Histopathologic diagnosis of chronic viral hepatitis

Year 2016, Special Issue :2 Gastroenterology and Hepatology Viral Hepatitis, 18 - 28, 01.08.2016

Çiğdem Ataizi Çelikel

https://doi.org/10.5472/MMJsi.2901.05

Cited By: 1

Abstract

Morphological evaluation of the liver continues to play a centralrole for the diagnosis, grading and staging of chronic viral hepatitis.The defining morphology is necroinflammation, that is hepatocyteinjury and inflammation. Hepatocyte injury is usually irreversible,and presents as apoptosis and/or necrosis. Mononuclear cellinfiltration of the portal tracts, that is usually accompanied byperiportal (interface) and lobular inflammation is typical. Continuednecroinflammatory activity at the limiting plate destroyingperiportal parenchyma initiates fibrogenesis leading to cirrhosis.Fibrosis can be reversible with fragmentation of scar tissue,resolving vascular derangements and parenchymal regeneration.Grading is a measure of the intensity of necroinflammatory activityand staging is a measure of fibrosis and architectural alteration.Besides staging, Laennec scoring system, subdividing cirrhosisthat is based on histologic parameters of fibrous septa width andnumber, has been advised to be used in reporting chronic viralhepatitis.Keywords: Viral hepatitis, Grading, Staging, Biopsy

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