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Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis

Year 1991, Volume: 4 Issue: 4, 141 - 148, 01.12.1991

S. Arbak

Abstract

Studies have shown that prostaglandin E2 (PG E2) can prevent liver necrosis due to several agents. Dimethyl sulfoxide (DMSO) is also known with its cytoprotective efficiency. To determine the degree of cytoprotective effectivenesses of these two agents, 20 female rats were divided into 5 groups.

Livers of rats treated only with carbon tetrachloride showed severe necrosis. In groups pretreated with prostaglandin E2 and dimethyl sulfoxide, degree of necrosis was very low. Especially prostaglandin E2 could perform this cytoprotection very well.

It is concluded that these two cytoprotective agents could prevent carbon tetrachloride-induced liver cell necrosis in the rats at different degrees.

Keywords

Carbon tetrachloride prostaglandin E2 dimethyl sulfoxide cytoprotection

References

  • Robert A. et al. Cytoprotection by prostaglandins. Gastroenterol 1979; 77: 761-767.

Year 1991, Volume: 4 Issue: 4, 141 - 148, 01.12.1991

S. Arbak

Abstract

References

  • Robert A. et al. Cytoprotection by prostaglandins. Gastroenterol 1979; 77: 761-767.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Editorial
Authors

S. Arbak This is me

Publication Date December 1, 1991
Published in Issue Year 1991 Volume: 4 Issue: 4

Cite

APA Arbak, S. (1991). Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Medical Journal, 4(4), 141-148.
AMA Arbak S. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J. December 1991;4(4):141-148.
Chicago Arbak, S. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal 4, no. 4 (December 1991): 141-48.
EndNote Arbak S (December 1, 1991) Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Medical Journal 4 4 141–148.
IEEE S. Arbak, “Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis”, Marmara Med J, vol. 4, no. 4, pp. 141–148, 1991.
ISNAD Arbak, S. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal 4/4 (December 1991), 141-148.
JAMA Arbak S. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J. 1991;4:141–148.
MLA Arbak, S. “Light and Electronmicroscopical Investigations on the Cytoprotective Effects of Prostaglandin E2 and Dimethyl Sulfoxide in Carbon Tetrachloride-Induced Liver Necrosis”. Marmara Medical Journal, vol. 4, no. 4, 1991, pp. 141-8.
Vancouver Arbak S. Light and electronmicroscopical investigations on the cytoprotective effects of prostaglandin e2 and dimethyl sulfoxide in carbon tetrachloride-induced liver necrosis. Marmara Med J. 1991;4(4):141-8.