Polikistik over sendromunda insülin rezistansı ve nöropeptid Y düzeyleri arasındaki ilişkinin araştırılması

Year 2019, , 1 - 6, 29.01.2019

Tolga Kosecı Omer Kaya , Veysel Haksoyler Didem Derıcı Yıldırım Kerem Sezer

https://doi.org/10.5472/marumj.500032

Abstract

Amaç: Çalışmanın amacı, polikistik over sendromu (PKOS)

patogenezinde önemli yeri olan nöropeptid Y (NPY) ve insülin

direnci arasındaki ilişkinin araştırılmasıdır.

Gereçler ve Yöntemler: Bu çalışma Mayıs 2012 ve Mayıs 2013

tarihleri arasında yapılmıştır. Çalışmaya doğurganlık çağındaki 45

PKOS hastası ve 44 sağlıklı kontrol grubu dahil edilmiştir. PKOS

grubuna erken foliküler fazda insulin, açlık kan şekeri, folikül

stimüle edici hormon (FSH), luteize edici hormon (LH), prolaktin,

testesteron, dehidroepiandrosteron sülfat (DHEA-S), tiroid

stimüle edici hormon (TSH), kortizol, östrodiol ve NPY düzeyleri

bakılırken, kontrol grubuna insülin, açlık kan şekeri, prolaktin,

DHEA-S, TSH, kortizol, 17-OH progesteron düzeyleri incelendi.

Homeostatik model insulin direnci değerlendirme (HOMA-IR)

testi skorları hesaplandı ve antropometrik ölçümler kaydedildi.

Pelvik ultrasonografi yapıldı.

Bulgular: İnsulin direncini gösteren açlık kan insülin düzeyi

ve HOMA-IR skoru, obez PKOS grubunda normal kilolu PKOS

ve kontrol grubuna göre yüksek bulundu. NPY düzeyleri obezyüksek

kilolu PKOS grubunda normal kilolu PKOS ve kontrol

grubuna göre yüksek bulundu ancak istatistiksel olarak anlamlı

değildi (P>0,05). NPY düzeyleri insülin rezistansı olan ve olmayan

hastalar arasında değişiklik göstermedi.

Sonuç: İnsülin rezistansı ve NPY düzeyleri arasında

korelasyon saptanmadı ancak NPY düzeyleri, kilolu PCOS

hastalarında yüksekti.

Keywords

Polikistik over sendromu, İnsülin rezistansı, Nöropeptid Y

Investigation of the relationship between insulin resistance and neuropeptide Y levels in polycystic ovary syndrome

Abstract

Objective: The aim of study is to investigate the relationship between neuropeptide Y (NPY) and insulin resistance which is important in the pathogenesis of poliycstic ovary syndrome (PCOS).
Material and Methods: This study was conducted between May 2012 and May 2013. The study included 45 patients with PCOS and 44 healthy controls at productive age. Insulin, fasting blood sugar, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactine, testestorone, dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), cortisole, estradiol, NPY levels were measured at early follicular phase in patients with PCOS while insulin, fasting blood sugar, prolactine, DHEA-S, TSH, cortisole, 17-OH progesterone levels were measured in control group. Homeostatic model assessment for insulin resistance (HOMA-IR) scores were calculated and antrepometric measures recorded. Pelvic ultrasonography was performed.
Results: Fasting insulin levels and HOMA-IR scores showed insulin resistance to be higher in obese patients with PCOS than healthy control subjects and patients with normal weight PCOS. NPY levels found to be higher in obese-overweight patients with PCOS than healthy control subjects and patients with normal weight but it was not statistically significant (P>0.05). NPY levels did not differ in patients with and without insulin resistance.
Conclusion: No correlation dedected between insülin resistance and NPY levels but NPY levels were high in overweight PCOS patients.

Keywords

Poliycstic ovary syndrome, Insulin resistance, Neuropeptide Y

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