Diagnostic utility of the systemic immune-inflammatory index in preterm neonates with late-onset sepsis

Year 2023, , 319 - 325, 29.09.2023

Gonca Vardar , Eren Özek

https://doi.org/10.5472/marumj.1367904

Abstract

Objective: To assess if systemic immune-inflammatory index (SII) has a diagnostic role for late-onset sepsis (LOS) in premature
neonates.
Patients and Methods: A single-center retrospective observational study including preterm infants with culture-proven LOS and
controls was conducted between January 2017 and December 2022. SII was derived using complete blood count values acquired at the
beginning of and three to five days before LOS. SII was compared between the LOS group and controls.
Results: A total of 144 infants were included in the study. The SII values of the LOS group were found to be significantly increased in
comparison to the control group [376.74 (11.11 – 15170) vs. 235.24 (46.83 – 1214.38) (median, min-max), P =0.018]. The SII values
significantly increased when pre-sepsis and LOS values were compared [200.6 (0 – 1295.78) vs. 328.28 (0 – 14678, P<0.001]. As
determined using the receiver operating characteristic analysis, the area under the curve for SII was 0.621 (44.4% sensitivity, 83.3%
specificity, 72.7% positive predictive value, and 60% negative predictive value) for predicting LOS.
Conclusion: Although, further research is required, SII may be used with other biomarkers to identify LOS in preterm infants and may
constitute a readily accessible additional diagnostic parameter.

Keywords

Late-onset sepsis, Systemic immune-inflammatory index, Neonate, Biomarker

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