Thyroid hormones and BMI in obese children: One year follow up results

Abstract

Amaç: Bu çalışmanın amacı tiroid hormon düzeyleri ile obezite, lipid düzeyleri ve ağırlık değişiklikleri arasındaki ilişkiyi araştırmaktır. Hastalar ve Yöntemler: Beş ve onbir yaş aralığında normal, fazla kilolu ve obez çocukların TSH, sT4, lipid profili ve otoimmün antikor değerlerine bakılmıştır. TSH düzeyi yüksek olan çocuklar herhangi bir müdahale yapılmadan bir yıl sonra yeniden değerlendirilmiştir. Bulgular: Çalışmada 300 çocuk (126 obez, 74 fazla kilolu, 100 normal kilolu) değerlendirilmiştir. Yüksek TSH düzeyi sıklığı normal kilolu grupta %1.0, fazla kilolu grupta %9.5 ve obez grupta %11.9’dur (p=0.007). Bütün gruplarda sT4 düzeyleri normal bulunmuştur. Çocukların hiçbirinde otoimmun antikorlar pozitif değildir. Yüksek TSH’lı çocuklar normal TSH’lı çocuklara göre daha yüksek trigliserid düzeylerine sahiptir (p=0.028). Bir yıl sonra yapılan değerlendirmede, VKİ’de anlamlı düşüşle birlikte TSH düzeyinde de anlamlı bir düşüş saptanmıştır. Sonuç: TSH düzeyleri obez ve fazla kilolu çocuklarda yüksek olabilir. TSH yüksekliği olan obez ve fazla kilolu çocukların farmakolojik olarak tedavi edilmesine gerek yoktur, kilo vermek TSH düzeylerinin anlamlı olarak azalmasını sağlar.

Keywords

• TSH, VKİ, Çocuk, Obezite, Fazla kilolu, Tiroid

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