Research Article
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Is vitamin D deficiency frequently in patients with cirrhosis?

Year 2023, , 83 - 87, 31.12.2023
https://doi.org/10.35514/mtd.2024.98

Abstract

Aim: In this study, it was aimed to compare the frequency of vitamin D deficiency in compensated and decompensated cirrhotic patients with the control group.
Materials and Methods: Eighty patients and eighty control groups which have liver cirrhosis are included in this study. The diagnosis of cirrhosis are made by clinical, laboratory and imaging methods. Ascites, variceal bleeding, and elevated bilirubin were accepted as signs of decompensation.
Results: 46 of 80 cirrhotic patients are male (57.5%), the average age of the patient group is 54.40 ± 11.77 and the age distribution is 18-75. The control group consisted of 44 males (55%), average age of the control group is 53.85 ± 9.59, and age distribution is 18-75.
In patients with decompensated cirrhosis, the frequency of low vitamin D levels below 10 ng/ml was found to be statistically significantly more frequent compared to patients with compensated cirrhosis and the control group (p<0.05), while a higher vitamin D level above 30 ng/ml in decompensated cirrhosis compared to compensated cirrhosis and control group. significantly lower frequency (p<0.05).
There was no correlation between MELD score, Child score and vitamin D level in cirrhotic patients.
Conclusion: No correlation was found between Child stage, MELD score, and vitamin D levels. Vitamin D deficiency requiring replacement is more common in decompensated cirrhotic patients compared to compensated cirrhosis and control group.

References

  • 1. Hill A, Starchl C, Dresen E, Stoppe C, Amrein K. An update of the effects of vitamins D and C in critical illness. Front Med (Lausanne). 2023;9:1083760. doi: 10.3389/fmed.2022.1083760. PMID: 36726354; PMCID: PMC9885715.
  • 2. Delrue C, Speeckaert R, Delanghe JR, Speeckaert MM. Vitamin D Deficiency: An Underestimated Factor in Sepsis? Int J Mol Sci. 2023;24(3):2924. doi: 10.3390/ijms24032924.
  • 3. Moctezuma-Velazquez, C, Garcia-Juárez I, Soto-Solis R, Hernandez-Cortes J, and Torre A. Nutritional assessment and treatment of patients with liver cirrhosis, Nutrition. 2013;29:1279-85.
  • 4. Yoshiji H, Nagoshi S, Akahane T, et al. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021;56(7): 593-619. doi: 10.1007/s00535-021-01788-x.
  • 5. Liver EA. EASL Clinical Practice Guidelines on nutrition in chronic liver disease, Journal of hepatology. 2019;70:172-93.
  • 6. Herrmann M. Assessing vitamin D metabolism - four decades of experience. Clin Chem Lab Med. 2023,61 (5): 880-94. doi: 10.1515/cclm-2022-1267.
  • 7. Türkiye Endokrinoloji ve Metabolizma Derneği. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu. 2018:119-27.
  • 8. Hossein-nezhad A, Holick MF. Vitamin D for health: A Global perspective. Mayo Clin Proc 2013; 88(7):720–55. doi:10.1016/j.mayocp. 2013.05.011.9. Börekçi NÖ. D Vitamini eksikliği ile ilgili güncel bilgiler. Jour Turk Fam Phy 2019 Cilt: 10 Sayı: 1 / e-ISSN: 2148-550X doi: 10.15511/jtfp.19.00135.
  • 10. Cederholm T, Bosaeus I, Barazzoni, R, Bauer J, Van Gossum A, Klek, S, Muscaritoli M, Nyulasi I, Ockenga J, and Schneider S. Diagnostic criteria for malnutrition–an ESPEN consensus statement, Clinical nutrition. 2015;34:335-340.
  • 11. Ulukal Karanci E. Kronik karaciğer hastalarında vitamin D düzeyinin hastalık etyolojisi ve hastalık derecesi ile ilişkisi. Uzmanlık tezi. Antalya, 2018.
  • 12. Uyanıkoğlu A. Siroz. In: Uyanıkoğlu A (ed). Pratik Gastronetroloji. 2021; 97-117.
  • 13. Giustina A, Bouillon R, Dawson-Hughes B, Ebeling PR, Lazaretti-Castro M, Lips P, Marcocci C, Bilezikian JP. Vitamin D in the older population: a consensus statement. Endocrine. 2023;79(1):31-44. doi: 10.1007/s12020-022-03208-3.
  • 14. Stokes CS, Volmer DA, Grünhage F, and Lammert F. Vitamin D in chronic liver disease, Liver International. 2013;33:338-52.
  • 15. Bemeur C, and Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications, Journal of Clinical and Experimental Hepatology. 2014;4,141-50.
  • 16. Putz-Bankuti C, Pilz S, Stojakovic T, Scharnagl H, Pieber TR, Trauner M, Obermayer-Pietsch B, Stauber RE. Association of 25-hydroxyvitamin D levels with liver dysfunction and mortality in chronic liver disease. Liver Int. 2012;32(5):845-51. doi: 10.1111/j.1478-3231.2011.02735.x.
  • 17. Fernandez Fernandez N, Linares Torres P, Joao Matias D, Jorquera Plaza F, Olcoz Goni JL. Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin D supplementation. Gastroenterol Hepatol. 2016;39(5):305-10. Spanish. doi: 10.1016/j.gastrohep.2015.10.003.
  • 18. Özman A. Kronik karaciğer hastalıklarında 25(OH) Vitamin D düzeylerinin incelenmesi. Thesis (Medical). Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, 2017.
  • 19. Yuan S, Larsson SC. Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2023;21(2):398-405.e4. doi: 10.1016/j.cgh.2022.01.021.
  • 20. Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, Sandalci O. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000;23(3):173-7.
  • 21. Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10:782.
  • 22. Uyanıkoglu A, Cindoglu C, Ciftci A, Koyuncu I, Eren M. The value of 25 (OH) and 1,25 (OH) vitamin D serum levels in newly diagnosed or on diet adult celiac patients: A case- control study. International Medicine. 2021;3:37-42. 10.5455/im.10207.

Sirotik hastalarda D vitamini eksikliği sık mı?

Year 2023, , 83 - 87, 31.12.2023
https://doi.org/10.35514/mtd.2024.98

Abstract

Amaç: Bu çalışmada kompanse ve dekompanse sirotik hastalarda, D vitamin eksiklik sıklığının kontrol grubu ile karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Karaciğer sirozu olan 80 hasta ve 80 kontrol olgusu alınmıştır. Siroz tanısı klinik, laboratuvar ve görüntüleme yöntemleri ile konulmuştur. Asit, varis kanaması, bilirubin yüksekliği dekompansasyon bulguları olarak kabul edilmiştir.
Bulgular: Sirotik 80 hastanın, 46’sı erkek (%57,5), yaş ortalaması 54,40±11,77, yaş dağılımı 18-75, kontrol grubunun 44’ü erkek (%55), yaş ortalaması 53,85±9,59, yaş dağılımı 18-75 idi.
Dekompanse sirozlu hastalarda kompanse sirozlu hastalara ve kontrol grubuna göre 10 ng/ml altında vitamin D düzey düşüklük sıklığı istatistiki olarak anlamlı düzeyde daha sık saptanırken (p<0.05), 30 ng/ml üzerinde D vitamin düzey yüksekliği dekompanse sirozda kompanse siroz ve kontrol grubuna göre anlamlı düzeyde daha düşük sıklıkta saptanmıştır (p<0.05).
Sirotik hastalarda MELD skoru, CHILD skoru ile D vitamin düzeyi arasında korelasyon saptanmadı.
Sonuç: Child evresi, MELD skoru ile D vitamini düzeyi arasında korelasyon saptanmamıştır. Dekompanse sirotik hastalarda kompanse siroz ve kontrol grubuna göre replasman gerektirecek D vitamini eksikliği daha sıktır.

References

  • 1. Hill A, Starchl C, Dresen E, Stoppe C, Amrein K. An update of the effects of vitamins D and C in critical illness. Front Med (Lausanne). 2023;9:1083760. doi: 10.3389/fmed.2022.1083760. PMID: 36726354; PMCID: PMC9885715.
  • 2. Delrue C, Speeckaert R, Delanghe JR, Speeckaert MM. Vitamin D Deficiency: An Underestimated Factor in Sepsis? Int J Mol Sci. 2023;24(3):2924. doi: 10.3390/ijms24032924.
  • 3. Moctezuma-Velazquez, C, Garcia-Juárez I, Soto-Solis R, Hernandez-Cortes J, and Torre A. Nutritional assessment and treatment of patients with liver cirrhosis, Nutrition. 2013;29:1279-85.
  • 4. Yoshiji H, Nagoshi S, Akahane T, et al. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021;56(7): 593-619. doi: 10.1007/s00535-021-01788-x.
  • 5. Liver EA. EASL Clinical Practice Guidelines on nutrition in chronic liver disease, Journal of hepatology. 2019;70:172-93.
  • 6. Herrmann M. Assessing vitamin D metabolism - four decades of experience. Clin Chem Lab Med. 2023,61 (5): 880-94. doi: 10.1515/cclm-2022-1267.
  • 7. Türkiye Endokrinoloji ve Metabolizma Derneği. Osteoporoz ve Metabolik Kemik Hastalıkları Tanı ve Tedavi Kılavuzu. 2018:119-27.
  • 8. Hossein-nezhad A, Holick MF. Vitamin D for health: A Global perspective. Mayo Clin Proc 2013; 88(7):720–55. doi:10.1016/j.mayocp. 2013.05.011.9. Börekçi NÖ. D Vitamini eksikliği ile ilgili güncel bilgiler. Jour Turk Fam Phy 2019 Cilt: 10 Sayı: 1 / e-ISSN: 2148-550X doi: 10.15511/jtfp.19.00135.
  • 10. Cederholm T, Bosaeus I, Barazzoni, R, Bauer J, Van Gossum A, Klek, S, Muscaritoli M, Nyulasi I, Ockenga J, and Schneider S. Diagnostic criteria for malnutrition–an ESPEN consensus statement, Clinical nutrition. 2015;34:335-340.
  • 11. Ulukal Karanci E. Kronik karaciğer hastalarında vitamin D düzeyinin hastalık etyolojisi ve hastalık derecesi ile ilişkisi. Uzmanlık tezi. Antalya, 2018.
  • 12. Uyanıkoğlu A. Siroz. In: Uyanıkoğlu A (ed). Pratik Gastronetroloji. 2021; 97-117.
  • 13. Giustina A, Bouillon R, Dawson-Hughes B, Ebeling PR, Lazaretti-Castro M, Lips P, Marcocci C, Bilezikian JP. Vitamin D in the older population: a consensus statement. Endocrine. 2023;79(1):31-44. doi: 10.1007/s12020-022-03208-3.
  • 14. Stokes CS, Volmer DA, Grünhage F, and Lammert F. Vitamin D in chronic liver disease, Liver International. 2013;33:338-52.
  • 15. Bemeur C, and Butterworth RF. Nutrition in the management of cirrhosis and its neurological complications, Journal of Clinical and Experimental Hepatology. 2014;4,141-50.
  • 16. Putz-Bankuti C, Pilz S, Stojakovic T, Scharnagl H, Pieber TR, Trauner M, Obermayer-Pietsch B, Stauber RE. Association of 25-hydroxyvitamin D levels with liver dysfunction and mortality in chronic liver disease. Liver Int. 2012;32(5):845-51. doi: 10.1111/j.1478-3231.2011.02735.x.
  • 17. Fernandez Fernandez N, Linares Torres P, Joao Matias D, Jorquera Plaza F, Olcoz Goni JL. Vitamin D deficiency in chronic liver disease, clinical-epidemiological analysis and report after vitamin D supplementation. Gastroenterol Hepatol. 2016;39(5):305-10. Spanish. doi: 10.1016/j.gastrohep.2015.10.003.
  • 18. Özman A. Kronik karaciğer hastalıklarında 25(OH) Vitamin D düzeylerinin incelenmesi. Thesis (Medical). Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, 2017.
  • 19. Yuan S, Larsson SC. Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2023;21(2):398-405.e4. doi: 10.1016/j.cgh.2022.01.021.
  • 20. Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, Sandalci O. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000;23(3):173-7.
  • 21. Hekimsoy Z, Dinç G, Kafesçiler S, Onur E, Güvenç Y, Pala T, et al. Vitamin D status among adults in the Aegean region of Turkey. BMC Public Health. 2010;10:782.
  • 22. Uyanıkoglu A, Cindoglu C, Ciftci A, Koyuncu I, Eren M. The value of 25 (OH) and 1,25 (OH) vitamin D serum levels in newly diagnosed or on diet adult celiac patients: A case- control study. International Medicine. 2021;3:37-42. 10.5455/im.10207.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Ahmet Uyanıkoğlu 0000-0003-4881-5244

Publication Date December 31, 2023
Submission Date April 10, 2023
Published in Issue Year 2023

Cite

Vancouver Uyanıkoğlu A. Sirotik hastalarda D vitamini eksikliği sık mı?. Maltepe tıp derg. 2023;15(3):83-7.