Erişkinlerde obezite ve tiroid fonksiyonu arasındaki ilişki

Abstract

Amaç: Obezite, pek çok komorbid hastalığın seyrini olumsuz

etkilemektedir. Bu çalışmanın amacı obezite ve tiroid fonksiyonu

arasındaki ilişkiyi ortaya koymaktır.

Gereç ve Yöntem: Bu çalışma kesitsel bir çalışmadır. 2011

Aralık ve 2012 Aralık yılları arasında Marmara Universite

Hastahane’si Aile hekimliği ve Dahiliye polikliniklerine başvuran

erişkin yaş hastalar bu çalışmaya dahil edilmiştir. Hastaların

boy ve kiloları ölçülmüş, vücut kitle indeksi (VKİ) değerleri

hesaplanmıştır. Kanları alınmış ve tiroid stimulant hormonu

(TSH), serbest tşiroksin (fT4), total kolesterol, düşük dansitesli

lipoprotein (LDL), yüksek dansiteli lipoprotein (HDL), trigliserid

ve glukoz değerlerini ölçen tahliller yapılmıştır. Katılımcılar,

VKİ değerlerine göre üç gruba ayrılmış ve grupların verileri

karşılaştırılmıştır.

Bulgular: Çalışmaya 618 hasta dahil edilmiştir (%53 kadın/

%47 erkek). Ortalama yaş 43±15 ti. Normal kilolu grupta 175

(%28.3), fazla kilolu grupta 242 (%39.2) ve obez grupta 201

(%32.5) kişi yer almaktaydı. Gruplar arasında TSH ve fT4

değerleri açısından istatistiksel olarak anlamlı bir fark bulunmadı.

Gruplar arasında lipid profili açısından istatistiksel olarak anlamlı

fark bulundu.Fazla kilolu ve obez grubun aterojenik lipid değerleri

(total kolesterol, LDL ve trigliserid) ve glukoz değerleri normal

kilolu gruba kıyasla yüksek, HDL değerleri ise düşük bulundu

(P<0.05), fazla kilolu ve obez grup arasında lipid değerleri ve

glukoz değeri açısından istatistiksel olarak anlamlı bir fark

bulunmamıştır (P>0.05).

Sonuç: Bu çalışma, obezite ve tiroid fonksiyonu arasında

ilişki olmadığını gösteren literatürdeki ender çalışmalardan biridir.

Keywords

• Obezite,Erişkin,Tiroid Fonksiyon Testleri

Relationship between obesity and thyroid function in adults

Abstract

Objectives: Obesity affects prognosis of many comorbid diseases

negatively. This study was conducted to investigate the relationship

between obesity and thyroid function.

Materials and Methods: This cross-sectional study was conducted

between December 2011 and December 2012. Consecutively selected

adults who applied to the outpatient clinics of Family Medicine and

Internal Medicine, at Marmara University Hospital were recruited in

the study. Height and weight were measured and body mass index

(BMI) was calculated. Thyroid-stimulating hormone (TSH), free

thyroxine (fT4), total cholesterol, low-density lipoprotein (LDL),

high-density lipoprotein (HDL), triglyceride and glucose levels were

measured for every participant. According to their BMI, participants

were divided into three groups as normal weight (<25), overweight (25-

30) and obese (≥30).

Results: Data of 618 participants (53% female/47% male)

was analyzed. Mean age was 43±15. There were 175 (28.3%)

participants in normal weight, 242 (39.2%) in overweight and 201

(32.5%) in obese groups. No statistically significant difference

was found between groups in terms of TSH or fT4. Statistically

significant difference was found in terms of lipid profiles and

blood glucose between groups. Atherogenic lipid levels (total

cholesterol, LDL and triglyceride) and blood glucose were

higher and HLD levels were lower in overweight or obese groups (P<0.05) but there were no statistically significant differences

between overweight and obese groups (P>0.05).

Conclusion: This study is one of the few studies in the

literature showing that there is no relationship between obesity and

thyroid function.

Keywords

• Obesity,Adults,Thyroid function tests

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