Year 2007,
Volume: 20 Issue: 3
,
154
-
160
,
25.06.2015
Abstract
-
Keywords
References
- 1. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163.
- 2. Stefanutti G, Vejchapipat P, Williams SR, Pierro A, Eaton S. Heart energy metabolism after intestinal ischaemia and reperfusion. J Pediatr Surg 2004; 39: 179-183.
- 3. Stoney RJ, Cunninghan CG. Acute mesenteric ischemia. Surgery 1993; 114: 489-490.
- 4. Grace PA. Ischaemia-reperfusion injury. Br J Surg 1994; 81: 637-647.
- 5. Kharbanda RK, Peters M, Walton B, et al. Ischemic preconditioning prevents endothelial injury and systemic activation during ischemia-reperfusion in humans in vivo. Circulation 2001; 103: 1624-1630.
- 6. Bhaskar L, Mathan MM, Balasubramanian KA. Oxygen free radical-induced damage during colonic ischemia/reperfusion in rats. Mol Cell Biochem 1995; 151 : 9-14.
- 7. Reichhalter R, Lillie C, Kobinger W. Effects of alinidine on survival and infarct size in rats with coronary artery occlusion. Eur J Pharmacol 1988; 157: 75-81.
- 8. Cai JJ, Morgan DA, Haynes WG, Martins JB, Lee HC. á2-adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo. Am J Physiol Heart Circ Physiol 2002; 283: 2606-2611.
- 9. Yuan SZ, Runold M, Hagberg H, Bona E, Lagercrantz H. Hypoxic-ischaemic brain damage in immature rats: effects of adrenergic modulation. Eur J Paed Neurol 2001; 5: 29-35.
- 10. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specifity and potency of medetomidine as an á2-adrenoceptor agonist. Eur J Pharmacol 1988; 150: 9-14.
- 11. Kuhmonen J, Haapalinna A, Sivenius J. Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat. J Neural Transm 2001; 108: 261-271.
- 12. Jolkkonen J, Puurunen K, Koistinaho JR, et al. Neuroprotection by the á2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur J Pharmacol 1999; 372: 31-36.
- 13. Nacif-Coelho C, Correa-Saler C, Chang LL, Maze M. The hypnotic response to the á2-adrenoceptor agonist, dexmedetomidine in the locus coeruleus of the rat. Anesthesiology 1994; 81: 1527-1534.
- 14. Surprenant A, Horstman DA, Akbarali H, Limbird LE. A point mutation of the á2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science 1992; 257: 977-980.
- 15. Vulliemoz Y, Shen H, Virag I. á2 Adrenoceptor agonists decrease cyclic guanosine 3’5’ monophosphate in the mouse brain. Anesthesiology 1996; 85: 544-550.
- 16. Talke P, Bickler PE. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology 1996; 85: 551-557.
- 17. Matsumato M, Zornow MH, Rabin BC, Maze M. The á2-adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res 1993; 627: 325-329.
- 18. Engelhard K, Werner C, Kaspar S, et al. Effect of the a2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesthesiology 2002; 96: 450-457.
DEKSMEDETOMİDİN İNFÜZYONUNUN SIÇANLARDA MEZENTER İSKEMİ- REPERFÜZYON HASARINDA OLUŞAN REAKTİF OKSİJEN TÜRLERİ ÜZERİNE ETKİSİ
Abstract
Amaç: Bu çalışmanın amacı; sıçanlarda oluşturulan mezenter iskemi-reperfüzyon modelinde intravenöz
uygulanan deksmedetomidinin reaktif oksijen ürün düzeyi üzerine etkilerinin araştırılmasıdır.
Yöntem: 300-320 g ağırlığında, 28 adet, erkek, Spraque-Dawley cinsi sıçan dört gruba ayrıldı (n:7). Sham
operasyonu geçiren iki gruptan; grup 1’deki sıçanlara (Kontrol grup, Grup K) ilaç uygulanmazken grup
2’deki sıçanlara 5 mg/kg/s deksmedetomidin infüzyonu yapıldı. Diğer iki gruba (grup 3 ve 4) süperior
mezenter arter ligasyonu ile 30 dk iskemi ve ardından 60 dk reperfüzyon uygulandı (I/R). İskemireperfüzyon
sırasında Grup 3’deki (I/R-S) sıçanlara 0.9% NaCl ve grup 4’deki (I/R-D) sıçanlara 5 mg/kg/h
deksmedetomidin infüzyonu yapıldı. İleumdan, luminal ve lusigenin kemiluminesans (KL), doku
miyeloperoksidaz aktivitesi, malondialdehid (MDA) ve glutatyon seviyesi ölçümleri için doku örnekleri
alındı.
Bulgular: Luminol KL seviyesi, doku miyeloperoksidaz aktivitesi (p
References
- 1. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312: 159-163.
- 2. Stefanutti G, Vejchapipat P, Williams SR, Pierro A, Eaton S. Heart energy metabolism after intestinal ischaemia and reperfusion. J Pediatr Surg 2004; 39: 179-183.
- 3. Stoney RJ, Cunninghan CG. Acute mesenteric ischemia. Surgery 1993; 114: 489-490.
- 4. Grace PA. Ischaemia-reperfusion injury. Br J Surg 1994; 81: 637-647.
- 5. Kharbanda RK, Peters M, Walton B, et al. Ischemic preconditioning prevents endothelial injury and systemic activation during ischemia-reperfusion in humans in vivo. Circulation 2001; 103: 1624-1630.
- 6. Bhaskar L, Mathan MM, Balasubramanian KA. Oxygen free radical-induced damage during colonic ischemia/reperfusion in rats. Mol Cell Biochem 1995; 151 : 9-14.
- 7. Reichhalter R, Lillie C, Kobinger W. Effects of alinidine on survival and infarct size in rats with coronary artery occlusion. Eur J Pharmacol 1988; 157: 75-81.
- 8. Cai JJ, Morgan DA, Haynes WG, Martins JB, Lee HC. á2-adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo. Am J Physiol Heart Circ Physiol 2002; 283: 2606-2611.
- 9. Yuan SZ, Runold M, Hagberg H, Bona E, Lagercrantz H. Hypoxic-ischaemic brain damage in immature rats: effects of adrenergic modulation. Eur J Paed Neurol 2001; 5: 29-35.
- 10. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specifity and potency of medetomidine as an á2-adrenoceptor agonist. Eur J Pharmacol 1988; 150: 9-14.
- 11. Kuhmonen J, Haapalinna A, Sivenius J. Effects of dexmedetomidine after transient and permanent occlusion of the middle cerebral artery in the rat. J Neural Transm 2001; 108: 261-271.
- 12. Jolkkonen J, Puurunen K, Koistinaho JR, et al. Neuroprotection by the á2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur J Pharmacol 1999; 372: 31-36.
- 13. Nacif-Coelho C, Correa-Saler C, Chang LL, Maze M. The hypnotic response to the á2-adrenoceptor agonist, dexmedetomidine in the locus coeruleus of the rat. Anesthesiology 1994; 81: 1527-1534.
- 14. Surprenant A, Horstman DA, Akbarali H, Limbird LE. A point mutation of the á2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science 1992; 257: 977-980.
- 15. Vulliemoz Y, Shen H, Virag I. á2 Adrenoceptor agonists decrease cyclic guanosine 3’5’ monophosphate in the mouse brain. Anesthesiology 1996; 85: 544-550.
- 16. Talke P, Bickler PE. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology 1996; 85: 551-557.
- 17. Matsumato M, Zornow MH, Rabin BC, Maze M. The á2-adrenergic agonist, dexmedetomidine, selectively attenuates ischemia-induced increases in striatal norepinephrine concentrations. Brain Res 1993; 627: 325-329.
- 18. Engelhard K, Werner C, Kaspar S, et al. Effect of the a2-agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesthesiology 2002; 96: 450-457.
There are 18 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Authors | |
| Publication Date | June 25, 2015 |
| IZ | https://izlik.org/JA36SA42ZE |
| Published in Issue | Year 2007 Volume: 20 Issue: 3 |