Progressive encephalopathy in a patient with diabetes mellitus: A case report and review of JCV-related neurological manifestations

Abstract

We present a case of a 66-year-old female patient with partially compromised immunity due to diabetes mellitus, exhibiting progressive encephalopathy characterized by balance issues, cognitive decline, and hallucinations. Magnetic resonance imaging (MRI) revealed widespread cerebral and cerebellar atrophy, and John Cunningham virus (JCV) – DNA was detected in the cerebrospinal fluid. This case highlights JCV encephalopathy as a potential diagnosis even in patients with partially weakened immune systems, expanding the recognized spectrum of JCV-associated neurological conditions beyond progressive multifocal leukoencephalopathy.

Keywords

• JCV encephalopathy
• Progressive encephalopathy
• Cerebral atrophy

References

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