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Combining radiotherapy with immunotherapy

Year 2015, , 40 - 44, 30.09.2015

Yavuz Anacak , Serra Kamer Fatma Sert

https://doi.org/10.5472/mmj.34632

Abstract

It has long been known that radiation destroys the tumors
by killing cells. However, immunotherapy is developing
rapidly, combination of immunotherapy with chemotherapy
and radiotherapy seems to be a viable option. Preclinical
studies combining immunotherapy with radiotherapy
resulted in promising data, where manipulating immune
response enhances the effects of radiation. There are many
ways of immunotherapy-radiotherapy combination, and the
field is open for clinical research. This paper reviews the
current situation on this topic.
Keywords: Immunotherapy, Radiotherapy

Keywords

Immunotherapy Radiotherapy

References

  • 1. Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009;5:1262-70. doi: 10.1039/b911313b.
  • 2. Vatner RE, Cooper BT, Vanpouille-Box C, Demaria S, Formenti SC. Combinations of immunotherapy and radiation in cancer therapy. Front Oncol 2014;4:325. doi: 10.3389/fonc.2014.00325.
  • 3. Barker CA, Postow MA. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int J Radiat Oncol Biol Phys 2014;88:986-97. doi: 10.1016/j.ijrobp.2013.08.035.
  • 4. Shahabi V, Postow MA, Tuck D, Wolchok JD. Immunepriming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol 2015;38:90-7. doi : 10.1097/COC.0b013e3182868ec8.
  • 5. Sharon E, Polley MY, Bernstein MB, Ahmed M. Immunotherapy and radiation therapy: considerations for successfully combining radiation into the paradigm of immuno-oncology drug development. Radiat Res 2014;182:252-7. doi: 10.1667/RR13707.1.
  • 6. Kalbasi A, June CH, Haas N, Vapiwala N. Radiation and immunotherapy: a synergistic combination. J Clin Invest 2013;123:2756-63. doi: 10.1172/JCI69219.
  • 7. Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol 2012;2:88. doi: 10.3389/fonc.2012.00088.
  • 8. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94. doi:10.1038/nri749
  • 9. Ogden CA, deCathelineau A, Hoffmann PR, et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001;194:781-95. doi:10.1084/jem.194.6.781.
  • 10. Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013;105:256-65. doi:10.1093/jnci/djs629.
  • 11. Golden EB, Frances D, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology 2014;3:e28518. doi:10.4161/onci.28518.
  • 12. Gaugler MH, Squiban C, van der Meeren A, Bertho JM, Vandamme M, Mouthon MA. Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM- 1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 1997;72:201-9.
  • 13. Matsumura S, Wang B, Kawashima N, et al. Radiationinduced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008;181:3099-107.
  • 14. Rekers NH, Troost EG, Zegers CM, Germeraad WT, Dubois LJ, Lambin P. Stereotactic ablative body radiotherapy combined with immunotherapy: present status and future perspectives. Cancer Radiother 2014;18:391-5. doi:10.1016/j.canrad.2014.06.012.
  • 15. Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009; 10:718-26. doi: 10.1016/S1470-2045(09)70082-8.
  • 16. DewanMZ, GallowayAE, KawashimaN, et al. Fractionated but not single-dose radiotherapy induces an immune- mediated abscopal effect when combined with anti-CTLA-4antibody. Clin Cancer Res 2009; 15:5379–88. doi: 10.1158/1078-0432.
  • 17. Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925– 31. doi: 10.1056/NEJMoa1112824.
  • 18. Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation andipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1:365–72. doi: 10.1158/2326-6066
  • 19. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973;46:220–2.
  • 20. Rees GJ, Ross CM. Abscopal regression following radiotherapy for adenocarcinoma. Br J Radiol 1983; 56:63–6.
  • 21. Ohba K, Omagari K, Nakamura T, et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 1998;43:575–7.

Year 2015, , 40 - 44, 30.09.2015

Yavuz Anacak , Serra Kamer Fatma Sert

https://doi.org/10.5472/mmj.34632

Abstract

References

  • 1. Kamrava M, Bernstein MB, Camphausen K, Hodge JW. Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? Mol Biosyst 2009;5:1262-70. doi: 10.1039/b911313b.
  • 2. Vatner RE, Cooper BT, Vanpouille-Box C, Demaria S, Formenti SC. Combinations of immunotherapy and radiation in cancer therapy. Front Oncol 2014;4:325. doi: 10.3389/fonc.2014.00325.
  • 3. Barker CA, Postow MA. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int J Radiat Oncol Biol Phys 2014;88:986-97. doi: 10.1016/j.ijrobp.2013.08.035.
  • 4. Shahabi V, Postow MA, Tuck D, Wolchok JD. Immunepriming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol 2015;38:90-7. doi : 10.1097/COC.0b013e3182868ec8.
  • 5. Sharon E, Polley MY, Bernstein MB, Ahmed M. Immunotherapy and radiation therapy: considerations for successfully combining radiation into the paradigm of immuno-oncology drug development. Radiat Res 2014;182:252-7. doi: 10.1667/RR13707.1.
  • 6. Kalbasi A, June CH, Haas N, Vapiwala N. Radiation and immunotherapy: a synergistic combination. J Clin Invest 2013;123:2756-63. doi: 10.1172/JCI69219.
  • 7. Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. The convergence of radiation and immunogenic cell death signaling pathways. Front Oncol 2012;2:88. doi: 10.3389/fonc.2012.00088.
  • 8. Srivastava P. Roles of heat-shock proteins in innate and adaptive immunity. Nat Rev Immunol 2002;2:185-94. doi:10.1038/nri749
  • 9. Ogden CA, deCathelineau A, Hoffmann PR, et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 2001;194:781-95. doi:10.1084/jem.194.6.781.
  • 10. Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 2013;105:256-65. doi:10.1093/jnci/djs629.
  • 11. Golden EB, Frances D, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology 2014;3:e28518. doi:10.4161/onci.28518.
  • 12. Gaugler MH, Squiban C, van der Meeren A, Bertho JM, Vandamme M, Mouthon MA. Late and persistent upregulation of intercellular adhesion molecule-1 (ICAM- 1) expression by ionizing radiation in human endothelial cells in vitro. Int J Radiat Biol 1997;72:201-9.
  • 13. Matsumura S, Wang B, Kawashima N, et al. Radiationinduced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008;181:3099-107.
  • 14. Rekers NH, Troost EG, Zegers CM, Germeraad WT, Dubois LJ, Lambin P. Stereotactic ablative body radiotherapy combined with immunotherapy: present status and future perspectives. Cancer Radiother 2014;18:391-5. doi:10.1016/j.canrad.2014.06.012.
  • 15. Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol 2009; 10:718-26. doi: 10.1016/S1470-2045(09)70082-8.
  • 16. DewanMZ, GallowayAE, KawashimaN, et al. Fractionated but not single-dose radiotherapy induces an immune- mediated abscopal effect when combined with anti-CTLA-4antibody. Clin Cancer Res 2009; 15:5379–88. doi: 10.1158/1078-0432.
  • 17. Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 2012;366:925– 31. doi: 10.1056/NEJMoa1112824.
  • 18. Golden EB, Demaria S, Schiff PB, Chachoua A, Formenti SC. An abscopal response to radiation andipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res 2013;1:365–72. doi: 10.1158/2326-6066
  • 19. Ehlers G, Fridman M. Abscopal effect of radiation in papillary adenocarcinoma. Br J Radiol 1973;46:220–2.
  • 20. Rees GJ, Ross CM. Abscopal regression following radiotherapy for adenocarcinoma. Br J Radiol 1983; 56:63–6.
  • 21. Ohba K, Omagari K, Nakamura T, et al. Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis. Gut 1998;43:575–7.
There are 21 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Yavuz Anacak

Serra Kamer This is me

Fatma Sert This is me

Publication Date September 30, 2015
Published in Issue Year 2015

Cite

APA Anacak, Y., Kamer, S., & Sert, F. (2015). Combining radiotherapy with immunotherapy. Marmara Medical Journal, 28(1), 40-44. https://doi.org/10.5472/mmj.34632
AMA Anacak Y, Kamer S, Sert F. Combining radiotherapy with immunotherapy. Marmara Med J. September 2015;28(1):40-44. doi:10.5472/mmj.34632
Chicago Anacak, Yavuz, Serra Kamer, and Fatma Sert. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal 28, no. 1 (September 2015): 40-44. https://doi.org/10.5472/mmj.34632.
EndNote Anacak Y, Kamer S, Sert F (September 1, 2015) Combining radiotherapy with immunotherapy. Marmara Medical Journal 28 1 40–44.
IEEE Y. Anacak, S. Kamer, and F. Sert, “Combining radiotherapy with immunotherapy”, Marmara Med J, vol. 28, no. 1, pp. 40–44, 2015, doi: 10.5472/mmj.34632.
ISNAD Anacak, Yavuz et al. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal 28/1 (September 2015), 40-44. https://doi.org/10.5472/mmj.34632.
JAMA Anacak Y, Kamer S, Sert F. Combining radiotherapy with immunotherapy. Marmara Med J. 2015;28:40–44.
MLA Anacak, Yavuz et al. “Combining Radiotherapy With Immunotherapy”. Marmara Medical Journal, vol. 28, no. 1, 2015, pp. 40-44, doi:10.5472/mmj.34632.
Vancouver Anacak Y, Kamer S, Sert F. Combining radiotherapy with immunotherapy. Marmara Med J. 2015;28(1):40-4.