Sıçanda stres ile uyarılan mide ülserinde simvastatin’in etkisi

Year 2016, Volume: 29 Issue: 1, 1 - 7, 04.03.2016

Elif Bahadır Elif Bahadır Muhammet Bulut Beyza Kabayuka Beyza Kabayuka Ece Söylem Şenkal Abdullah Avlaç Meral Yüksel Feriha Ercan İnci Alican İnci Alican

https://doi.org/10.5472/MMJoa.2901.01

Abstract

Amaç: Bu çalışmada sıçanlarda stres ile uyarılan mide ülserinde
simvastatin’in (SİM) olası koruyucu etkisini değerlendirmek
amaçlanmıştır.
Gereç ve Yöntem: Sprague-Dawley sıçanlarda (250-300
gr) soğuk-kısıtlama stres uygulaması ile mide ülseri oluşturuldu.
Stres öncesi 21 gün süreyle SİM (10 mg/kg/day; oral yolla) veya
fizyolojik tuzlu su (1 ml; oral yolla) uygulandı. Bir grup sıçan
21. günde SİM öncesi selektif olmayan nitrik oksit sentaz (NOS)
inhibitörü L-NAME (50 mg/kg; intraperitoneal) veya selektif
olmayan siklooksijenaz (COX) inhibitörü indometazin (İndo; 5
mg/kg; subkutan) verildi. Mideler makroskopik ve mikroskopik
olarak incelendi ve biyokimyasal analizler için saklandı.
Bulgular: Stres grubunda lezyonların şiddeti SİM ile azaldı
ancak L-NAME veya İndo ile anlamlı bir değişiklik göstermedi.
Stres mide miyeloperoksidaz aktivitesini kontrol düzeyine kıyasla
artırdı (p

Keywords

Ülser, Nitrik oksit sentaz, Siklooksijenaz, Sıçan, Stres

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