A Natural Power to Fight Cancer: Anti-Cancer Effects of Hispolone in Medicinal Mushrooms

Abstract

Cancer is the second leading cause of death in our country and is an important public health problem worldwide. In the past few years, natural compounds, especially those derived from food, have been identified as many anti-cancer drugs or supplements. But very few of them are either in further clinical trials or already approved for therapeutic use. Hispolon is a phenolic compound from the styrylpyrrone group, which is found in medicinal mushrooms, which are traditionally used in the treatment of many diseases, including cancer treatment. Our aim in this review is to explain the anti-cancer effects of the hispolon compound and the possible mechanisms of these effects. It has been reported that hispolon, a bioactive natural compound, has anti-cancer effects through mechanisms such as cell cycle arrest, apoptotic, anti-proliferative, tumor regression, and anti-metastatic. Studies on Hispolone are new and its mechanisms and toxicity are not fully understood. In addition, almost all studies are at the cellular level. More clinical studies are needed for the use of Hispolone as an anti-cancer drug or as an alternative supplement.

Keywords

• Medicinal Mushrooms
• Hispolon
• Anti-cancer
• Mechanisms

Kanserle Savaşta Doğal bir Güç: Tıbbi Mantarlardaki Hispolonun Anti-Kanser Etkileri

Abstract

Kanser ülkemizde ölüm nedenleri arasında ikinci sırada yer almaktadır ve dünya çapında önemli bir halk sağlığı sorunudur. Geçtiğimiz birkaç yıl içinde, özellikle besinlerden elde edilen doğal bileşikler birçok kanser önleyici ilaç ya da takviye olarak tanımlanmıştır. Fakat bunların çok azı ya ileri klinik deneylerdedir ya da terapötik kullanım için hâlihazırda onaylanmıştır. Hispolon, geleneksel olarak kanser tedavisi dâhil birçok hastalık tedavisinde kullanılan tıbbi mantar türlerinde karşımıza çıkan stirilpiron grubundan fenolik bir bileşiktir. Bu derlemede amacımız, hispolon bileşiğinin anti-kanser etkilerini ve bu etkilerin olası mekanizmalarını açıklamaktır. Biyoaktif doğal bileşik olan hispolonun, hücre döngüsünü durdurma, apoptotik, anti-proliferatif, tümör gerilemesi, anti-metastatik gibi mekanizmalar yoluyla anti-kanser etki gösterdiği bildirilmiştir. Hispolonla ilgili çalışmalar daha yeni ve mekanizmaları, toksisitesi tam olarak anlaşılmış değildir. Ek olarak, nerdeyse tüm çalışmalar hücre düzeyindedir. Hispolonun, anti-kanser bir ilaç olarak ya da alternatif bir takviye olarak kullanımı için daha fazla klinik çalışmaya ihtiyaç vardır.

Keywords

• Tıbbi Mantarlar
• Hispolon
• Anti-kanser
• Mekanizmalar

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