Nimodipine has no effects on ceftriaxone - induced epileptogenic focus in rabbits

Year 1995, Volume: 8 Issue: 1, 6 - 10, 01.01.1995

F. Turan S. Sadikoglu A. Dalgiç î. Bora M. Zarifoglu N. Balkır

Abstract

In this study antiepileptic effects of nimodipine (ND) on ceftriaxone - induced epileptogenic focus in twenty rabbits were analysed. After base - line EEG was recorded 3% ceftriaxone was administered topically under dura mater of left sensori-motor area. EEG recording was made at least for twenty minutes. ND was given intravenously in doses of 0.1 mg/kg for three minutes and EEG recording was continued for thirty minutes. The parameters used in EEG analysis were the number of spikes, spike and wave bursts per second and EEG scores evaluated in both the ipsilateral and contralateral focus. The number of spikes, spike and wave bursts per second decreased after ND in four rabbits (20%), but increased in four rabbits (20%). No changes were observed in the others (60%). The EEG scores showed no difference before and after ND. In the second step, diazepam was administered intravenously in dose of 0.5 mg/kg to twelve rabbits receiving ND. EEG findings and foci absolutely disappeared in four rabbits (33.3%) but in the others (66.7%) showed general depressing activity with minimal epileptic activity. The EEG scores of diazepam receiving group after ND decreased significantly (p<0.01). We conclude that ND is not effective on ceftriaxone - induced epileptogenic focus in rabbits.

Keywords

Nimodipine, Ca++ channel blocker, experimental focal epilepsy

References

• Meyer FB, Anderson RE, Sundt TM Jr. Anticonvulsant effects of dihydropyridine Ca2 + antagonists in electrocortical shock seizures. Epilepsia 1990; 31: 68-74.