Research Article
Ultrastructural examination of the morphological changes in the rat liver following choleduct ligation
Abstract
To investigate the effects of common bile duct ligation in rat liver, 20 female Wistar Albinor rats were divided into 1 control and 4 experimental groups in which common bile ducts were ligated successively for 1, 2, 3 and 4 weeks.
Electronmicroscopical investigation showed hepatocyte degeneration and fibrosis. We evaluated those morphological changes as follows : invaginations at hepatocyte nuclei, swollen mitochondria, fingerprint formation of hypertrophied granular endoplasmic reticulum within the hepatocyte cytoplasm, dense collagenous fibers at both the Space of Diss6 and portal triad. We concluded as those ultrastructural changes showed an augmentation with increasing ligation period.
References
- Qrossman H. Seed W. Congenital hepatic fibrosis, bile duct dilatation and renal Jesion resembling medullary sponge kidney. Radiology 1966; 87: 49-54.
Year 1992,
Volume: 5 Issue: 1, 14 - 19, 01.01.1992
Abstract
References
- Qrossman H. Seed W. Congenital hepatic fibrosis, bile duct dilatation and renal Jesion resembling medullary sponge kidney. Radiology 1966; 87: 49-54.
There are 1 citations in total.
Details
| Subjects | Clinical Sciences |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 1, 1992 |
| IZ | https://izlik.org/JA75MG98ES |
| Published in Issue | Year 1992 Volume: 5 Issue: 1 |