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Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone

Year 1992, Volume: 5 Issue: 1, 27 - 30, 01.01.1992

Abstract

15 patients with severe aplastic anemia were treated with an immunosuppresive regimen consisting of Cyclosporin-A(CsA) and highdose méthylprednisolone (HMP). Initially CsA was given orally at a dosage of 10 mg/kg/day and monitoring the serum level of the drug, blood levels of 200-500 ng/ml were maintained thereafter. CsA treatment was continued at least 3 months at which time the treatment was terminated in unresponsive patients depending on the peripheral cell counts. HMP was administered simultaneously with CsA at 30 mg/kg/day IV for 3 days, 20 mg/kg/day IV for 3 days and 10 mg/kg/day IV for 4 days. Within 3 months improvement of hematopoiesis was seen in 6 patients (40 %). First signs of response were seen in 21-69 (34) days. This was followed by complete remission in 3 patients, partial remission in 2 patients and minimal improvement in 1 patient. Remissions were proved to be dependent on the continued administration of CsA. Sequential changes of T-cell subsets using APAAP method revealed an increasing ratio of T-helper cells to T-suppressor cells. This Observation strongly suggests the role of T-cells in the pathogenesis of some cases of aplastic anemia.

References

  • Alter BP. The bone marrow failure syndroms. In: nathan OD. Oski FA (eds). Hematology of Infancy and Childhood. 3rd ed. Philadelphia: WB Saunders Company 1987.
Year 1992, Volume: 5 Issue: 1, 27 - 30, 01.01.1992

Abstract

References

  • Alter BP. The bone marrow failure syndroms. In: nathan OD. Oski FA (eds). Hematology of Infancy and Childhood. 3rd ed. Philadelphia: WB Saunders Company 1987.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Editorial
Authors

N. Üskent This is me

M. Danacı This is me

M. Özel This is me

M. Yaylacı This is me

H. Tor This is me

Publication Date January 1, 1992
Published in Issue Year 1992 Volume: 5 Issue: 1

Cite

APA Üskent, N., Danacı, M., Özel, M., Yaylacı, M., et al. (1992). Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone. Marmara Medical Journal, 5(1), 27-30.
AMA Üskent N, Danacı M, Özel M, Yaylacı M, Tor H. Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone. Marmara Med J. January 1992;5(1):27-30.
Chicago Üskent, N., M. Danacı, M. Özel, M. Yaylacı, and H. Tor. “Treatment of Severe Aplastic Anemia With Cyclosporin-a and High-Dose Methylprednisolone”. Marmara Medical Journal 5, no. 1 (January 1992): 27-30.
EndNote Üskent N, Danacı M, Özel M, Yaylacı M, Tor H (January 1, 1992) Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone. Marmara Medical Journal 5 1 27–30.
IEEE N. Üskent, M. Danacı, M. Özel, M. Yaylacı, and H. Tor, “Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone”, Marmara Med J, vol. 5, no. 1, pp. 27–30, 1992.
ISNAD Üskent, N. et al. “Treatment of Severe Aplastic Anemia With Cyclosporin-a and High-Dose Methylprednisolone”. Marmara Medical Journal 5/1 (January 1992), 27-30.
JAMA Üskent N, Danacı M, Özel M, Yaylacı M, Tor H. Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone. Marmara Med J. 1992;5:27–30.
MLA Üskent, N. et al. “Treatment of Severe Aplastic Anemia With Cyclosporin-a and High-Dose Methylprednisolone”. Marmara Medical Journal, vol. 5, no. 1, 1992, pp. 27-30.
Vancouver Üskent N, Danacı M, Özel M, Yaylacı M, Tor H. Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone. Marmara Med J. 1992;5(1):27-30.