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The Effects of Diabetes Mellitus and Obesity to Pelvic Organ Prolapse in Postmenopausal Women

Year 2011, Volume: 3 Issue: 1, 21 - 27, 01.04.2011

Abstract

Objective: We aim to evaluate the effect of diabetes and obesity on pelvic organ prolapse POP in postmenopausal women. Methods: 104 women with POP, ages 49 to 79 were divided as group I non diabetic-non obese , group II non obese-diabetic , group III obese-non diabetic and group IV obese-diabetic . For each group, presence of uterine prolapse, cystocele and rectocele using POP Quantification POP-Q system were assessed. Results: Obesity and diabetes mellitus DM were associated with progression in cystocoele, rectocele and uterine prolapse compared with healthy women p

References

  • 1) Gerten KA, Markland AD, Lloyd LK, Richter HE.: Prolapse and incontinence surgery in older women. J Urol 2008; 179:2111-2118.
  • 2) MacLennan AH, Taylor AW, Wilson DH, Wilson D.: The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery. Br J Obstet Gynaecol 2000;107:1460–1470.
  • 3) Bump RC, Norton PA.: Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am 1998; 25:723–746.
  • 4) Mant J, Painter R, Vessey M.: Epidemiology of genital prolapse: observations from the Oxford Family Planning Association Study. Br J Obstet Gynaecol 1997; 104:579-585.
  • 5) Progetto Menopausa Italia Study Group. Risk factors for genital prolapse in non-hysterectomized women around menopause: results from a large crosssectional study in menopausal clinics in Italy. Eur J Obstet Gynecol Reprod Biol 2000; 93:135-140.
  • 6) Nygaard I, Bradley C, Brandt D.: Women’s Health Initiative. Pelvic organ prolapse in older women: prevalence and risk factors. Obstet Gynecol 2004;104:489-497.
  • 7) Goldstein SR, Neven P, Zhou L, Taylor YL, Ciaccia AV, Plouffe L.: Raloxifene effect on frequency of surgery for pelvic floor relaxation. Obstet Gynecol 2001; 98: 91-96.
  • 8) Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A.: Pelvic organ prolapse in the Women’s Health Initiative: gravity and gravidity. Am J Obstet Gynecol 2002; 186:1160+1166.
  • 9) Mant J, Painter R, Vessey M.: Epidemiology of genital prolapse: observations from the Oxford family planning association study. BJOG 1997; 104: 579- 585. 10) Moalli PA, Jones Ivy S, Meyn LA, Zyczynski HM. Risk factors associated with pelvic floor disorders in women undergoing surgical repair. Obstet Gynecol 2003; 101: 869-874.
  • 11) Luber KM, Boero S, Choe JY.: The demographics of pelvic floor disorders: current observations and future projections. Am J Obstet Gynecol 2001; 184:1496- 1501.
  • 12) Sampselle CM, Wyman JF, Thomas KK, Newman DK, Gray M, Dougherty M, et al.: Continence for women: evaluation of AWHONN's third research utilization project. Association of Women's Health Obstetric and Neonatal Nurses. J Obstet Gynecol Neonatal Nurs 2000; 29:9-17.
  • 13) American College of Obstetricians and Gynecologists. Pelvic organ prolapse. ACOG Technical Bulletin 214. Washington, DC: ACOG. 1995.
  • 14) Bump RC, Mattiasson A, Bo K.: The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 1996; 175:10-17.
  • 15) Blakeman A, Hilton A, Bulmer JN.: Mapping oestrogen and progesterone receptors throughout the female lower urinary tract. Abstracts from the 26th Annual Meeting of the International Continence Society. Neurologic Urodynamics 1996; 15:324-325.
  • 16) Cicinelli E, Einer-Jensen N, Galantino P, Pinto V, Barba B, Tartangni M.: Model of counter-current transfer from vagina to urethra in postmenopausal women.Human Reproduction 2001; 16:2496-2500.
  • 17) Robinson D, Cardozo L.: The role of estrogens in female lower urinary tract dysfunction. Urology 2003; 62:45-51.
  • 18) Vardy M, Lindsay R, Scotti R, Mikhail M, Richart R, Nieves J, et al.: Short-term urogenital effects of raloxifene, tamoxifen, and estrogen. Am J Obstet Gynecol 2003; 189:81-88.
  • 19) Kim SW, Kim NN, Jeong SJ, Munarriz R, Goldstein I, Traish AM.: Modulation of rat vaginal blood flow and estrogen receptor by estradiol. J Urol 2004; 172:1538-1543.
  • 20) Pessina, MA; Hoyt, RF; Goldstein, I; Traish, AM.: Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrity. Endocrinol.ogy 2006;147:161-169.
  • 21) Christ GJ, Hodges S.: Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol 2006; 147 : 41-55.
  • 22) Daneshgari F, Moore C.: Diabetic uropathy. Semin Nephrol 2006; 26:182-185.
  • 23) Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA.: Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 2002; 187:56-63.
  • 24) Lin SY, Tee YT, Ng SC, Chang H, Lin PP, Chen GD.: Changes in the extracellular matrix in the anterior vagina of women with or without prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2006; 18:43-48.
  • 25) Wong MY, Harmanli OH, Agar M, Dandolu V, Grody MHT.: Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence. Am J Obstet Gynecol 2003; 189:1597-1600.
  • 26) Norton PA.: Pelvic floor disorders: The role of fascia and ligaments. Clin Obstet Gynecol 1993; 36:926- 938.
  • 27) Lubowski DZ, Swash M, Nicholls RJ, Henry MM.: Increase in pudendal nerve terminal motor latency with defaecation straining. Br J Surg 1988; 75:1095- 1097.
  • 28) Sapsford RR, Hodges PW.: Contraction of the pelvic floor muscles during abdominal maneuvers. Arch Phys Med Rehabil 2001; 82:1081-1088.
  • 29) Moalli PA, Ivy SJ, Meyn LA, Zyczynski HM.: Risk factors associated with pelvic floor disorders in women undergoing surgical repair. Obstet Gynecol 2003;101:869-874.
  • 30) Lawrence JM, Charles WN, Emily SL, Karl ML, In-Lu AL.: Pelvic Floor Disorders, Diabetes, and Obesity in Women. Diabetes Care 2007; 30:2536-2541.

Diabetes Mellitus ve Obezitenin Postmenopozal Dönemdeki Kadınlardaki Pelvik Organ Prolapsusu Üzerine Etkileri

Year 2011, Volume: 3 Issue: 1, 21 - 27, 01.04.2011

Abstract

Amaç: Diabetes mellitus ve obezitenin postmenopozal dönemdeki kadınlarda pelvik organ prolapsusuna POP olan etkilerini değerlendirmeyi amaçladık. Yöntemler: 49-79 yaşları arasındaki POP bulunan 104 kadın grup I non-diabetik ve non-obez grup II non-obez ve diabetik grup III obez ve non-diabetik ve grup IV obez ve diabetik olmak üzere 4 gruba ayrılmıştır. Her bir grupta POP-Q POP-Q sistemi kullanılarak uterin prolapsus, sistosel ve rektosel varlığı değerlendirildi. Bulgular: Sağlıklı kadınlarla karşılaştırıldığında obezitenin ve diabetes mellitusun DM sistosel, rektosel ve uterin prolapsus progresyonuyla ilişkili olduğu saptanmıştır p

References

  • 1) Gerten KA, Markland AD, Lloyd LK, Richter HE.: Prolapse and incontinence surgery in older women. J Urol 2008; 179:2111-2118.
  • 2) MacLennan AH, Taylor AW, Wilson DH, Wilson D.: The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery. Br J Obstet Gynaecol 2000;107:1460–1470.
  • 3) Bump RC, Norton PA.: Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am 1998; 25:723–746.
  • 4) Mant J, Painter R, Vessey M.: Epidemiology of genital prolapse: observations from the Oxford Family Planning Association Study. Br J Obstet Gynaecol 1997; 104:579-585.
  • 5) Progetto Menopausa Italia Study Group. Risk factors for genital prolapse in non-hysterectomized women around menopause: results from a large crosssectional study in menopausal clinics in Italy. Eur J Obstet Gynecol Reprod Biol 2000; 93:135-140.
  • 6) Nygaard I, Bradley C, Brandt D.: Women’s Health Initiative. Pelvic organ prolapse in older women: prevalence and risk factors. Obstet Gynecol 2004;104:489-497.
  • 7) Goldstein SR, Neven P, Zhou L, Taylor YL, Ciaccia AV, Plouffe L.: Raloxifene effect on frequency of surgery for pelvic floor relaxation. Obstet Gynecol 2001; 98: 91-96.
  • 8) Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A.: Pelvic organ prolapse in the Women’s Health Initiative: gravity and gravidity. Am J Obstet Gynecol 2002; 186:1160+1166.
  • 9) Mant J, Painter R, Vessey M.: Epidemiology of genital prolapse: observations from the Oxford family planning association study. BJOG 1997; 104: 579- 585. 10) Moalli PA, Jones Ivy S, Meyn LA, Zyczynski HM. Risk factors associated with pelvic floor disorders in women undergoing surgical repair. Obstet Gynecol 2003; 101: 869-874.
  • 11) Luber KM, Boero S, Choe JY.: The demographics of pelvic floor disorders: current observations and future projections. Am J Obstet Gynecol 2001; 184:1496- 1501.
  • 12) Sampselle CM, Wyman JF, Thomas KK, Newman DK, Gray M, Dougherty M, et al.: Continence for women: evaluation of AWHONN's third research utilization project. Association of Women's Health Obstetric and Neonatal Nurses. J Obstet Gynecol Neonatal Nurs 2000; 29:9-17.
  • 13) American College of Obstetricians and Gynecologists. Pelvic organ prolapse. ACOG Technical Bulletin 214. Washington, DC: ACOG. 1995.
  • 14) Bump RC, Mattiasson A, Bo K.: The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 1996; 175:10-17.
  • 15) Blakeman A, Hilton A, Bulmer JN.: Mapping oestrogen and progesterone receptors throughout the female lower urinary tract. Abstracts from the 26th Annual Meeting of the International Continence Society. Neurologic Urodynamics 1996; 15:324-325.
  • 16) Cicinelli E, Einer-Jensen N, Galantino P, Pinto V, Barba B, Tartangni M.: Model of counter-current transfer from vagina to urethra in postmenopausal women.Human Reproduction 2001; 16:2496-2500.
  • 17) Robinson D, Cardozo L.: The role of estrogens in female lower urinary tract dysfunction. Urology 2003; 62:45-51.
  • 18) Vardy M, Lindsay R, Scotti R, Mikhail M, Richart R, Nieves J, et al.: Short-term urogenital effects of raloxifene, tamoxifen, and estrogen. Am J Obstet Gynecol 2003; 189:81-88.
  • 19) Kim SW, Kim NN, Jeong SJ, Munarriz R, Goldstein I, Traish AM.: Modulation of rat vaginal blood flow and estrogen receptor by estradiol. J Urol 2004; 172:1538-1543.
  • 20) Pessina, MA; Hoyt, RF; Goldstein, I; Traish, AM.: Differential effects of estradiol, progesterone, and testosterone on vaginal structural integrity. Endocrinol.ogy 2006;147:161-169.
  • 21) Christ GJ, Hodges S.: Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol 2006; 147 : 41-55.
  • 22) Daneshgari F, Moore C.: Diabetic uropathy. Semin Nephrol 2006; 26:182-185.
  • 23) Boreham MK, Wai CY, Miller RT, Schaffer JI, Word RA.: Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol 2002; 187:56-63.
  • 24) Lin SY, Tee YT, Ng SC, Chang H, Lin PP, Chen GD.: Changes in the extracellular matrix in the anterior vagina of women with or without prolapse. Int Urogynecol J Pelvic Floor Dysfunct 2006; 18:43-48.
  • 25) Wong MY, Harmanli OH, Agar M, Dandolu V, Grody MHT.: Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence. Am J Obstet Gynecol 2003; 189:1597-1600.
  • 26) Norton PA.: Pelvic floor disorders: The role of fascia and ligaments. Clin Obstet Gynecol 1993; 36:926- 938.
  • 27) Lubowski DZ, Swash M, Nicholls RJ, Henry MM.: Increase in pudendal nerve terminal motor latency with defaecation straining. Br J Surg 1988; 75:1095- 1097.
  • 28) Sapsford RR, Hodges PW.: Contraction of the pelvic floor muscles during abdominal maneuvers. Arch Phys Med Rehabil 2001; 82:1081-1088.
  • 29) Moalli PA, Ivy SJ, Meyn LA, Zyczynski HM.: Risk factors associated with pelvic floor disorders in women undergoing surgical repair. Obstet Gynecol 2003;101:869-874.
  • 30) Lawrence JM, Charles WN, Emily SL, Karl ML, In-Lu AL.: Pelvic Floor Disorders, Diabetes, and Obesity in Women. Diabetes Care 2007; 30:2536-2541.
There are 29 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Hakan Coksuer This is me

Berna Haliloğlu This is me

Mutlu Ercan This is me

Mesut Kose This is me

Uğur Keskin This is me

İbrahim Alanbay This is me

Emre Karaşahin This is me

Canan Kabaca This is me

Ateş Karateke This is me

Publication Date April 1, 2011
Published in Issue Year 2011 Volume: 3 Issue: 1

Cite

Vancouver Coksuer H, Haliloğlu B, Ercan M, Kose M, Keskin U, Alanbay İ, Karaşahin E, Kabaca C, Karateke A. The Effects of Diabetes Mellitus and Obesity to Pelvic Organ Prolapse in Postmenopausal Women. Maltepe tıp derg. 2011;3(1):21-7.