BibTex RIS Cite

Cerrahi girişimler ve immünsüpresyon

Year 2014, Volume: 6 Issue: 3, 1 - 4, 01.12.2014

Abstract

iSurgical operations generate a variety of metabolic and endocrine responses which cause immunosuppression in the postoperative period. This general state of immunosuppression may result in septic complications and tumor metastasis formation. Understanding the mechanisms underlying, make the surgeons and anaesthetists to develop strategies in order to minimise this effect

References

  • Ogawa K, Hirai M, Katsube T, et al. Suppres- sion of cellular immunity by surgical stress. Surgery 2000;127(3):329-336.
  • Leaver HA, Craig SR, Yap PL, Walker WS. Lym- phocyte responses following open and mini- mally invasive thoracic surgery. Eur J Clin Invest 2000;30(3):230-238.
  • Toft P, Lillevang ST, Tİnnesen E, Svendsen P, Ho¨hndorf K. Redistribution of lymphocytes following E. coli sepsis. Scand J Immunol 1993;38(6):541-545.
  • Cristaldi M, Rovati M, Elli M, Gerlinzani S, Les- ma A, Balzarotti L, et al. Lymphocytic subpop- ulation changes after open and laparoscopic cholecystectomy: a prospective and compar- ative study on 38 patients. Surg Laparosc Endosc 1997;7(3):255-261.
  • Wichmann MW, Hüttl TP, Winter H, et al. Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study. Arch Surg 2005;140(7):692-697.
  • Kawasaki T, Ogata M, Kawasaki C, Okamoto K, Sata T. Effects of epidural anaesthesia on surgical stress-induced immunosuppression during upper abdominal surgery. Br J Anaesth 2007;98(2):196-203.
  • Synder GL, Greenkey S.Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 2010; 105 (2): 106-115.
  • Wu GJ, Tai YT, Chen TL, Lin LL, Ueng YF, Chen RM. Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophag- es. Ann N Y Acad Sci 2005;1042:168-176.
  • Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology 2003; 98(5):1178-1185.
  • Brune IB, Wilke W, Hensler T, Feussner H, Holz- mann B, Siewert JR. Normal T lymphocyte and monocyte function after minimally invasive surgery. Surg Endosc 1998;12(8): 1020-1024.
  • Kennedy BC, Hall GM. Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg 1999;50(4):205-209
  • Larsson EL. Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process. J Immunol 1980;124(6):2828-2833.
  • Arya SK, Wong-Staal F, Gallo RC. Dexameth- asone-mediated inhibition of human T cell growth factor and gammainterferon messen- ger RNA. J Immunol 1984;133(1):273-276.
  • Nieto MA,Gonza´lez A, Gambo´nF,Dı´az-Espa- da F, Lo´pez-Rivas A. Apoptosis in human thy- mocytes after treatment with glucocorticoids. Clin Exp Immunol 1992;88(2):341-344.
  • Sallenave JM, Shulmann J, Crossley J, Jordana M, Gauldie J. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol 1994;11(6):733-741.
  • Mulligan MS, Lentsch AB, Huber-Lang M, Guo RF, Sarma V, Wright CD. Anti-inflammatory effects of mutant forms of secretory leuko- cyte protease inhibitor. Am J Pathol 2000;156 (3):1033-1039.
  • Mozo L, Gayo A, Sua´ rez A, Rivas D, Zamora- no J, Gutie´rrez C. Glucocorticoids inhibit IL-4 and mitogen-induced IL-4R alpha chain expres- sion by different posttranscriptional mecha- nisms. J Allergy Clin Immunol 1998;102 (6 Pt 1):968-976.
  • de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine JD. Beta 2-adrenergic recep- tor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol 2004; 143(8):1033-1041.
  • Tamir A, Isakov N. Cyclic AMP inhibits phos- phatidylinositol coupled and uncoupled mito- genic signals in T lymphocytes. Evidence that cAMP alters PKC-induced transcription regula- tion of members of the jun and fos family of genes.J Immunol 1994;152(7):3391-3399.
  • Bloemen PG, van den Tweel MC, Henricks PA, et al. Increased cAMP levels in stimulated neu- trophils inhibit their adhesion to human bron- chial epithelial cells. Am J Physiol 1997;272(4 Pt 1):L580-587.
  • Kitamura T, Ohno N, Bougaki M, Ogawa M, Yamada Y. Comparison of the effects of sevo- flurane and propofol on changes in leuko- cyte-count induced by surgical stress. Masui 2008;57(8):968-972.
  • Le Cras AE, Galley HF, Webster NR. Spinal but not general anesthesia increases the ratio of T helper 1 to T helper 2 cell subsets in patients undergoing transurethral resection of the prostate. Anesth Analg 1998;87(6):1421-1425.
  • Fuchs BA, Pruett SB. Morphine induces apop- tosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glu- cocorticoid receptors. J Pharmacol Exp Ther 1993; 266(1):417-423.
  • Graham EA. The influence of ether and ether anaesthesia on bacteriolysis, agglutination, and phagocytosis. J Infect Dis 1911;8:147-175.
  • Tartter PI, Steinberg B, Barron DM, Martinelli G. The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer. Arch Surg 1987;122(11):1264-1268.
  • Levy SM, Herberman RB, Maluish AM, Schlien B, Lippman M. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 1985;4(2):99-113.
  • Fujisawa T, Yamaguchi Y. Autologous tumor killing activity as a prognostic factor in primary resected nonsmall cell carcinoma of the lung. Cancer 1997;79(3):474-481.
  • Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 1993;80(2):205-209.
  • Ahlers O, Nachtigall I, Lenze J, Goldmann A, Schulte E, Ho¨hne C, et al. Intraoperative tho- racic epidural anaesthesia attenuates stress-in- duced immunosuppression in patients under- going major abdominal surgery. Br J Anaesth 2008;101 (6):781-787.
  • Page GG, Blakely WP, Ben-Eliyahu S. Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain 2001;90(1-2):191-199.
  • Mahdy AM, Galley HF, Abdel-Wahed MA, el-Korny KF, Sheta SA, Webster NR. Differential modulation of interleukin- 6 and interleukin-10 by diclofenac in patients undergoing major surgery. Br J Anaesth 2002;88(6):797-802.
  • Kendall SJ, Weir J, Aspinall R, Henderson D, Rosson J. Erythrocyte transfusion causes im- munosuppression after total hip replacement. Clin Orthop Relat Res 2000;(381):145-155.
  • Wang G, Jiang Z, Zhao K, Li G, Liu F, Pan H, Li J. Immunologic response after laparoscopic colon cancer operation within an enhanced recovery program.J Gastrointest Surg 2012; 16(7): 1379-1388.
  • Bobocea AC, Trandafir B, Bolca C, Cordoş I. Minimally invasive surgery in cancer. Immu- nological response.Chirurgia 2012; 107(2): 154-157.
  • Smyth MJ, Taniguchi M, Street SE. The anti-tu- mor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol 2000;165(5):2665-2670.
  • Kobayashi T, Shiiba K, Satoh M, et al. Inter- leukin-12 administration is more effective for preventing metastasis than for inhibiting primary established tumors in a murine model of spontaneous hepatic metastasis. Surg Today 2002;32(3):236-242.
  • Schwartz Y, Avraham R, Benish M, Rosenne E, Ben-Eliyahu S. Prophylactic IL-12 treatment reduces postoperative metastasis: mediation by increased numbers but not cytotoxicity of NK cells. Breast Cancer Res Treat 2008;107(2): 211-223.
  • Caprotti R, Brivio F, Fumagalli L, et al. Free-from-progression period and overall short preoperative immunotherapy with IL-2 increas- es the survival of pancreatic cancer patients treated with macroscopically radical surgery. Anticancer Res 2008;28(3B):1951-1954.
  • Hsueh EC, Essner R, Foshag LJ, et al. Prolonged survival after complete resection of dissemi- nated melanoma and active immunotherapy with a therapeutic cancer vaccine. J Clin Oncol 2002;20(23): 4549-4554.

Cerrahi girişimler ve immünsüpresyon

Year 2014, Volume: 6 Issue: 3, 1 - 4, 01.12.2014

Abstract

Cerrahi girişimler postoperatif dönemde immünsüpresyona neden olan bir çok metabolik ve endokrin yanıt oluşturmaktadır. Bu genel immünsüpresyon durumu septik komplikasyonlar ve tümör metastaz oluşumuna yol açabilmektedir. Altta yatan mekanizmaların anlaşılması, bu etkiyi azaltmak için gerekli stratejilerin oluşturulmasını sağlayacaktır.

References

  • Ogawa K, Hirai M, Katsube T, et al. Suppres- sion of cellular immunity by surgical stress. Surgery 2000;127(3):329-336.
  • Leaver HA, Craig SR, Yap PL, Walker WS. Lym- phocyte responses following open and mini- mally invasive thoracic surgery. Eur J Clin Invest 2000;30(3):230-238.
  • Toft P, Lillevang ST, Tİnnesen E, Svendsen P, Ho¨hndorf K. Redistribution of lymphocytes following E. coli sepsis. Scand J Immunol 1993;38(6):541-545.
  • Cristaldi M, Rovati M, Elli M, Gerlinzani S, Les- ma A, Balzarotti L, et al. Lymphocytic subpop- ulation changes after open and laparoscopic cholecystectomy: a prospective and compar- ative study on 38 patients. Surg Laparosc Endosc 1997;7(3):255-261.
  • Wichmann MW, Hüttl TP, Winter H, et al. Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study. Arch Surg 2005;140(7):692-697.
  • Kawasaki T, Ogata M, Kawasaki C, Okamoto K, Sata T. Effects of epidural anaesthesia on surgical stress-induced immunosuppression during upper abdominal surgery. Br J Anaesth 2007;98(2):196-203.
  • Synder GL, Greenkey S.Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth 2010; 105 (2): 106-115.
  • Wu GJ, Tai YT, Chen TL, Lin LL, Ueng YF, Chen RM. Propofol specifically inhibits mitochondrial membrane potential but not complex I NADH dehydrogenase activity, thus reducing cellular ATP biosynthesis and migration of macrophag- es. Ann N Y Acad Sci 2005;1042:168-176.
  • Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology 2003; 98(5):1178-1185.
  • Brune IB, Wilke W, Hensler T, Feussner H, Holz- mann B, Siewert JR. Normal T lymphocyte and monocyte function after minimally invasive surgery. Surg Endosc 1998;12(8): 1020-1024.
  • Kennedy BC, Hall GM. Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg 1999;50(4):205-209
  • Larsson EL. Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process. J Immunol 1980;124(6):2828-2833.
  • Arya SK, Wong-Staal F, Gallo RC. Dexameth- asone-mediated inhibition of human T cell growth factor and gammainterferon messen- ger RNA. J Immunol 1984;133(1):273-276.
  • Nieto MA,Gonza´lez A, Gambo´nF,Dı´az-Espa- da F, Lo´pez-Rivas A. Apoptosis in human thy- mocytes after treatment with glucocorticoids. Clin Exp Immunol 1992;88(2):341-344.
  • Sallenave JM, Shulmann J, Crossley J, Jordana M, Gauldie J. Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes. Am J Respir Cell Mol Biol 1994;11(6):733-741.
  • Mulligan MS, Lentsch AB, Huber-Lang M, Guo RF, Sarma V, Wright CD. Anti-inflammatory effects of mutant forms of secretory leuko- cyte protease inhibitor. Am J Pathol 2000;156 (3):1033-1039.
  • Mozo L, Gayo A, Sua´ rez A, Rivas D, Zamora- no J, Gutie´rrez C. Glucocorticoids inhibit IL-4 and mitogen-induced IL-4R alpha chain expres- sion by different posttranscriptional mecha- nisms. J Allergy Clin Immunol 1998;102 (6 Pt 1):968-976.
  • de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine JD. Beta 2-adrenergic recep- tor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol 2004; 143(8):1033-1041.
  • Tamir A, Isakov N. Cyclic AMP inhibits phos- phatidylinositol coupled and uncoupled mito- genic signals in T lymphocytes. Evidence that cAMP alters PKC-induced transcription regula- tion of members of the jun and fos family of genes.J Immunol 1994;152(7):3391-3399.
  • Bloemen PG, van den Tweel MC, Henricks PA, et al. Increased cAMP levels in stimulated neu- trophils inhibit their adhesion to human bron- chial epithelial cells. Am J Physiol 1997;272(4 Pt 1):L580-587.
  • Kitamura T, Ohno N, Bougaki M, Ogawa M, Yamada Y. Comparison of the effects of sevo- flurane and propofol on changes in leuko- cyte-count induced by surgical stress. Masui 2008;57(8):968-972.
  • Le Cras AE, Galley HF, Webster NR. Spinal but not general anesthesia increases the ratio of T helper 1 to T helper 2 cell subsets in patients undergoing transurethral resection of the prostate. Anesth Analg 1998;87(6):1421-1425.
  • Fuchs BA, Pruett SB. Morphine induces apop- tosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glu- cocorticoid receptors. J Pharmacol Exp Ther 1993; 266(1):417-423.
  • Graham EA. The influence of ether and ether anaesthesia on bacteriolysis, agglutination, and phagocytosis. J Infect Dis 1911;8:147-175.
  • Tartter PI, Steinberg B, Barron DM, Martinelli G. The prognostic significance of natural killer cytotoxicity in patients with colorectal cancer. Arch Surg 1987;122(11):1264-1268.
  • Levy SM, Herberman RB, Maluish AM, Schlien B, Lippman M. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychol 1985;4(2):99-113.
  • Fujisawa T, Yamaguchi Y. Autologous tumor killing activity as a prognostic factor in primary resected nonsmall cell carcinoma of the lung. Cancer 1997;79(3):474-481.
  • Wakefield CH, Carey PD, Foulds S, Monson JR, Guillou PJ. Changes in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 1993;80(2):205-209.
  • Ahlers O, Nachtigall I, Lenze J, Goldmann A, Schulte E, Ho¨hne C, et al. Intraoperative tho- racic epidural anaesthesia attenuates stress-in- duced immunosuppression in patients under- going major abdominal surgery. Br J Anaesth 2008;101 (6):781-787.
  • Page GG, Blakely WP, Ben-Eliyahu S. Evidence that postoperative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain 2001;90(1-2):191-199.
  • Mahdy AM, Galley HF, Abdel-Wahed MA, el-Korny KF, Sheta SA, Webster NR. Differential modulation of interleukin- 6 and interleukin-10 by diclofenac in patients undergoing major surgery. Br J Anaesth 2002;88(6):797-802.
  • Kendall SJ, Weir J, Aspinall R, Henderson D, Rosson J. Erythrocyte transfusion causes im- munosuppression after total hip replacement. Clin Orthop Relat Res 2000;(381):145-155.
  • Wang G, Jiang Z, Zhao K, Li G, Liu F, Pan H, Li J. Immunologic response after laparoscopic colon cancer operation within an enhanced recovery program.J Gastrointest Surg 2012; 16(7): 1379-1388.
  • Bobocea AC, Trandafir B, Bolca C, Cordoş I. Minimally invasive surgery in cancer. Immu- nological response.Chirurgia 2012; 107(2): 154-157.
  • Smyth MJ, Taniguchi M, Street SE. The anti-tu- mor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J Immunol 2000;165(5):2665-2670.
  • Kobayashi T, Shiiba K, Satoh M, et al. Inter- leukin-12 administration is more effective for preventing metastasis than for inhibiting primary established tumors in a murine model of spontaneous hepatic metastasis. Surg Today 2002;32(3):236-242.
  • Schwartz Y, Avraham R, Benish M, Rosenne E, Ben-Eliyahu S. Prophylactic IL-12 treatment reduces postoperative metastasis: mediation by increased numbers but not cytotoxicity of NK cells. Breast Cancer Res Treat 2008;107(2): 211-223.
  • Caprotti R, Brivio F, Fumagalli L, et al. Free-from-progression period and overall short preoperative immunotherapy with IL-2 increas- es the survival of pancreatic cancer patients treated with macroscopically radical surgery. Anticancer Res 2008;28(3B):1951-1954.
  • Hsueh EC, Essner R, Foshag LJ, et al. Prolonged survival after complete resection of dissemi- nated melanoma and active immunotherapy with a therapeutic cancer vaccine. J Clin Oncol 2002;20(23): 4549-4554.
There are 39 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Zeliha Özer This is me

Onur Selvi This is me

Publication Date December 1, 2014
Published in Issue Year 2014 Volume: 6 Issue: 3

Cite

Vancouver Özer Z, Selvi O. Cerrahi girişimler ve immünsüpresyon. Maltepe tıp derg. 2014;6(3):1-4.