Sepsisli Neonatal Buzağılarda Bazı Hematolojik ve Biyokimyasal Parametrelerin Araştırılması

Year 2019, Volume: 7 Issue: 2, 55 - 67, 30.12.2019

Yasemin Beydilli , Halil İbrahim Gökce

https://doi.org/10.24998/maeusabed.617316

Cited By: 4

Abstract

Öz: Çalışmanın amacı sepsisli
neonatal buzağılarda hematolojik ve biyokimyasal değişimlerin araştırılmasıdır.
Çalışmada, 20 adet sepsisli ve klinik olarak sağlıklı 10 adet neonatal buzağı
kullanıldı. Bütün buzağıların rutin klinik muayenesi yapıldı ve monitörize
edilerek sistolik kan basıncı (SKB), diyastolik kan basıncı (DKB) ve ortalama
arteriyel kan basıncı (MAP) belirlendi. Ayrıca tüm hayvanların pulse oksimetre
ile oksijen satürasyonları (SpO₂) ölçüldü. Çalışmada yer alan tüm
buzağıların hematolojik ve biyokimyasal analizleri yapıldı. Çalışmada sepsisli buzağıların
vücut ısısı (p<0.001) ve SpO₂ (p<0.01) değerleri düşük,
solunum sayılarının (p<0.01) ise kontrol grubuna göre yüksek olduğu
belirlendi. Hematolojik analizlerde sepsisli buzağıların total lökosit (WBC,
p<0.001), monosit (MID, p<0.001), granülosit (GRA, p<0.01), ortalama
korpuskuler volüm (MCV, p<0.01), ortalama korpuskuler hemoglobin (MCH,
p<0.001) ve ortalama korpuskuler hemoglobin konsantrasyonu (MCHC, p<0.01)
düzeyleri kontrol grubu değerlerine göre yüksek bulundu. Çalışmada yapılan
biyokimyasal analizlerde ise sepsisli buzağıların total bilirubin (T.BİL,
p<0.01), direkt bilirubin (D.BİL, p<0.001), üre (ÜRE, p<0.001),
kreatinin (KREA, p<0.001), aspartat aminotrasferaz (AST, p<0.01) ve
laktat dehidrojenaz, p<0.001) değerlerinde kontrol grubuna göre anlamlı
artışlar saptanırken total protein (TP, p<0.01), albümin (ALB, p<0.001)
ve immunoglobulin (Ig, p<0.001) düzeylerinde ise önemli düzeyde düşüşler
belirlendi. Yatar pozisyonda olan sepsisli (şiddetli) grupta ayakta olan (orta
derecede) sepsisli buzağılara göre daha çok sayıda buzağıda hematolojik ve
biyokimyasal parametrelerde değişimler belirlendi. Elde edilen TP ve Ig
sonuçları sepsisli buzağılarda yetersiz kolostrum alındığını ve pasif immun
transfer yetmezliğinin geliştiğini göstermektedir. Sonuç olarak sepsis neonatal
buzağılarda önemli hematolojik ve biyokimyasal değişimlere neden olmakta ve kalp,
karaciğer ve böbrekler gibi organların fonksiyonlarını negatif yönde etkilemektedir.
Elde edilen bu sonuçların sepsisli buzağıların tanısı, tedavisinin
yönlendirilmesi ve prognozunun belirlenmesinde yararlı olacağı kanısındayız.

Anahtar Kelimeler: Biyokimya,
Buzağı, Hematoloji, Monitörizasyon, Sepsis.

Keywords

Biyokimya, Buzağı, Hematoloji, Monitörizasyon

Project Number

0467-YL-17

References

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