Fat graft survival inside pocket for silicone implant

Year 2020, , 42 - 47, 31.05.2020

Fatma Nihal Durmus Kocaaslan Melekber Cavus Ozkan Fatma Betul Tuncer Mehmet Bayramıclı

https://doi.org/10.5472/marumj.737734

Abstract

Objective: The aim of this study was to investigate the survival potential of the fat grafts inside the implant capsule in an experimental
setting.
Materials and Methods: Twenty male Wistar albino rats were used. A two-staged surgical procedure was performed. In the first stage,
silicone sheets were placed in the subcutaneous plane on the left side of each rat. On day 60, fat grafts injected into the silicone capsule
either by removing the silicone sheaths or leaving the silicone sheaths in their place. In both groups, the same amount of the fat grafts
was injected into the right side of the dorsal subcutaneous plane of the rats and they served as their own controls. The findings were
evaluated according to the histopathological criteria.
Results: There was no statistically significant difference in the inflammatory cell infiltration, fibrosis, and necrotic adipocytes among
the groups. Although, the fat viability rate was higher in control groups, there was no statistically significant difference compared to
the capsule or silicone groups (p>0.05).
Conclusion: Our study results suggest that implant capsule is a hospitable environment and resection of the capsule is unnecessary, if
silicone implants are expected to be removed following fat injection.

Keywords

Fat graft, Lipofilling, Adipocyte, Capsule, Silicone implant, Prosthesis

References

• [1] Silva EN, Ribas-Filho JM, Czeczko NG, et al. Histological evaluation of capsules formed by silicone implants coated with polyurethane foam and with a textured surface in rats. Acta Cir Bras 2016 ;31:774-82. doi: 10.1590/ S0102.865.0201601.200.00001
• [2] Imber G, Schwager RG, Guthrie RH Jr, Gray GF. Fibrous capsule formation after subcutaneous implanation of synthetic materials in experimental animals. Plast Reconstr Surg 1974 ;54:183-6.
• [3] Wagner H, Beller FK, Pfautsch M. Electron and light microscopy examination of capsules around breast implants. Plast Reconstr Surg 1977;60:49-55.
• [4] Sarifakioglu N, Gökrem S, Bingul F, Ustun H, Aslan G. The fate of transplanted fibrous capsule as an autogenous graft. Plast Reconstr Surg 2005 ;115:1087-94.
• [5] Simonacci F, Grieco MP, Bertozzi N, Raposio E. Autologous fat transplantation for secondary breast reconstruction: our experience. G Chir. 2017 May-Jun;38(3):117-123.
• [6] Streit LM D, Lhotsky R, Mestak O. Autologous fat transfer, breast lipomodelling and fat transfer to the face: Current gold standards and emerging new data. Acta Chir Plast 2017 ;59:97-108.
• [7] Chiu CH. Does Stromal Autologous fat transfer, breast lipomodelling and fat transfer to the face: Current gold standards and emerging new data. Aesthet Surg J 2018 Feb 9. [Epub ahead of print]
• [8] Boccara D, Haddad J, Chaouat M, Serror K, Mimoun M. Treating breast conservation therapy defects with brava and fat grafting: technique, outcomes, and safety profile. Plast Reconstr Surg 2018;141:965e. doi: 10.1097/PRS.000.000.0000004299.
• [9] Delay E, Meruta AC, Guerid S. Indications and controversies in total breast reconstruction with lipomodeling. Clin Plast Surg2018 ;45:111-7. doi: 10.1016/j.cps.2017.08.009.
• [10] Delay E, Guerid S, Meruta AC. Indications and controversies in lipofilling for partial rreast reconstruction. Clin Plast Surg2018;45:101-10. doi: 10.1016/j.cps.2017.08.008.
• [11] Delay E, Garson S, Tousson G, Sinna R. Fat injection to the breast: technique, results, and indications based on 880 procedures over 10 years. Aesthet Surg J 2009 ;29:360-76. doi: 10.1016/j.asj.2009.08.010.
• [12] Spear SL, Wilson HB, Lockwood MD. Fat injection to correct contour deformities in the reconstructed breast. Plast Reconstr Surg 2005;116:1300e5.
• [13] Hammond DC, O’Connor EA, Scheer JR. Total envelope fat grafting: a novel approach in breast reconstruction. Plast Reconstr Surg 2015;135:691-4. doi: 10.1097/PRS.000.000.0000000968.
• [14] FishRE. Anesthesia and Analgesia in Laboratory Animals. 2nd ed. ACLAM, London:Academic Press, 2008.
• [15] Bayramiçli M.Anaesthesia, analgesia and drugs. In Bayramiçli M, ed. Experimental Microsurgery-Basic Research, Tissue and Organ Transplantation Models (Turkish). Istanbul:Argos Publications, 2005: 207-30.
• [16] Condé-Green A, Wu I, Graham I, et al. Comparison of 3 techniques of fat grafting and cell-supplemented lipotransfer in athymic rats: a pilot study. Anesthet Surg J 2013 ;33:713-21. doi: 10.1177/1090820X13487371.
• [17] Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg 1997 ;24:347-67.
• [18] [18]. Simonacci F, Bertozzi N, Grieco MP, Grignaffini E, Raposio E. Autologous fat transplantation for breast reconstruction: A literature review. Ann Med Surg (Lond) 2016 ;12:94-100. eCollection 2016 Dec.
• [19] Coleman SR, Saboeiro AP. Fat grafting to the breast revisited: safety and efficacy, Plast Reconstr Surg2007;119:775-85.
• [20] Beck M, Amar O, Bodin F, Lutz JC, Lehmann S, Bruant-Rodier C. Evaluation of breast lipofilling after sequelae of conservative treatment for cancer. EurJPlastic Surg 2012 ;35:221-8. doi: 10.1007/s00238.011.0606-x
• [21] Taylor SR. Effect of surface texture on the soft tissue response to polymer implants. J Biomed Mater Res1983 ;17:205-27.
• [22] Thomson H. The fate of the pseudosheath pocket around silicone implants. Plast Reconstr Surg 1973 ;51:667-71.
• [23] Imran D, Javaid M, Lewis D, Attar KH. Capsular flap for correction of contour deformities of the breast. Ann Plast Surg 2005;54:662-3.
• [24] Yazawa M, Mori T, Tuchiya K, Nakayama Y, Ogata H, Nakajima T. Influence of vascularized transplant bed on fat grafting. Wound Rep Reg 2006 ;14:586-92.
• [25] Yager DR, Nwomeh BC. The proteolytic environment of chronic wounds. Wound Repair Regen 1999 ;7:433-41.
• [26] Majd H, Scherer BSS, Boo S, et al. Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants. Biomaterials 2015 ;54:136-47. doi: 10.1016/j. biomaterials.2015.03.027.
• [27] Wagenführ-Júnior J, Ribas Filho JM, Nascimento MM, Ribas FM, Wanka MV, Godoi Ade L. Histopathological reaction over prosthesis surface covered with silicone and polyurethane foam implanted in rats. Acta Cir Bras 2012 ;27:866-73.