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Combining radiotherapy with immunotherapy

Year 2015, Special Issue :1 Oncology, 40 - 44, 30.09.2015

Yavuz Anacak , Serra Kamer Fatma Sert

https://doi.org/10.5472/mmj.34632
https://izlik.org/JA89WH44YB

Abstract

It has long been known that radiation destroys the tumors
by killing cells. However, immunotherapy is developing
rapidly, combination of immunotherapy with chemotherapy
and radiotherapy seems to be a viable option. Preclinical
studies combining immunotherapy with radiotherapy
resulted in promising data, where manipulating immune
response enhances the effects of radiation. There are many
ways of immunotherapy-radiotherapy combination, and the
field is open for clinical research. This paper reviews the
current situation on this topic.
Keywords: Immunotherapy, Radiotherapy

Keywords

Immunotherapy Radiotherapy

References

  • 1. Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009;5:1262-70. doi: 10.1039/b911313b.
  • 2. Vatner RE, Cooper BT, Vanpouille-Box C, Demaria S, Formenti SC. Combinations of immunotherapy and radiation in cancer therapy. Front Oncol 2014;4:325. doi: 10.3389/fonc.2014.00325.
  • 3. Barker CA, Postow MA. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int J Radiat Oncol Biol Phys 2014;88:986-97. doi: 10.1016/j.ijrobp.2013.08.035.
  • 4. Shahabi V, Postow MA, Tuck D, Wolchok JD. Immunepriming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol 2015;38:90-7. doi : 10.1097/COC.0b013e3182868ec8.
  • 5. Sharon E, Polley MY, Bernstein MB, Ahmed M. Immunotherapy and radiation therapy: considerations for successfully combining radiation into the paradigm of immuno-oncology drug development. Radiat Res 2014;182:252-7. doi: 10.1667/RR13707.1.
  • 6. Kalbasi A, June CH, Haas N, Vapiwala N. Radiation and immunotherapy: a synergistic combination. J Clin Invest 2013;123:2756-63. doi: 10.1172/JCI69219.
  • 7. Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol 2012;2:88. doi: 10.3389/fonc.2012.00088.
  • 8. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94. doi:10.1038/nri749
  • 9. Ogden CA, deCathelineau A, Hoffmann PR, et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001;194:781-95. doi:10.1084/jem.194.6.781.
  • 10. Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013;105:256-65. doi:10.1093/jnci/djs629.
  • 11. Golden EB, Frances D, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology 2014;3:e28518. doi:10.4161/onci.28518.
  • 12. Gaugler MH, Squiban C, van der Meeren A, Bertho JM, Vandamme M, Mouthon MA. Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM- 1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 1997;72:201-9.
  • 13. Matsumura S, Wang B, Kawashima N, et al. Radiationinduced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008;181:3099-107.
  • 14. Rekers NH, Troost EG, Zegers CM, Germeraad WT, Dubois LJ, Lambin P. Stereotactic ablative body radiotherapy combined with immunotherapy: present status and future perspectives. Cancer Radiother 2014;18:391-5. doi:10.1016/j.canrad.2014.06.012.
  • 15. Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009; 10:718-26. doi: 10.1016/S1470-2045(09)70082-8.
  • 16. DewanMZ, GallowayAE, KawashimaN, et al. Fractionated but not single-dose radiotherapy induces an immune- mediated abscopal effect when combined with anti-CTLA-4antibody. Clin Cancer Res 2009; 15:5379–88. doi: 10.1158/1078-0432.
  • 17. Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925– 31. doi: 10.1056/NEJMoa1112824.
  • 18. Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation andipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1:365–72. doi: 10.1158/2326-6066
  • 19. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973;46:220–2.
  • 20. Rees GJ, Ross CM. Abscopal regression following radiotherapy for adenocarcinoma. Br J Radiol 1983; 56:63–6.
  • 21. Ohba K, Omagari K, Nakamura T, et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 1998;43:575–7.

Year 2015, Special Issue :1 Oncology, 40 - 44, 30.09.2015

Yavuz Anacak , Serra Kamer Fatma Sert

https://doi.org/10.5472/mmj.34632
https://izlik.org/JA89WH44YB

Abstract

References

  • 1. Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009;5:1262-70. doi: 10.1039/b911313b.
  • 2. Vatner RE, Cooper BT, Vanpouille-Box C, Demaria S, Formenti SC. Combinations of immunotherapy and radiation in cancer therapy. Front Oncol 2014;4:325. doi: 10.3389/fonc.2014.00325.
  • 3. Barker CA, Postow MA. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int J Radiat Oncol Biol Phys 2014;88:986-97. doi: 10.1016/j.ijrobp.2013.08.035.
  • 4. Shahabi V, Postow MA, Tuck D, Wolchok JD. Immunepriming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol 2015;38:90-7. doi : 10.1097/COC.0b013e3182868ec8.
  • 5. Sharon E, Polley MY, Bernstein MB, Ahmed M. Immunotherapy and radiation therapy: considerations for successfully combining radiation into the paradigm of immuno-oncology drug development. Radiat Res 2014;182:252-7. doi: 10.1667/RR13707.1.
  • 6. Kalbasi A, June CH, Haas N, Vapiwala N. Radiation and immunotherapy: a synergistic combination. J Clin Invest 2013;123:2756-63. doi: 10.1172/JCI69219.
  • 7. Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol 2012;2:88. doi: 10.3389/fonc.2012.00088.
  • 8. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94. doi:10.1038/nri749
  • 9. Ogden CA, deCathelineau A, Hoffmann PR, et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001;194:781-95. doi:10.1084/jem.194.6.781.
  • 10. Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013;105:256-65. doi:10.1093/jnci/djs629.
  • 11. Golden EB, Frances D, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology 2014;3:e28518. doi:10.4161/onci.28518.
  • 12. Gaugler MH, Squiban C, van der Meeren A, Bertho JM, Vandamme M, Mouthon MA. Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM- 1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 1997;72:201-9.
  • 13. Matsumura S, Wang B, Kawashima N, et al. Radiationinduced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008;181:3099-107.
  • 14. Rekers NH, Troost EG, Zegers CM, Germeraad WT, Dubois LJ, Lambin P. Stereotactic ablative body radiotherapy combined with immunotherapy: present status and future perspectives. Cancer Radiother 2014;18:391-5. doi:10.1016/j.canrad.2014.06.012.
  • 15. Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009; 10:718-26. doi: 10.1016/S1470-2045(09)70082-8.
  • 16. DewanMZ, GallowayAE, KawashimaN, et al. Fractionated but not single-dose radiotherapy induces an immune- mediated abscopal effect when combined with anti-CTLA-4antibody. Clin Cancer Res 2009; 15:5379–88. doi: 10.1158/1078-0432.
  • 17. Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925– 31. doi: 10.1056/NEJMoa1112824.
  • 18. Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation andipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1:365–72. doi: 10.1158/2326-6066
  • 19. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973;46:220–2.
  • 20. Rees GJ, Ross CM. Abscopal regression following radiotherapy for adenocarcinoma. Br J Radiol 1983; 56:63–6.
  • 21. Ohba K, Omagari K, Nakamura T, et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 1998;43:575–7.
There are 21 citations in total.

Details

Primary Language English
Authors

Yavuz Anacak

Serra Kamer This is me

Fatma Sert This is me

Publication Date September 30, 2015
DOI https://doi.org/10.5472/mmj.34632
IZ https://izlik.org/JA89WH44YB
Published in Issue Year 2015 Special Issue :1 Oncology

Cite

APA Anacak, Y., Kamer, S., & Sert, F. (2015). Combining radiotherapy with immunotherapy. Marmara Medical Journal, 28(1), 40-44. https://doi.org/10.5472/mmj.34632
AMA 1.Anacak Y, Kamer S, Sert F. Combining radiotherapy with immunotherapy. Marmara Med J. 2015;28(1):40-44. doi:10.5472/mmj.34632
Chicago Anacak, Yavuz, Serra Kamer, and Fatma Sert. 2015. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal 28 (1): 40-44. https://doi.org/10.5472/mmj.34632.
EndNote Anacak Y, Kamer S, Sert F (September 1, 2015) Combining radiotherapy with immunotherapy. Marmara Medical Journal 28 1 40–44.
IEEE [1]Y. Anacak, S. Kamer, and F. Sert, “Combining radiotherapy with immunotherapy”, Marmara Med J, vol. 28, no. 1, pp. 40–44, Sept. 2015, doi: 10.5472/mmj.34632.
ISNAD Anacak, Yavuz - Kamer, Serra - Sert, Fatma. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal 28/1 (September 1, 2015): 40-44. https://doi.org/10.5472/mmj.34632.
JAMA 1.Anacak Y, Kamer S, Sert F. Combining radiotherapy with immunotherapy. Marmara Med J. 2015;28:40–44.
MLA Anacak, Yavuz, et al. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal, vol. 28, no. 1, Sept. 2015, pp. 40-44, doi:10.5472/mmj.34632.
Vancouver 1.Yavuz Anacak, Serra Kamer, Fatma Sert. Combining radiotherapy with immunotherapy. Marmara Med J. 2015 Sep. 1;28(1):40-4. doi:10.5472/mmj.34632