisins, trichothecenes and zearalenone in cereals. International Journal of Molecular Sciences. 9: 2062-2090.61. Zomborszky-Kovács M, Vetési F, Kovács F, ve ark. 2000. Preliminary communication: Examination of the harmful effect to fetuses of fumonisin B1 in pregnant sows. Teratogenesis, Carcinogenesis and Mutagenesis. 20: 293–299.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Rıza Yalçın This is me

Asım Kart

Publication Date December 30, 2018
Submission Date December 14, 2018
Published in Issue Year 2018 Volume: 6 Issue: 2

Cite

APA Yalçın, R., & Kart, A. (2018). Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 6(2), 95-108. https://doi.org/10.24998/maeusabed.497432
AMA Yalçın R, Kart A. Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri. Mehmet Akif Ersoy University Journal of Health Sciences Institute. December 2018;6(2):95-108. doi:10.24998/maeusabed.497432
Chicago Yalçın, Rıza, and Asım Kart. “Fumonisinler: İnsan Ve Hayvan Sağlığı Üzerine Olumsuz Etkileri”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 6, no. 2 (December 2018): 95-108. https://doi.org/10.24998/maeusabed.497432.
EndNote Yalçın R, Kart A (December 1, 2018) Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri. Mehmet Akif Ersoy University Journal of Health Sciences Institute 6 2 95–108.
IEEE R. Yalçın and A. Kart, “Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 6, no. 2, pp. 95–108, 2018, doi: 10.24998/maeusabed.497432.
ISNAD Yalçın, Rıza - Kart, Asım. “Fumonisinler: İnsan Ve Hayvan Sağlığı Üzerine Olumsuz Etkileri”. Mehmet Akif Ersoy University Journal of Health Sciences Institute 6/2 (December 2018), 95-108. https://doi.org/10.24998/maeusabed.497432.
JAMA Yalçın R, Kart A. Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2018;6:95–108.
MLA Yalçın, Rıza and Asım Kart. “Fumonisinler: İnsan Ve Hayvan Sağlığı Üzerine Olumsuz Etkileri”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, vol. 6, no. 2, 2018, pp. 95-108, doi:10.24998/maeusabed.497432.
Vancouver Yalçın R, Kart A. Fumonisinler: İnsan ve Hayvan Sağlığı Üzerine Olumsuz Etkileri. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2018;6(2):95-108.