Examination of clinical and laboratory features of chronic infection and chronic hepatitis cases due to hepatitis B virus

Year 2021, , 57 - 60, 31.08.2021

Aziz A. Hamidi , Serhat Kescioğlu Aslı Karadeniz

https://doi.org/10.35514/mtd.2021.49

Abstract

Purpose: In the European Liver Study Association 2017 guideline, the various stages of HBV infection in the old terminology were defined as chronic infection (CI) and chronic hepatitis (CH). In this study, it was aimed to examine the clinical and laboratory features of patients with CI and CH.
Material and Methods: Between January 2019 and January 2020, the clinical and laboratory features of patients aged> 18 years who were admitted to the infectious diseases outpatient clinic with the diagnosis of chronic HBV infection were retrospectively analyzed. The cases were divided into two groups as CI and CH. The ultrasound results of the cases were examined and hepatosteatosis findings were recorded as grade 0, 1, 2 and 3.
Results: One hundred and sixty (female: 87, male: 73) cases were examined. There was no significant difference between the two groups in terms of age and gender (respectively p = 0.20; p = 021). Aspartate aminotransferase and alanine aminoteransferase was higher in the CH group then CI group (respectively p <0.001, p = 0.03) .The mean platelet value was lower in the CH group then CI gruop (p = 0.04). Grade 2 hepatosteatosis was detected in 17% of the cases in the CI group, and in 3% of the cases in the CH group (p = 0.003).
Conclusion: It was concluded that patients with CI and CH should be closely monitored by clinical laboratory and imaging methods in order to achieve diagnosis and treatment before the fibrosis stage progresses.

Keywords

Hepatitis B virus, chronic hepatitis B infection, liver fibrosis

Hepatit B virüsüne bağlı kronik infeksiyon ve kronik hepatit hastalarının klinik ve laboratuvar özelliklerinin irdelenmesi

Abstract

Amaç: Avrupa Karaciğer Çalışma Derneği 2017 kılavuzunda HBV infeksiyonun eski terminolojideki farklı evreleri, kronik infeksiyon (Kİ) ve kronik hepatit (KH) olarak tanımlanmıştır. Bu çalışmada, Kİ ve KH olan hastalarda, klinik ve laboratuvar özelliklerinin irdelenmesi amaçlanmıştır.
Materyal ve Metotlar: Ocak 2019 ile Ocak 2020 tarihleri arasında kronik HBV infeksiyonu tanısıyla polikliniğine başvuran >18 yaş olguların klinik ve laboratuvar özellikleri geriye dönük olarak incelendi. Olgular Kİ ve KH olarak iki gruba ayrıldı. Olguların ultrasonografik sonuçları incelenerek hepatosteatoz bulguları grade 0, 1, 2 ve 3 olarak kaydedildi.
Bulgular: Yüz altmış (kadın: 87, erkek: 73) hasta incelenmiştir. Her iki grup arasında yaş ve cinsiyet açısından anlamlı bir fark bulunmadı (sırsıyla p=0.20; p=021). Aspartat aminotransferaz AST) ve alanin aminoteransferaz (ALT) KH grubunda Kİ grubuna göre daha yüksek bulundu (sırasıyla p<0,001, p=0,03). Ortalama trombosit değeri KH grubunda, Kİ grubuna göre daha düşük saptandı (p=0,04). Kİ grubunda evre 2 hepatosteatoz olguların %17’sinde saptanırken KH grubunda olguların %3’ünde saptandı (p=0,003).
Sonuç: Kİ ve KH olan hastaların fibroz evresinin ilerlemeden tanı ve tedaviye ulaşması için klinik laboratuvar ve görüntüleme yöntemleriyle yakından izlenmesinin gerekli olduğu kanısına varılmıştır.

Keywords

Hepatit B virüsü, kronik hepatit B infeksiyonu, karaciğer fibrozu

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