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Erythropoietin in the treatment of anaemia of chronic renal failure

Year 1994, Volume: 7 Issue: 2, 54 - 58, 01.04.1994

Abstract

Human recombinant erythropoietin was administered subcutaneously to 26 chronic haemodialysis patients over a six month period, and the effect of erythropoiesis investigated. Initial therapy was 4000 units twice weekly with therapy titrated to individual response after 1 month. Mean EPO dosage was 150 ± 51 u/kg/week at the start of the study and 112 ± 50 u/kg/week at 6 months. The mean haemoglobin level rose from 6.7 ± 1.7 gr/dl at the start of treatment to 9.1 ± 1.9 gr/dl at 3 months (p<0.01) and 9.6 ± 1.9 gr/dl at 6 months. Simultaneously the mean haematocrit rose from 21 ± 4.8 to 28.3 ± 6.2 at 3 months (p<0.01) and 29.3 ± 4.6 at 6 months. Platelet count and white cell count were unaffected by therapy. Treatment failure occurred in 5 patients and seizures were seen in 4 patients. EPO therapy was not associated with increase in blood pressure.

References

  • Fyhraqist F, Rosen lof K, Qronhagen R C, et al. Is renin substrate an erythropoietin precursor? nature 1984; 308:649-652.
Year 1994, Volume: 7 Issue: 2, 54 - 58, 01.04.1994

Abstract

References

  • Fyhraqist F, Rosen lof K, Qronhagen R C, et al. Is renin substrate an erythropoietin precursor? nature 1984; 308:649-652.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

İ.ç. Özener This is me

R.a. Lawrence This is me

Ö. Ersöz This is me

E. Akoğlu This is me

Publication Date April 1, 1994
Published in Issue Year 1994 Volume: 7 Issue: 2

Cite

APA Özener, İ., Lawrence, R., Ersöz, Ö., Akoğlu, E. (1994). Erythropoietin in the treatment of anaemia of chronic renal failure. Marmara Medical Journal, 7(2), 54-58.
AMA Özener İ, Lawrence R, Ersöz Ö, Akoğlu E. Erythropoietin in the treatment of anaemia of chronic renal failure. Marmara Med J. April 1994;7(2):54-58.
Chicago Özener, İ.ç., R.a. Lawrence, Ö. Ersöz, and E. Akoğlu. “Erythropoietin in the Treatment of Anaemia of Chronic Renal Failure”. Marmara Medical Journal 7, no. 2 (April 1994): 54-58.
EndNote Özener İ, Lawrence R, Ersöz Ö, Akoğlu E (April 1, 1994) Erythropoietin in the treatment of anaemia of chronic renal failure. Marmara Medical Journal 7 2 54–58.
IEEE İ. Özener, R. Lawrence, Ö. Ersöz, and E. Akoğlu, “Erythropoietin in the treatment of anaemia of chronic renal failure”, Marmara Med J, vol. 7, no. 2, pp. 54–58, 1994.
ISNAD Özener, İ.ç. et al. “Erythropoietin in the Treatment of Anaemia of Chronic Renal Failure”. Marmara Medical Journal 7/2 (April 1994), 54-58.
JAMA Özener İ, Lawrence R, Ersöz Ö, Akoğlu E. Erythropoietin in the treatment of anaemia of chronic renal failure. Marmara Med J. 1994;7:54–58.
MLA Özener, İ.ç. et al. “Erythropoietin in the Treatment of Anaemia of Chronic Renal Failure”. Marmara Medical Journal, vol. 7, no. 2, 1994, pp. 54-58.
Vancouver Özener İ, Lawrence R, Ersöz Ö, Akoğlu E. Erythropoietin in the treatment of anaemia of chronic renal failure. Marmara Med J. 1994;7(2):54-8.