Case Report
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A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired

Year 2018, , 47 - 49, 26.02.2018

İsmet Cengiç Derya Türeli Hilal Altaş Onur Buğdaycı

https://doi.org/10.5472/marumj.398944

Abstract

Cervical roentgenogram revealed a long-segment cervicothoracic

vertebral fusion spanning 8 adjacent spinal levels. The patient was

evaluated with computed tomography (CT) and magnetic resonance

(MR) imagings of the spine, electromyography (EMG) and growth

differentiation factor 6 (GDF6) gene mutation analysis. Imaging

findings were atypical for congenital block vertebrae and there

was no GDF6 mutation. A revision of very old medical records and

patient’s recollections revealed long-term stay in sanatorium for

rehabilitation of chronic partially-treated brucella spondylodiscitis

during adolescence. Block vertebrae spanning several levels have

previously been reported; but, this is the first report of an acquired

cervicothoracic fusion spanning 8 adjacent vertebral bodies.

Keywords

Cervicothoracic vertebral synostosis Klippel – Feil syndrome Magnetic resonance imaging Brucellosis Growth differentiation factor 6

References

  • Thawait GK, Chhabra A, Carrino JA. Spine segmentation and enumeration and normal variants. Radiol Clin North Am 2012;50:587-98. doi: 10.1016/j.rcl.2012.04.003
  • Kumar R, Guinto FC, Jr, Madewell JE, Swischuk LE, David R. The vertebral body: radiographic configurations in various congenital and acquired disorders. Radiographics 1988;8:455-85. doi:10.1148/radiographics.8.3.3380991
  • Klimo P Jr , Rao G, Brockmeyer D. Congenital anomalies of the cervical spine. Neurosurg Clin N Am 2007;18:463-78. doi:10.1016/j.nec.2007.04.005
  • Nguyen VD, Tyrrel R. Klippel-Feil syndrome: patterns of bony fusion and wasp-waist sign. Skeletal Radiol 1993;22:519-23.
  • Guille JT, Sherk HH. Congenital osseous anomalies of the upper and lower cervical spine in children. J Bone Joint Surg Am 2002;84-A:277-88.
  • Yuksel M, Karabiber H, Yuksel KZ, Parmaksiz G. Diagnostic importance of 3D CT images in Klippel-Feil Syndrome with multiple skeletal anomalies: a case report. Korean J Radiol 2005;6:278-81. doi:10.3348/kjr.2005.6.4.278
  • McBride WZ. Klippel-Feil syndrome.Am Fam Physician 1992;45:633-5.
  • Theiss SM, Smith MD, Winter RB. The long-term follow-up of patients with Klippel-Feil syndrome and congenital scoliosis. Spine (Phila Pa 1976). 1997 ;22:1219-22.

Sekiz ardışık segmenti kapsayan çok nadir bir servikotorakal vertebral sinostoz olgusu: konjenital mi, edinsel mi?

Year 2018, , 47 - 49, 26.02.2018

İsmet Cengiç Derya Türeli Hilal Altaş Onur Buğdaycı

https://doi.org/10.5472/marumj.398944

Abstract

Yaşlı bir kadın hasta travma sonrası akut boyun ağrısı ile başvurdu.

Servikal direkt grafisinde 8 ardışık spinal seviyeyi kapsayan

uzun segment servikotorakal vertebral füzyon saptandı. Hasta

spinal bilgisayarlı tomografi (BT) ve magnetik rezonans (MR)

görüntüleme, elektromiyografi (EMG), ve büyüme-farklılaşma

faktörü 6 [Growth differentiation factor 6 (GDF6)] gen mutasyonu

analizi ile detaylı tetkik edildi. Görüntüleme bulguları konjenital

blok vertebra için atipik olan olguda GDF6 gen mutasyonu

saptanmadı. Hastanın eski tıbbi raporları ve anamnezinde adolesan

dönemde kronik ve kısmen tedavi edilmiş brucella spondilodiskiti

rehabilitasyonu amacıyla sanatoryumda uzun dönemli yatış

mevcut idi. Birkaç seviyeyi kapsayan blok vertebra olguları daha

önceden bildirilmiş olmakla birlikte; bu, 8 ardışık vertebral cismi

kapsayan ilk edinsel servikotorakal füzyon olgusudur.

Keywords

Servikotorakal vertebral siyanoz Klippel- Feil sendromu Magnetik rezonans görüntüleme Brusellozis Büyüme-farklılaşma faktörü 6

References

  • Thawait GK, Chhabra A, Carrino JA. Spine segmentation and enumeration and normal variants. Radiol Clin North Am 2012;50:587-98. doi: 10.1016/j.rcl.2012.04.003
  • Kumar R, Guinto FC, Jr, Madewell JE, Swischuk LE, David R. The vertebral body: radiographic configurations in various congenital and acquired disorders. Radiographics 1988;8:455-85. doi:10.1148/radiographics.8.3.3380991
  • Klimo P Jr , Rao G, Brockmeyer D. Congenital anomalies of the cervical spine. Neurosurg Clin N Am 2007;18:463-78. doi:10.1016/j.nec.2007.04.005
  • Nguyen VD, Tyrrel R. Klippel-Feil syndrome: patterns of bony fusion and wasp-waist sign. Skeletal Radiol 1993;22:519-23.
  • Guille JT, Sherk HH. Congenital osseous anomalies of the upper and lower cervical spine in children. J Bone Joint Surg Am 2002;84-A:277-88.
  • Yuksel M, Karabiber H, Yuksel KZ, Parmaksiz G. Diagnostic importance of 3D CT images in Klippel-Feil Syndrome with multiple skeletal anomalies: a case report. Korean J Radiol 2005;6:278-81. doi:10.3348/kjr.2005.6.4.278
  • McBride WZ. Klippel-Feil syndrome.Am Fam Physician 1992;45:633-5.
  • Theiss SM, Smith MD, Winter RB. The long-term follow-up of patients with Klippel-Feil syndrome and congenital scoliosis. Spine (Phila Pa 1976). 1997 ;22:1219-22.
There are 8 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Reports
Authors

İsmet Cengiç This is me

Derya Türeli This is me

Hilal Altaş This is me

Onur Buğdaycı This is me

Publication Date February 26, 2018
Published in Issue Year 2018

Cite

APA Cengiç, İ., Türeli, D., Altaş, H., Buğdaycı, O. (2018). A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired. Marmara Medical Journal, 31(1), 47-49. https://doi.org/10.5472/marumj.398944
AMA Cengiç İ, Türeli D, Altaş H, Buğdaycı O. A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired. Marmara Med J. January 2018;31(1):47-49. doi:10.5472/marumj.398944
Chicago Cengiç, İsmet, Derya Türeli, Hilal Altaş, and Onur Buğdaycı. “A Very Rare Case of Cervicothoracic Vertebral Synostosis Spanning Eight Adjacent Segments: Congenital Vs Acquired”. Marmara Medical Journal 31, no. 1 (January 2018): 47-49. https://doi.org/10.5472/marumj.398944.
EndNote Cengiç İ, Türeli D, Altaş H, Buğdaycı O (January 1, 2018) A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired. Marmara Medical Journal 31 1 47–49.
IEEE İ. Cengiç, D. Türeli, H. Altaş, and O. Buğdaycı, “A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired”, Marmara Med J, vol. 31, no. 1, pp. 47–49, 2018, doi: 10.5472/marumj.398944.
ISNAD Cengiç, İsmet et al. “A Very Rare Case of Cervicothoracic Vertebral Synostosis Spanning Eight Adjacent Segments: Congenital Vs Acquired”. Marmara Medical Journal 31/1 (January 2018), 47-49. https://doi.org/10.5472/marumj.398944.
JAMA Cengiç İ, Türeli D, Altaş H, Buğdaycı O. A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired. Marmara Med J. 2018;31:47–49.
MLA Cengiç, İsmet et al. “A Very Rare Case of Cervicothoracic Vertebral Synostosis Spanning Eight Adjacent Segments: Congenital Vs Acquired”. Marmara Medical Journal, vol. 31, no. 1, 2018, pp. 47-49, doi:10.5472/marumj.398944.
Vancouver Cengiç İ, Türeli D, Altaş H, Buğdaycı O. A very rare case of cervicothoracic vertebral synostosis spanning eight adjacent segments: congenital vs acquired. Marmara Med J. 2018;31(1):47-9.