Parvovirus-induced autoimmune hepatitis: First case in the literature

Year 2022, , 376 - 378, 31.10.2022

Arda Yavuz Ayse Nur Toksoz Yıldırım , Feruze Yılmaz Enc Ilyas Tuncer

https://doi.org/10.5472/marumj.1195421

Abstract

Parvovirus B19 infection is usually self-limiting in immunocompetent individuals. Twenty-five percent of infected individuals are
completely asymptomatic during infection, with 50% of them presenting flu-like symptoms and the remaining patients presenting
erythema infectiosum, arthralgia, or arthritis. More rarely, transient aplastic crisis is seen in individuals with chronic haemolytic
disorders. Chronic pure red cell aplasia and aplastic anaemia may also be observed in immunocompromised patients. There is
sufficient evidence in the literature suggesting that B19 infections can also cause a spectrum of liver diseases, ranging from elevated
transaminase levels to acute hepatitis, fulminant liver failure, and even chronic hepatitis. This case report discusses a patient with
acute parvovirus infection and newly diagnosed autoimmune hepatitis (AIH) and the role of this viral infection in the disease.

Keywords

Parvovirus, autoimmune hepatitis, acute liver injury, pancytopenia

References

• Bihari C, Rastogi A, Saxena P et al. Parvovirus b19 associated hepatitis. Hepat Res Treat 2013;2013:472027.
• Krygier DS, Steinbrecher UP, Petric M et al. Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation. World J Gastroenterol 2009; 15(32): 4067–9.
• Kerr JR, Boyd N. Autoantibodies following parvovirus B19 infection. J Infect 1996;32:41–7.