ÇOCUKLUK ÇAĞINDA NADİR BİR PULMONER TÜMÖR: RABDOMYOSARKOMA

Abstract

Lokal olarak yaygın olan tümör, 4 kür kemoterapi sonrası çekilen bilgisayarlı tomografide minimal regresyon gösterdi. Kemoterapinin 12. haftasında halen hayati yapılara yaypışıklık gösteren tümörün lokal kontrolünü sağlamak amacı ile radyoterapi uygulandı. Radyoterapiyi takiben 3 VAC (vinkristin, aktinomisin D, siklofosfamid) kürü daha verildikten sonra tümörün progresyon göstermeye devam etmesi nedeni ile tedavi sonlandırıldı. Tanıdan 9 ay sonra hasta kaybedildi. Primer pulmoner rabdomyosarkomun prognostik özellikleri tartışıldı; persistan pulmoner semoptomları ve göğüs röntgeninde anormallikleri olan çocukların ayırıcı tanısında akla gelmesi gerektiği vurgulandı.

Anahtar Kelimeler: Malignite, Göğüs, Rabdomyosarkoma, Çocukluk

Keywords

• Malignite, Göğüs, Rabdomyosarkoma, Çocukluk

References

1. 1. Crist W, Gehan EA, Ragab AH, et al. The Third Intergroup Rhabdomyosarcoma Study. J Clin Oncol 1995;13:610-630.
2. 2. Maurer HM, Gehan EA, Beltangady M, et al. The Intergroup Rhabdomyosarcoma Study-II. Cancer 1993;71:1904-1922.
3. 3. Schiavetti A, Dominici C, Matrunola M, et al. Primary pulmonary rhabdomyosarcoma in childhood: clinico-biologic features in two cases with review of the literature. Med Pediatr Oncol 1996;26:201-207.
4. 4. Iqbal Y, Abdullah MF, Al Ja-Daan S, et al. Embryonal rhabdomyosarcoma of the lung in a child: Case report and literature rewiev. Ann Saudi Med 2002;22:91-92.
5. 5. Kotiloglu E, Kaya H, Kiyan G, et al. A rare primary pulmonary tumor of childhood. Turk J Pediatr 2002;44:156-159.
6. 6. Ozcan C, Celik A, Ural Z, et al. Primary pulmonary rhabdomyosarcoma arising within cystic adenomatoid malformation: a case report and review of the literature. J Pediatr Surg 2001;36:1062-1065.
7. 7. Hancock BJ, Di Lorenzo M, Youssef S, et al. Childhood primary pulmonary neoplasms. J Pediatr Surg 1993;28:1133-1136.
8. 8. Spunt SL, Lobe TE, Pappo AS, et al. Aggressive surgery is unwarranted for biliary tract rhabdomyosarcoma. J Pediatr Surg 2000;35:309-316.

9. 9. Parham DM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol 2001;14:506-514.
10. 10. Ramachandran PV . Intrathoracic rhabdomayosarcoma. A case report. Ultrasound international 2003; 9:16-19.
11. 11. McDermott VG, Mackenzie S, Hendry GM. Case report: primary intrathoracic rhabdomyosarcoma: a rare childhood malignancy. Br J Radiol 1993 ;66:937- 941.
12. 12. Eustace S, Fitzgerald E. Primary rhabdomyosarcoma of the diaphragm: an unusual cause of adolescent pseudo-achalasia. Pediatr Radiol 1993;23:622-623.
13. 13. Gupta AK, Mitra DK, Berry M. Primary embryonal rhabdomyosarcoma of the diaphragm in a child: case report. Pediatr Radiol 1999;29:823-825.
14. 14. Almberger M, Iannicelli E, Matrunola M, et al. Integrated diagnostic imaging of primary thoracic rhabdomyosarcoma. Eur Radiol 2001;11:506-508.
15. 15. Koscielniak E, Jurgens H, Winkler K, et al. Treatment of soft tissue sarcoma in childhood and adolescence. A report of the German Cooperative Soft Tissue Sarcoma Study. Cancer 1992;70:2557-2567.
16. 16. Lawrence W Jr, Anderson JR, Gehan EA, Maurer H. Pretreatment TNM staging of childhood rhabdomyosarcoma: a report of the Intergroup Rhabdomyosarcoma Study Group. Children's Cancer Study Group. Pediatric Oncology Group. Cancer. 1997;80:1165-1170.
17. 17. Lawrence W Jr, Hays DM, Heyn R, et al. Lymphatic metastases with childhood rhabdomyosarcoma. A report from the Intergroup Rhabdomyosarcoma Study. Cancer 1987;60:910-915.
18. 18. Mandell L, Ghavimi F, LaQuaglia M, Exelby P. Prognostic significance of regional lymph node involvement in childhood extremity rhabdomyosarcoma. Med Pediatr Oncol 1990;18:466- 471.
19. 19. Smith LM, Anderson JR, Qualman SJ, et al. Which patients with microscopic disease and rhabdomyosarcoma experience relapse after therapy? A report from the soft tissue sarcoma committee of the children's oncology group. J Clin Oncol 2001;19:4058-4064.