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A view to lung metastases in the light of clinical experiences

Year 2013, Volume: 5 Issue: 2, 14 - 20, 01.08.2013

Abstract

Metastases of the malignant tumors are related with their differentiation degrees. Primary tumors can be controlled locally with chemo/radiotherapy, but systemic metastases have some difficulties in treatment. Lung metastases also have exclusive pattern. Cure of the primary cancer and a long-term survival are the main purposes. If the primary cancer is under control and there is no spreading pulmonary metastasectomy is the curative treatment option in appropriate patients with low morbidity and mortality rates. We report our metastatic cases with a short literature review.

References

  • Putnam JB. Pulmonary Metastases. In: Fran- co KL, Putnam JB; eds. Advanced Theraphy in Thoracic Surgery. Ontario: BC Decker Company; 1998:117-126.
  • Putnam JB. Secondary tumors of the lung. In: Shields TW, Locicero J, Ponn RB editors. General thoracic surgery. Fifth ed. Philadelphia: Lippincott Williams & Wilkins; 2000:1555 - 1576.
  • Shields TW. B. Pathology of carcinoma of the lung. In: Shields TW, LoCicero J, Ponn RB, editors. General thoracic surgery. Philadelphia: Lippincott Williams & Wilkins; 2000:1235-1268.
  • Monteiro A, Arce N, Bernardo J, et al. Surgical re- section of lung metastases from epithelial tumors. Ann Thorac Surg 2004;77:431-437.
  • Yüksel M, Kalaycı G. Metastatik akciğer tümörleri. In: Yüksel M, Kalaycı G (eds). Göğüs Cerrahisi. İs- tanbul: Bilmedya Grup, 2001:307-328.
  • Rusch VW. Pulmonary metastasectomy: current indications. Chest 1995;107(6):322-331.
  • Abecasis N, Cortez F, Bettencourt A, et al. Surgical treatment of lung metastases: prognostic factors for long-term survival. J Surg Oncol 1999;72:193-198.
  • Venn GE, Sarin S, Goldsraw P. Survival following pul- monary metastasectomy. Eur J Cardiothorac Surg 1989;3:105-109.
  • Fourquier P, Regnard JF, Rea S, et al. Lung metastases of renal cell carcinoma: results of surgical resection. Eur J Cardiothorac Surg 1997;11:17-21.
  • Mountain CF, McMurtrey MJ, Hermes KE. Surgery for pulmonary metastasis: a 20-year experience. Ann Thorac Surg 1984;38:323-330.
  • Lien HH, Lindskold L, Fossa SD, et al. Computed to- mog- raphy and conventional radiography in intrat- horacic metas- tases from non-seminomatous testi- cular tumor. Acta Radiol 1988;29:547-549.
  • Lucas JD, O’Doherty MJ, Wong JC, et al. Evaluation of fluorodeoxyglucose positron emission tomog- raphy in the management of soft-tissue sarcomas. J Bone Joint Surg 1998;80:441-447.
  • Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analy- ses based on 5206 cases. J Thorac Cardiovasc Surg 1997;113:37-49.
  • Kondo H, Okumura T, Ohde Y, et al. Surgical treat- ment for metastatic malignancies. Pulmonary me- tastasis: indications and outcomes. Int J Clin Oncol 2005;10:81-85.
  • Parsons AM, Detterbeck FC, Parker LA. Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary? Ann Tho- rac Surg 2004;78:1910-1918.
  • Mineo TC, Ambrogi V, Paci M, et al. Transxip- hoid bilateral palpation in video-assisted tho- racoscopic lung metastasectomy. Arch Surg 2001;136:783-788.
  • Lin JC, Wiechmann RJ, Szwerc MF, et al. Diag- nostic and therapeutic VATS resection of pul- monary metastases. Surgery 1999;126:636- 642.
  • Nakajima J, Takamoto S, Tanaka M, et al. Thora- coscopic surgery and conventional open thora- cotomy in metastatic lung cancer. Surg Endosc 2001;15:849-853.
  • Goorin AM, Shuster JJ, Baker A. et al. Changing pattern of pulmonary metastases with adjuvant chemotherapy in patients with osteosarcoma: Results from the multi-institutional osteosarco- ma study. J Clin Oncol 1991;9:600-605.
  • Van Geel AN, Pastorino U, Jauch KW, et al. Sur- gical treatment of lung metastases: The Euro- pean Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer 1996;77(4):675- 682.
  • Connolly JE, Erasmus JJ, Patz EF. Thoracic ma- nifestations of breast carcinoma: metastatic di- sease and complications of treatment Clinical Radiology 1999;54:487-494.
  • Lanza LA, Natarajan G, Roth JA, et al. Long term survival after resection of pulmonary me- tastases from carcinoma of the breast. Ann Thorac Surg 1992;52:244-247.
  • Staren ED, Salerno C, Rongione A, et al. Pul- monary resection for metastatic breast cancer. Arch Surg 1992;127:1282-1284.
  • Robinson BJ, Rice TW, Strong SA, et al. Is re- section of pulmonary and hepatic metastases warranted in patients with colorectal cancer? JThorac Cardiovasc Surg 1999;117:66-75.
  • Friedel G, Linder A, Toomes H. The significance of prognostic factors for the resection of pul- monary metastases of breast cancer. Thorac Cardiovasc Surg 1994;42:71-75.
  • Koong HN, Pastorino U, Ginsberg RJ. Is there a role for pneumonectomy in pulmonary metas- tases? Ann Thorac Surg 1999;68:1039-1043.
  • Kodama K, Doi O, Higashiyama M, et al. Surgi- cal management of lung metastases. Usefulness of resection with the neodymium:yttrium-alu- minum-garnet laser with median sternotomy. J Thorac cardiovasc Surg 1991;101:901-908.

Klinik deneyim ile akciğer metastatik tümörlerine bakış

Year 2013, Volume: 5 Issue: 2, 14 - 20, 01.08.2013

Abstract

Malign tümörler farklılaşma derecesine göre yayılma eğilimindedir. Primer odaklar cerrahi veya kemo/ radyoterapi ile lokal olarak kontrol altına alınabilir, ancak sistemik metastaz olması durumunda tedavi sıkıntılı olmaktadır. Akciğerin metastatik tümörleri, primer malign tümörün sistemik metastazının bir parçası olmakla birlikte sahip olduğu özellikleri ile ayrı olarak incelenmesi gereken bir konudur. Metastazların rezeksiyonunda iki ana amaç; hastalığın kürü ve hastalıksız yaşam süresinin uzatılmasıdır. Akciğer metastatik tümörlerinde primer malignite kontrol altında, başka yayılım yok ve hastanın genel durumu uygun ise metastazektomi düşük mortalite ile güvenle uygulanabilen potansiyel olarak küratif bir tedavi şeklidir. Kliniğimizde bu düşünce ile uygun hastalarda yaptığımız metastazektomileri genel bilgiler ışığında sunmayı amaçladık.

References

  • Putnam JB. Pulmonary Metastases. In: Fran- co KL, Putnam JB; eds. Advanced Theraphy in Thoracic Surgery. Ontario: BC Decker Company; 1998:117-126.
  • Putnam JB. Secondary tumors of the lung. In: Shields TW, Locicero J, Ponn RB editors. General thoracic surgery. Fifth ed. Philadelphia: Lippincott Williams & Wilkins; 2000:1555 - 1576.
  • Shields TW. B. Pathology of carcinoma of the lung. In: Shields TW, LoCicero J, Ponn RB, editors. General thoracic surgery. Philadelphia: Lippincott Williams & Wilkins; 2000:1235-1268.
  • Monteiro A, Arce N, Bernardo J, et al. Surgical re- section of lung metastases from epithelial tumors. Ann Thorac Surg 2004;77:431-437.
  • Yüksel M, Kalaycı G. Metastatik akciğer tümörleri. In: Yüksel M, Kalaycı G (eds). Göğüs Cerrahisi. İs- tanbul: Bilmedya Grup, 2001:307-328.
  • Rusch VW. Pulmonary metastasectomy: current indications. Chest 1995;107(6):322-331.
  • Abecasis N, Cortez F, Bettencourt A, et al. Surgical treatment of lung metastases: prognostic factors for long-term survival. J Surg Oncol 1999;72:193-198.
  • Venn GE, Sarin S, Goldsraw P. Survival following pul- monary metastasectomy. Eur J Cardiothorac Surg 1989;3:105-109.
  • Fourquier P, Regnard JF, Rea S, et al. Lung metastases of renal cell carcinoma: results of surgical resection. Eur J Cardiothorac Surg 1997;11:17-21.
  • Mountain CF, McMurtrey MJ, Hermes KE. Surgery for pulmonary metastasis: a 20-year experience. Ann Thorac Surg 1984;38:323-330.
  • Lien HH, Lindskold L, Fossa SD, et al. Computed to- mog- raphy and conventional radiography in intrat- horacic metas- tases from non-seminomatous testi- cular tumor. Acta Radiol 1988;29:547-549.
  • Lucas JD, O’Doherty MJ, Wong JC, et al. Evaluation of fluorodeoxyglucose positron emission tomog- raphy in the management of soft-tissue sarcomas. J Bone Joint Surg 1998;80:441-447.
  • Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analy- ses based on 5206 cases. J Thorac Cardiovasc Surg 1997;113:37-49.
  • Kondo H, Okumura T, Ohde Y, et al. Surgical treat- ment for metastatic malignancies. Pulmonary me- tastasis: indications and outcomes. Int J Clin Oncol 2005;10:81-85.
  • Parsons AM, Detterbeck FC, Parker LA. Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary? Ann Tho- rac Surg 2004;78:1910-1918.
  • Mineo TC, Ambrogi V, Paci M, et al. Transxip- hoid bilateral palpation in video-assisted tho- racoscopic lung metastasectomy. Arch Surg 2001;136:783-788.
  • Lin JC, Wiechmann RJ, Szwerc MF, et al. Diag- nostic and therapeutic VATS resection of pul- monary metastases. Surgery 1999;126:636- 642.
  • Nakajima J, Takamoto S, Tanaka M, et al. Thora- coscopic surgery and conventional open thora- cotomy in metastatic lung cancer. Surg Endosc 2001;15:849-853.
  • Goorin AM, Shuster JJ, Baker A. et al. Changing pattern of pulmonary metastases with adjuvant chemotherapy in patients with osteosarcoma: Results from the multi-institutional osteosarco- ma study. J Clin Oncol 1991;9:600-605.
  • Van Geel AN, Pastorino U, Jauch KW, et al. Sur- gical treatment of lung metastases: The Euro- pean Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer 1996;77(4):675- 682.
  • Connolly JE, Erasmus JJ, Patz EF. Thoracic ma- nifestations of breast carcinoma: metastatic di- sease and complications of treatment Clinical Radiology 1999;54:487-494.
  • Lanza LA, Natarajan G, Roth JA, et al. Long term survival after resection of pulmonary me- tastases from carcinoma of the breast. Ann Thorac Surg 1992;52:244-247.
  • Staren ED, Salerno C, Rongione A, et al. Pul- monary resection for metastatic breast cancer. Arch Surg 1992;127:1282-1284.
  • Robinson BJ, Rice TW, Strong SA, et al. Is re- section of pulmonary and hepatic metastases warranted in patients with colorectal cancer? JThorac Cardiovasc Surg 1999;117:66-75.
  • Friedel G, Linder A, Toomes H. The significance of prognostic factors for the resection of pul- monary metastases of breast cancer. Thorac Cardiovasc Surg 1994;42:71-75.
  • Koong HN, Pastorino U, Ginsberg RJ. Is there a role for pneumonectomy in pulmonary metas- tases? Ann Thorac Surg 1999;68:1039-1043.
  • Kodama K, Doi O, Higashiyama M, et al. Surgi- cal management of lung metastases. Usefulness of resection with the neodymium:yttrium-alu- minum-garnet laser with median sternotomy. J Thorac cardiovasc Surg 1991;101:901-908.
There are 27 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Uğur Temel This is me

Aslı Gül Akgül This is me

Selçuk Fatih Biricik This is me

Ahmet Uyanoğlu This is me

Hikmet Fatih Özvar This is me

Publication Date August 1, 2013
Published in Issue Year 2013 Volume: 5 Issue: 2

Cite

Vancouver Temel U, Akgül AG, Biricik SF, Uyanoğlu A, Özvar HF. Klinik deneyim ile akciğer metastatik tümörlerine bakış. Maltepe tıp derg. 2013;5(2):14-20.