The Prognostic İmpact of CD163 Expression in Childhood Hodgkin Lypmhomas

Year 2022, , 7 - 10, 30.04.2022

Özben Yalçın , Emine Türkkan , Damla Karabıyık Altıok

https://doi.org/10.35514/mtd.2022.60

Abstract

Aim: The aim of this studay is to examine the relationship betwen CD163 expression and prognosis in pediatrik Hodgkin lymphoma cases.
Material-methods: In this study retrospectively; twenty-one pediatric patients were included who were treated and followed-up with the diagnosis of Hodgkin Lymphoma (HL) in the Pediatric Oncology and Hematology Clinics of Prof. Dr. Cemil Taşcıoğlu City Hospital, between January 2014 and December 2020. CD163 immunohistochemistry was applied to the initial diagnostic biopsies of the cases.
Results: The ages of the cases ranged from 6 to 17, with 4.8% (n=1) Stage 1, 28.6% (n=6) Stage 2, 33.3% (n=7) Stage 3, 33.3% (n=7) were diagnosed as Stage 4. B symptoms were present in 42.9% (n=9) of the cases, progression in 15% (n=3), and spleen involvement in 38% (n=8). Histological subtype distributions; 4.8% (n=1) lymphocyte-poor type, 33.3% (n=7) mixed cellular type, 4.8% (n=1) nodular lymphocyte predominant HL, 57.1% (n=12) nodular sclerosing type. When CD 163 expression values were examined, 38.1% (n=8) of the cases were below 5%, 33.3% (n=7) were between 5-25%, 28.6% (n=7) were 6) It is seen that it is >25%. According to CD163 expression groups, there was no statistically significant difference in terms of gender, age, stage, presence of B symptoms, progression status, histological subtypes and spleen involvement (p>0.05).
Conclusion: More extensive studies are required to understand the prognostic significance of CD163 expression in pediatric HL cases.

Keywords

Childhood Hodgkin lymphoma, CD163, tumor-associated macrophage

Çocukluk Çağı Hodgkin Lenfomalarında CD163 Ekspresyonunun Prognostik Önemi

Abstract

ÖZ
Amaç: Bu çalışmanın amacı, pediatrik Hodgkin lenfoma olgularında CD163 ekspresyonunun prognozla ilişkisini incelemektir.
Materyal-metod: Bu çalışmaya retrospektif olarak; Ocak 2014- Aralık 2020 tarihleri arasında Sağlık Bilimleri Üniversitesi Prof. Dr. Cemil Taşcıoğlu Şehir Hastanesi Pediatrik Onkoloji ve Hematoloji Klinikleri’nde Hodgkin Lenfoma (HL) tanısı ile tedavi ve takipleri yapılan 0-18 yaş aralığındaki, 21 pediatrik hasta dahil edildi. Olguların ilk tanı biyopsilerine CD163 immünhistokimyası uygulandı. CD163 ekspresyonlarına göre ; <%5, %5-25, >%25 olmak üzere 3 gruba ayrıldı.
Bulgular: Olguların yaşları 6 ile 17 arasında değişmekte olup %4,8’i (n=1) Evre 1, %28,6’sı (n=6) Evre 2, %33,3’ü (n=7) Evre 3, %33,3’ü (n=7) Evre 4 olarak tanı almıştır. Olguların %42,9’unda (n=9) B semptomu, %15’inde (n=3) progresyon, %38’inde (n=8) dalak tutulumu mevcuttur. Histolojik subtip dağılımları; %4,8 (n=1) lenfositten fakir tip, %33,3 (n=7) mikst selüler tip, %4,8 (n=1) nodüler lenfosit predominant HL, %57,1 (n=12) nodüler sklerozan tip şeklindedir. CD 163 ekspresyon değerleri incelendiğinde, olguların %38,1’inin (n=8) %5’in altında, %33,3’ünün (n=7) %5-25 aralığında, %28,6’sının (n=6) >%25 olduğu görülmektedir. CD163 ekspresyon gruplarına göre olguların cinsiyetleri, yaşları evreleri, B semptomu varlığı, progresyon durumu, histolojik subttipler ve dalak tutulumu açısından istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05).
Sonuç: CD163 ekspresyonun pediatrik HL olgularında prognostik öneminin anlaşılması için daha kapsamlı araştırmalar gerekmektedir.

Keywords

pediatrik Hodgkin lenfoma, CD163, tümör ilişkili makrofaj

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