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The effect of hormone replacement therapy in menopause on cardioprotection

Year 1993, Volume: 6 Issue: 3, 110 - 115, 01.08.1993

Abstract

Cardiovascular disease (CVD) is the leading cause of death in women, and after menopause the incidence increases rapidly. The premenopausal state and estrogen status, appear to be a prophylactic against the mortality risk from CVD. The protective effect is believed to be mediated by beneficial changes in cholesterol levels. Estrogen decreases low density lipoprotein cholesterol (LDL-C) and increases high density lipoprotein cholesterol (HDL-C). The other possible mechanism is the direct effect of estrogen on arterial intima. The type and route of estrogen used in hormone replacement therapy determines the positive and negative effect of estrogen on the cardiovascular system. Most studies show a 50% or greater reduction in CVD and related mortality with postmenopausal estrogen administration. Progestogen addition to hormone replacement, may attenuate the beneficial effects of estrogen on cholesterol. However if used in low doses progesteron may not exert this negative effect on the cardivascular system.

References

  • Kannel W, Hjrtland MC, Mc Hamara FM, Gordon T. Menopause and risk of cardiovascular disease: The Framingham Study. Ann Intern Med 1976,85: 447-452.
Year 1993, Volume: 6 Issue: 3, 110 - 115, 01.08.1993

Abstract

References

  • Kannel W, Hjrtland MC, Mc Hamara FM, Gordon T. Menopause and risk of cardiovascular disease: The Framingham Study. Ann Intern Med 1976,85: 447-452.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

M. Erenus This is me

K. Kutlay This is me

Publication Date August 1, 1993
Published in Issue Year 1993 Volume: 6 Issue: 3

Cite

APA Erenus, M., & Kutlay, K. (1993). The effect of hormone replacement therapy in menopause on cardioprotection. Marmara Medical Journal, 6(3), 110-115.
AMA Erenus M, Kutlay K. The effect of hormone replacement therapy in menopause on cardioprotection. Marmara Med J. August 1993;6(3):110-115.
Chicago Erenus, M., and K. Kutlay. “The Effect of Hormone Replacement Therapy in Menopause on Cardioprotection”. Marmara Medical Journal 6, no. 3 (August 1993): 110-15.
EndNote Erenus M, Kutlay K (August 1, 1993) The effect of hormone replacement therapy in menopause on cardioprotection. Marmara Medical Journal 6 3 110–115.
IEEE M. Erenus and K. Kutlay, “The effect of hormone replacement therapy in menopause on cardioprotection”, Marmara Med J, vol. 6, no. 3, pp. 110–115, 1993.
ISNAD Erenus, M. - Kutlay, K. “The Effect of Hormone Replacement Therapy in Menopause on Cardioprotection”. Marmara Medical Journal 6/3 (August 1993), 110-115.
JAMA Erenus M, Kutlay K. The effect of hormone replacement therapy in menopause on cardioprotection. Marmara Med J. 1993;6:110–115.
MLA Erenus, M. and K. Kutlay. “The Effect of Hormone Replacement Therapy in Menopause on Cardioprotection”. Marmara Medical Journal, vol. 6, no. 3, 1993, pp. 110-5.
Vancouver Erenus M, Kutlay K. The effect of hormone replacement therapy in menopause on cardioprotection. Marmara Med J. 1993;6(3):110-5.