Havasal Aspergillus İzolatlarının Antifungal Duyarlılıklarının Belirlenmesi

Abstract

Çalışmamız ile bina dışı havada bulunan Aspergillus genusu üyelerinin yoğunlukları ve klinik antifungallere karşı duyarlılık/dirençlilik durumları belirlenmeye çalışılmıştır. Bu amaçla, Manisa il merkezinde belirlenen 5 istasyondan gravimetrik yöntemle hava örneklemesi yapılmıştır. Çalışma kapsamında toplam 1877 mikrofungus kolonisi sayılmış ve 102 Aspergillus sp. izolatı elde edilmiştir. Bu izolatların identifikasyonu sonucu altı farklı tür tespit edilmiştir. Antifungal duyarlılık testleri için klinikte sıklıkla tercih edilen amfoterisin B, flukonazol ve itrokonazol kullanılmıştır. İncelenen mikrofungus izolatlarının her üç antifungalin tedavi dozlarına karşı değişik oranlarda dirençlilik geliştirdiği tespit edilmiştir.

Keywords

• Aspergillus sp.
• Antifungal duyarlılık
• Havasal mikrofungus
• Manisa

Determination of Antifungal Susceptibility of Aerial Aspergillus Isolates

Abstract

Our study aimed to determine the density, and clinical antifungal susceptibility/resistance of Aspergillus genus members in outdoor air. For this purpose, air sampling was performed by gravimetric method from 5 stations determined in Manisa city center. Within the scope of the study, a total of 1877 microfungus colonies were counted and 102 Aspergillus sp. isolates were obtained. As a result of the identification of these isolates, six different species were identified. Amphotericin B, fluconazole and itroconazole, which are frequently preferred in clinics, were used for antifungal susceptibility tests. It was determined that the examined microfungus isolates developed resistance at different rates to the treatment doses of all three antifungals.

Keywords

• Aspergillus sp.
• Antifungal susceptibility
• Airborne microfungi
• Manisa

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