HEPATOCELLULAR CHILDHOOD CARCINOMA WITH A PRESENTATION OF TWO CASES

Abstract

Hepatocellular carcinoma is relatively infrequent in childhood. Hepatocellular carcinoma in younger than age 15 is also associated with hepatitis B virus as seen in adult population.
Here two HCC cases due to hepatitis B have been presented.
Key Words: Hepatocellular Carcinoma
Hepatitis B, Childhood

References

1. Greenberg M, Filler MR. hepatic tumours. In: Pizzo AP, Poplack GD, eds. Principles and practice of pediatric oncology, Philadelphia: JB Lippincott Com 1997; 27; 717-732.
2. Exelby P, Filler R, Grosfeld JL. Liver tumours in children in particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Survery system - 1974. J Pediatr Surg 1975; 10: 329-337.
3. Hepatocellular childhood carcinoma
4. Newman RD. Malignant liver tumours in childhood. Semin Pediatr Surg 1992; 1: 145- 151.
5. Fossati Bellani F, Massimino M. Liver tumours in childhood: epidemiology and clinics. J Surg Oncol 1993; 3: (Suppl) 119-121.
6. Hoy CC, Silverman AA, Alagille D. Pediatric clinical gastroenteroloogy. Mosby-year Book Inc. 1995: 877-890.
7. Popper li, Gerber MA. Thung SI"1. The relation of hepatocellular carcinoma to infection with hepatitis B and related viruses in man and animals. Hepatology 1982; 2: ls-9s.
8. Beasley RP. Hepatitis B virus as the etiologic agent in hepatocellular carcinoma: Epidemiologic considerations. Hepatology 1982; 2: 2ls-26s.

9. Larouze B, London WT, Saimot G, et al. Host responses to hepatitis B infection in patients with primary hepatic carcinoma and their families: A case-control study in Senegal, West Africa. Lancet 1976; 2: 534-538.
10. Chang HM, Chen SD, Hsu CH, et al. Maternal Transmission of hepatitis B virus in childhood HCC. Cancer 1989; 64: 2377-2380.
11. Hadziyannis SJ, Lieberman HM, Karvountzis GG, et al. Analysis of liver disease, nuclear HbeAg, viral replication and hepatitis B virus DNA in liver and serum of HbeAg versus anti- Hbe pozitive carriers of hepatitis B virus. Hepatology1983; 3: 656-662.
12. I. Chen DS, Hoyer BH, Nelson J, et al. Detection and properties of hepatitis B virus DNA liver
13. tissues from patients with hepatocellular carcinoma. Hepatolog 1982; 2: 42s-46s.
14. Moore D, Pazdur R. Systemic therapies for unresectable primary hepatic tumours. J Surg Oncol 1993; 3: (Suppl) 112-114.
15. Purves LR, MacNab M, Geddes EW, Behrson I. Serum alpha fetoprotein and primary liver cancer. Lancet 1968; 2: 921-922.
16. Moore IV5, Hesseling BP, Wessels G, Scheneider W.J. Hepatocellular carcinoma in children. Pediatr Surg Int 1997; 12: 266-270.
17. Weinberg AG, Finegold MJ. Primary hepatic tumours of childhood. Hum Pathol 1983; 14: 512-537.
18. Weinberg AG, Finegold MJ. Primary hepatic tumours in childhood. In: Finegold MJ, Bennington JL, eds. Pathology of neoplazia in children and adolescents. Philadelphia; Saunders, Philadelphia, 1986; pp 333-372.
19. Pazdur R, Bready B, CangirA. Pediatric hepatis tumours: clinical trials conducted in the United State. J Surg Oncol 1993; 3: (Suppl) 127-130.
20. Ringe B, Pichlmayr R, Wittekind C, Tusch Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. World J Surg 1991; 15: 270-285.
21. Suenaga M, Nakao A, Harada A, et al. Hepatic resection for hepatocellular carcinoma. World J Surg 1992; 16: 97-105.