2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells

G. Hergenç; K. Emerk

EN

2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells

Abstract

Glucose transport into human peripheral lymphocytes, rat lymphocytes, and rat thymocytes were investigated using 2-deoxyglucose (2-DOG) in the transport studies. Our results showed rat thymocytes to have a high affinity and a low affinity system for transporting 2-DOG with Km values of

0.11 mM and 7.14 mM respectively. Both of the systems were inhibited by phloretin (0.1 mM), a specific inhibitor of carrier mediated transport. Human peripheral lymphocytes and rat lymphoctes transported 2-DOG with Km values of 5.26 mM and 3.57 mM respectively. While insulin had no effect on this transport in thymocytes and lymphocytes, it inhibited the efflux of 2-DOG from the cells.

Keywords

2-DOG,uptake,lymphocytes,thymocytes,transport,insulin

References

Carruthers A. Facilitated diffusion of glucose. Physiol Reviews 1990:70:1135-1176.

Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

G. Hergenç This is me
Türkiye

K. Emerk This is me
Türkiye

Publication Date

January 1, 1996

Submission Date

November 11, 2016

Acceptance Date

October 1, 1995

Published in Issue

Year 1996 Volume: 9 Number: 1

IZ

https://izlik.org/JA98CY83LR

Cite

RIS / Bibtex

APA

Hergenç, G., & Emerk, K. (1996). 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Medical Journal, 9(1), 23-28. https://izlik.org/JA98CY83LR

AMA

1.Hergenç G, Emerk K. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J. 1996;9(1):23-28. https://izlik.org/JA98CY83LR

Chicago

Hergenç, G., and K. Emerk. 1996. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal 9 (1): 23-28. https://izlik.org/JA98CY83LR.

EndNote

Hergenç G, Emerk K (January 1, 1996) 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Medical Journal 9 1 23–28.

IEEE

[1]G. Hergenç and K. Emerk, “2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells”, Marmara Med J, vol. 9, no. 1, pp. 23–28, Jan. 1996, [Online]. Available: https://izlik.org/JA98CY83LR

ISNAD

Hergenç, G. - Emerk, K. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal 9/1 (January 1, 1996): 23-28. https://izlik.org/JA98CY83LR.

JAMA

1.Hergenç G, Emerk K. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J. 1996;9:23–28.

MLA

Hergenç, G., and K. Emerk. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal, vol. 9, no. 1, Jan. 1996, pp. 23-28, https://izlik.org/JA98CY83LR.

Vancouver

1.G. Hergenç, K. Emerk. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J [Internet]. 1996 Jan. 1;9(1):23-8. Available from: https://izlik.org/JA98CY83LR