ÜLSERATİF KOLİTLİ HASTALARIN NON-NEOPLASTİK İNFLAME KOLONİK MUKOZALARINDA MİKROSATELLİT İNSTABİLİTESİ

Abstract

Giriş ve Amaç: Ülseratif kolit (ÜK), zemininde kanser gelişme riski yüksek olan kronik inflamatuar bir kolon hastalığıdır. ÜK ile ilişkili kanser gelişimine işaret edecek moleküler bir belirtece ihtiyaç duyulmaktadır. ÜK ile ilişkili kolorektal kanserlerde DNA tamir mekanizmasındaki yetersizliğin ve genomik mutasyonların bir belirteci olan mikrosatellit instabilitesinin (MSİ) varlığı gösterilmiştir. ÜK’te neoplastik ve şiddetli inflamasyon görülen neoplastik olmayan mukozada MSİ’ni gösteren bazı çalışmalar mevcuttur. Bu çalışmanın amacı neoplastik olmayan hafif-orta derecede inflame ÜK mukozasında MSİ’nin varlığını araştırmaktır. Gereç ve Yöntem: ÜK’li 29 hastanın inflame kolonik mucosa örneklerinde multipleks PCR (polimeraz zincir reaksiyonu) ile standart 5 adet belirteç (BAT-25, BAT-26, D2S123, D5S346, D17S250) kullanılarak MSİ’nin varlığı araştırıldı. Bulgular: ÜK’li hastaların neoplastik olmayan hafif-orta derecede inflame mukozalarında MSİ saptanmadı. Sonuç: ÜK’te MSİ’ni değerlendirirken mukozadaki inflamasyonun derecesi göz önünde bulundurulmalıdır.

Keywords

• Ülseratif kolit, Mikrosatellit instabilite

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