Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis

S. Arbak

EN

Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis

Abstract

Studies have shown that prostaglandin E2 (PG E2) can prevent liver necrosis due to several agents. Dimethyl sulfoxide (DMSO) is also known with its cytoprotective efficiency. To determine the degree of cytoprotective effectivenesses of these two agents, 20 female rats were divided into 5 groups.

Livers of rats treated only with carbon tetrachloride showed severe necrosis. In groups pretreated with prostaglandin E2 and dimethyl sulfoxide, degree of necrosis was very low. Especially prostaglandin E2 could perform this cytoprotection very well.

It is concluded that these two cytoprotective agents could prevent carbon tetrachloride-induced liver cell necrosis in the rats at different degrees.

Keywords

Carbon tetrachloride,prostaglandin E2,dimethyl sulfoxide,cytoprotection

References

Robert A. et al. Cytoprotection by prostaglandins. Gastroenterol 1979; 77: 761-767.

Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

S. Arbak This is me
Türkiye

Publication Date

December 1, 1991

Submission Date

October 10, 2016

Acceptance Date

October 1, 1991

Published in Issue

Year 1991 Volume: 4 Number: 4

IZ

https://izlik.org/JA33PU48PC

Cite

RIS / Bibtex

APA

Arbak, S. (1991). Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Medical Journal, 4(4), 141-148. https://izlik.org/JA33PU48PC

AMA

1.Arbak S. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J. 1991;4(4):141-148. https://izlik.org/JA33PU48PC

Chicago

Arbak, S. 1991. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal 4 (4): 141-48. https://izlik.org/JA33PU48PC.

EndNote

Arbak S (December 1, 1991) Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Medical Journal 4 4 141–148.

IEEE

[1]S. Arbak, “Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis”, Marmara Med J, vol. 4, no. 4, pp. 141–148, Dec. 1991, [Online]. Available: https://izlik.org/JA33PU48PC

ISNAD

Arbak, S. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal 4/4 (December 1, 1991): 141-148. https://izlik.org/JA33PU48PC.

JAMA

1.Arbak S. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J. 1991;4:141–148.

MLA

Arbak, S. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal, vol. 4, no. 4, Dec. 1991, pp. 141-8, https://izlik.org/JA33PU48PC.

Vancouver

1.S. Arbak. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J [Internet]. 1991 Dec. 1;4(4):141-8. Available from: https://izlik.org/JA33PU48PC