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Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting

Year 1994, Volume: 7 Issue: 1, 33 - 35, 01.01.1994

M. Erenus Ö. Leylek H. Canatay M.A. Akman Y. Göğüs

Abstract

The purpose of the present randomized, double blind placebo controlled study was to compare the effect of ondansetron, a 5 HT 3 subtype of serotonin receptor antagonist, with placebo, in preventing postoperative nausea and vomiting. A total of forty-nine patients undergoing total abdominal hysterectomy were assigned to the study. The patients received either 4 mg intravenous ondansetron or a matching placebo, prior to induction of anesthesia. The number of episodes of emesis and nausea were recorded at 1 hour, 4 hour and 8 hour after recovery from anesthesia. The nausea and womiting scores at 1h 4h and 8h in the ondansetron group were significantly lower than the placebo group (p<0.05). The incidence of the most frequently occuring side effects in the ondansetron group were headache in 15.38 % and dizziness in 7.7 % of the patients. In conclusion, ondansetron appears to be an effective agent in the prophylaxis of postoperative nausea and vomiting in gynecologic operations.

Keywords

Prophylaxis emesis ondansetron

References

  • Mathia WL, Bell SK, Leak WD. Effects of preoperative metoclopralde and droperidol on postoperative nauesa and vomiting in ambulatory surgery patients. Am Assoc nurse Anesth J 1988; 56:325-333.

Year 1994, Volume: 7 Issue: 1, 33 - 35, 01.01.1994

M. Erenus Ö. Leylek H. Canatay M.A. Akman Y. Göğüs

Abstract

References

  • Mathia WL, Bell SK, Leak WD. Effects of preoperative metoclopralde and droperidol on postoperative nauesa and vomiting in ambulatory surgery patients. Am Assoc nurse Anesth J 1988; 56:325-333.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

M. Erenus This is me

Ö. Leylek This is me

H. Canatay This is me

M.A. Akman This is me

Y. Göğüs This is me

Publication Date January 1, 1994
Published in Issue Year 1994 Volume: 7 Issue: 1

Cite

APA Erenus, M., Leylek, Ö., Canatay, H., Akman, M., et al. (1994). Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting. Marmara Medical Journal, 7(1), 33-35.
AMA Erenus M, Leylek Ö, Canatay H, Akman M, Göğüs Y. Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting. Marmara Med J. January 1994;7(1):33-35.
Chicago Erenus, M., Ö. Leylek, H. Canatay, M.A. Akman, and Y. Göğüs. “Single Dose Intravenous Ondansetron in the Prophylaxis of Postoperative Nausea and Vomiting”. Marmara Medical Journal 7, no. 1 (January 1994): 33-35.
EndNote Erenus M, Leylek Ö, Canatay H, Akman M, Göğüs Y (January 1, 1994) Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting. Marmara Medical Journal 7 1 33–35.
IEEE M. Erenus, Ö. Leylek, H. Canatay, M. Akman, and Y. Göğüs, “Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting”, Marmara Med J, vol. 7, no. 1, pp. 33–35, 1994.
ISNAD Erenus, M. et al. “Single Dose Intravenous Ondansetron in the Prophylaxis of Postoperative Nausea and Vomiting”. Marmara Medical Journal 7/1 (January 1994), 33-35.
JAMA Erenus M, Leylek Ö, Canatay H, Akman M, Göğüs Y. Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting. Marmara Med J. 1994;7:33–35.
MLA Erenus, M. et al. “Single Dose Intravenous Ondansetron in the Prophylaxis of Postoperative Nausea and Vomiting”. Marmara Medical Journal, vol. 7, no. 1, 1994, pp. 33-35.
Vancouver Erenus M, Leylek Ö, Canatay H, Akman M, Göğüs Y. Single dose intravenous ondansetron in the prophylaxis of postoperative nausea and vomiting. Marmara Med J. 1994;7(1):33-5.