Research Article
BibTex RIS Cite

Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması

Year 2018, Volume: 30 Issue: 2, 189 - 194, 30.06.2018
https://doi.org/10.7240/marufbd.410268

Abstract

Bir mantar (mikobiyont) ve bir
yeşil algin ve/veya siyanobakterinin (fotobiyont) bir araya gelmesiyle oluşan likenler;
bu ortak yaşam sonucunda kendilerine özgü sekonder metabolitler üretirler.
Yapılan araştırmalarda likenlerin bu
sekonder metabolitler sayesinde çeşitli biyolojik aktivitelere ve antibakteriyel
etkilere sahip oldukları bildirilmektedir. 
Bu çalışmada dalsı liken Pseudevernia furfuracea
(L.) Zopf türüne
ait örneklerden elde edilen aseton ekstrelerinin ATCC 29212 Enterococcus faecalis, ATCC 25923 Staphylococcus aureus, CECT 4122 Pseudomonas aeruginosa, ATCC 25922 Escherichia coli suşları üzerindeki
antibakteriyel aktiviteleri disk difüzyon yöntemi ile araştırılmıştır. Ayrıca
aynı liken ekstrelerinin antioksidan kapasiteleri CUPRAC metodu kullanılarak
değerlendirilmiştir.
Elde edilen sonuçlara göre, P. furfuracea aseton ekstreleri Gram negatif bakterilere karşı
etkisiz olurken Gram pozitif bakterilerin gelişimini inhibe etmiştir. Antioksidan
olarak ise
9,653 ± 0,102 µg TE/gr değerinde hesaplanan iyi düzeyde aktivite göstermiştir. P. furfuracea liken türünün farmakoloji
alanında doğal kaynak olarak kullanılabileceği öngörülmektedir.

References

  • Referans1 Shibata, S., Ukıta, T., Tamura, T., & Miura, Y. (1948). Relation between chemical constitutions and antibacterial effects of usnic acid and its derivatives. The Japanese Medical Journal, 1(2), 152-155.
  • Referans2 Nash III TH. (1996). Lichen Biology, Cambridge: Cambridge University Press.
  • Referans3 Dayan, F. E., & Romagni, J. G. (2001). Lichens as a potential source of pesticides. Pesticide Outlook, 12(6), 229-232.
  • Referans4 Harmala, P., Hiltunen, R., Oksman-Caldentey, K. M., Laakso, T., & Kauppinen, V. (1992). Isolation and in vitro cultivation of lichen algae and their antimicrobial properties. Fitoterapia, 63, 217-225.
  • Referans5 Lawrey, J. D. (1986). Biological role of lichen substances. Bryologist, 111-122.
  • Referans6 Gücin, E., Dülger, B. Aslan, A. (1997). Pseudoevernia furfuracea (L.) Zopf. Likeninin Antimikrobiyal Aktivitesi, Ekoloji-Çevre Dergisi, 7(25): 22-24.
  • Referans7 Öztürk, Ş..Güvenç, Ş., (1995). Farklı Bölgelerden Toplanan Liken Örneği Pseudevemia furfuracea (L.) Zopf. var. furfuracea' nın Antimicrobiyal Etkilerinin Karşılaştırılması. Tr. J. of Botany 19, 145-148.
  • Referans8 Gücin, E., Dülger, B. Aslan, A. (1997). Pseudoevernia furfuracea (L.) Zopf. Likeninin Antimikrobiyal Aktivitesi, Ekoloji-Çevre Dergisi, 7(25): 22-24.
  • Referans9 Velioglu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998). Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. Journal of agricultural and food chemistry, 46(10), 4113-4117.
  • Referans10 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans11 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans12 Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M. C., ... & Pommier, Y. (1997). Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. Journal of medicinal chemistry, 40(6), 942-951.
  • Referans13 Demleitner, S., Kraus, J., & Franz, G. (1992). Synthesis and antitumour activity of derivatives of curdlan and lichenan branched at C-6. Carbohydrate research, 226(2), 239-246.
  • Referans14 Süleyman, H., Yildirim, D., Aslan, A., Göçer, F., Gepdiremen, A., & Güvenalp, Z. (2002). An Investigation of the Antiinflammatory Effects of an Extract from Cladonia rangiformis HOFFM. Biological and Pharmaceutical Bulletin, 25(1), 10-13.
  • Referans15 Huneck, S. (1999). The significance of lichens and their metabolites. Naturwissenschaften, 86(12), 559-570.
  • Referans16 Culberson W., L. (1970). Chemosystematics and ecology of lichens-forming fungi. Ann Rev Ecol Sys, 1:153-70.
  • Referans17 Lawery, J.D. (1989). Lichen secondary Compounds Evidence for a Correspondence Between Antiherbivore and Antimicrobial Function. Bryologist, 92 (3),326-328.
  • Referans18 Machlin, L. J., & Bendich, A. (1987). Free radical tissue damage: protective role of antioxidant nutrients. The FASEB Journal, 1(6), 441-445.
  • Referans19 Fang, Y. Z., Sheng, Y., WU, G. (2002). Free Radicals, Antioxidants, and Nutrition, Nutrition. Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China. Oct;18, 872-879.
  • Referans20 Halliwell, B., & Gutteridge, J. M. (2015). Free radicals in biology and medicine. Oxford University Press, USA.
  • Referans21 Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84.
  • Referans22 Sarikurkcu, C., Kocak, M. S., Calapoglu, M., Ocal, C., & Tepe, B. (2016). Biological and phytochemical evaluation: Pseudevernia furfuracea as an alternative multifunctional agent. Journal of Functional Foods, 24, 11-17.
  • Referans23 Joulain, D., & Tabacchi, R. (2009). Lichen extracts as raw materials in perfumery. Part 2: treemoss. Flavour and Fragrance Journal, 24(3), 105-116.
  • Referans24 Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of agricultural and food chemistry, 52(26), 7970-7981.
  • Referans25 Osmanağaoğlu, Ö., Yıldız, A., & Saçılık, S. (2000). Türkiye’deki farklı bölgelerden izole edilen likenlerin antimikrobiyal aktiviteleri. Türk Mikrobiyol. Cem. Derg, 30, 17-19.
  • Referans26 Güvenç, A., Akkol, E. K., Süntar, İ., Keleş, H., Yıldız, S., & Çalış, İ. (2012). Biological activities of Pseudevernia furfuracea (L.) Zopf extracts and isolation of the active compounds. Journal of ethnopharmacology, 144(3), 726-734.
  • Referans27 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans28 Sarikurkcu, C., Kocak, M. S., Calapoglu, M., Ocal, C., & Tepe, B. (2016). Biological and phytochemical evaluation: Pseudevernia furfuracea as an alternative multifunctional agent. Journal of Functional Foods, 24, 11-17.
  • Referans29 Özyiğitoğlu, G. Ç., Açıkgöz, B., & Sesal, C. (2016). Lichen secondary metabolites: Synthesis pathways and biological activities. Acta Biologica Turcica, 29(4), 150-163.
Year 2018, Volume: 30 Issue: 2, 189 - 194, 30.06.2018
https://doi.org/10.7240/marufbd.410268

Abstract

References

  • Referans1 Shibata, S., Ukıta, T., Tamura, T., & Miura, Y. (1948). Relation between chemical constitutions and antibacterial effects of usnic acid and its derivatives. The Japanese Medical Journal, 1(2), 152-155.
  • Referans2 Nash III TH. (1996). Lichen Biology, Cambridge: Cambridge University Press.
  • Referans3 Dayan, F. E., & Romagni, J. G. (2001). Lichens as a potential source of pesticides. Pesticide Outlook, 12(6), 229-232.
  • Referans4 Harmala, P., Hiltunen, R., Oksman-Caldentey, K. M., Laakso, T., & Kauppinen, V. (1992). Isolation and in vitro cultivation of lichen algae and their antimicrobial properties. Fitoterapia, 63, 217-225.
  • Referans5 Lawrey, J. D. (1986). Biological role of lichen substances. Bryologist, 111-122.
  • Referans6 Gücin, E., Dülger, B. Aslan, A. (1997). Pseudoevernia furfuracea (L.) Zopf. Likeninin Antimikrobiyal Aktivitesi, Ekoloji-Çevre Dergisi, 7(25): 22-24.
  • Referans7 Öztürk, Ş..Güvenç, Ş., (1995). Farklı Bölgelerden Toplanan Liken Örneği Pseudevemia furfuracea (L.) Zopf. var. furfuracea' nın Antimicrobiyal Etkilerinin Karşılaştırılması. Tr. J. of Botany 19, 145-148.
  • Referans8 Gücin, E., Dülger, B. Aslan, A. (1997). Pseudoevernia furfuracea (L.) Zopf. Likeninin Antimikrobiyal Aktivitesi, Ekoloji-Çevre Dergisi, 7(25): 22-24.
  • Referans9 Velioglu, Y. S., Mazza, G., Gao, L., & Oomah, B. D. (1998). Antioxidant activity and total phenolics in selected fruits, vegetables, and grain products. Journal of agricultural and food chemistry, 46(10), 4113-4117.
  • Referans10 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans11 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans12 Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M. C., ... & Pommier, Y. (1997). Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching. Journal of medicinal chemistry, 40(6), 942-951.
  • Referans13 Demleitner, S., Kraus, J., & Franz, G. (1992). Synthesis and antitumour activity of derivatives of curdlan and lichenan branched at C-6. Carbohydrate research, 226(2), 239-246.
  • Referans14 Süleyman, H., Yildirim, D., Aslan, A., Göçer, F., Gepdiremen, A., & Güvenalp, Z. (2002). An Investigation of the Antiinflammatory Effects of an Extract from Cladonia rangiformis HOFFM. Biological and Pharmaceutical Bulletin, 25(1), 10-13.
  • Referans15 Huneck, S. (1999). The significance of lichens and their metabolites. Naturwissenschaften, 86(12), 559-570.
  • Referans16 Culberson W., L. (1970). Chemosystematics and ecology of lichens-forming fungi. Ann Rev Ecol Sys, 1:153-70.
  • Referans17 Lawery, J.D. (1989). Lichen secondary Compounds Evidence for a Correspondence Between Antiherbivore and Antimicrobial Function. Bryologist, 92 (3),326-328.
  • Referans18 Machlin, L. J., & Bendich, A. (1987). Free radical tissue damage: protective role of antioxidant nutrients. The FASEB Journal, 1(6), 441-445.
  • Referans19 Fang, Y. Z., Sheng, Y., WU, G. (2002). Free Radicals, Antioxidants, and Nutrition, Nutrition. Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China. Oct;18, 872-879.
  • Referans20 Halliwell, B., & Gutteridge, J. M. (2015). Free radicals in biology and medicine. Oxford University Press, USA.
  • Referans21 Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84.
  • Referans22 Sarikurkcu, C., Kocak, M. S., Calapoglu, M., Ocal, C., & Tepe, B. (2016). Biological and phytochemical evaluation: Pseudevernia furfuracea as an alternative multifunctional agent. Journal of Functional Foods, 24, 11-17.
  • Referans23 Joulain, D., & Tabacchi, R. (2009). Lichen extracts as raw materials in perfumery. Part 2: treemoss. Flavour and Fragrance Journal, 24(3), 105-116.
  • Referans24 Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of agricultural and food chemistry, 52(26), 7970-7981.
  • Referans25 Osmanağaoğlu, Ö., Yıldız, A., & Saçılık, S. (2000). Türkiye’deki farklı bölgelerden izole edilen likenlerin antimikrobiyal aktiviteleri. Türk Mikrobiyol. Cem. Derg, 30, 17-19.
  • Referans26 Güvenç, A., Akkol, E. K., Süntar, İ., Keleş, H., Yıldız, S., & Çalış, İ. (2012). Biological activities of Pseudevernia furfuracea (L.) Zopf extracts and isolation of the active compounds. Journal of ethnopharmacology, 144(3), 726-734.
  • Referans27 Mitrovic, T., Stamenkovic, S., Cvetkovic, V., Radulovic, N., Mladenovic, M., Stankovic, M., ... & Comic, L. (2014). Platismatia glaucia and Pseudevernia furfuracea lichens as sources of antioxidant, antimicrobial and antibiofilm agents. EXCLI journal, 13, 938.
  • Referans28 Sarikurkcu, C., Kocak, M. S., Calapoglu, M., Ocal, C., & Tepe, B. (2016). Biological and phytochemical evaluation: Pseudevernia furfuracea as an alternative multifunctional agent. Journal of Functional Foods, 24, 11-17.
  • Referans29 Özyiğitoğlu, G. Ç., Açıkgöz, B., & Sesal, C. (2016). Lichen secondary metabolites: Synthesis pathways and biological activities. Acta Biologica Turcica, 29(4), 150-163.
There are 29 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Research Articles
Authors

Sinem Gültekin 0000-0001-7008-0489

Gülşah Özyiğitoğlu This is me 0000-0002-3549-2872

Publication Date June 30, 2018
Acceptance Date June 28, 2018
Published in Issue Year 2018 Volume: 30 Issue: 2

Cite

APA Gültekin, S., & Özyiğitoğlu, G. (2018). Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması. Marmara Fen Bilimleri Dergisi, 30(2), 189-194. https://doi.org/10.7240/marufbd.410268
AMA Gültekin S, Özyiğitoğlu G. Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması. MAJPAS. June 2018;30(2):189-194. doi:10.7240/marufbd.410268
Chicago Gültekin, Sinem, and Gülşah Özyiğitoğlu. “Pseudevernia Furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması”. Marmara Fen Bilimleri Dergisi 30, no. 2 (June 2018): 189-94. https://doi.org/10.7240/marufbd.410268.
EndNote Gültekin S, Özyiğitoğlu G (June 1, 2018) Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması. Marmara Fen Bilimleri Dergisi 30 2 189–194.
IEEE S. Gültekin and G. Özyiğitoğlu, “Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması”, MAJPAS, vol. 30, no. 2, pp. 189–194, 2018, doi: 10.7240/marufbd.410268.
ISNAD Gültekin, Sinem - Özyiğitoğlu, Gülşah. “Pseudevernia Furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması”. Marmara Fen Bilimleri Dergisi 30/2 (June 2018), 189-194. https://doi.org/10.7240/marufbd.410268.
JAMA Gültekin S, Özyiğitoğlu G. Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması. MAJPAS. 2018;30:189–194.
MLA Gültekin, Sinem and Gülşah Özyiğitoğlu. “Pseudevernia Furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması”. Marmara Fen Bilimleri Dergisi, vol. 30, no. 2, 2018, pp. 189-94, doi:10.7240/marufbd.410268.
Vancouver Gültekin S, Özyiğitoğlu G. Pseudevernia furfuracea (L.) Zopf Liken Türünün Antibakteriyel Aktivitesi Ve Antioksidan Kapasitesinin Araştırılması. MAJPAS. 2018;30(2):189-94.

Marmara Journal of Pure and Applied Sciences

e-ISSN : 2146-5150