Abstract
References
- Kayaalp O. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Vol 2, 5th ed. Ankara: Faryal Mat-San ve Ud. Şti, 1991: 1109-1115.
Abstract
We planned to investigate the effect of diltiazem on
urine volume, urine sodium (Na+) and potassium (K+) excretion and glomerular filtration rate (GFR). Twenty healthy men, aged between 23 and 36 (mean age: 29 ± 0.87) were examined. A double - blind placebo controlled study was completed by weekly intervals in 3 periods. In each period, first day no drug was given, the second day placebo, the third day diltiazem (30 mg or 60 mg) or placebo was given.
In the first 6 hour period following diltiazem 30 or 60 mg administration, increases in GFR (p<0.05), urine volume (p<0.01) and urine Na+ excretion were
significant (p<0.001), but increase in urine K+ excretion was not significant (p>0.05). In the next 18 hour period, we observed that diltiazem did not affect
the excretion of K+ urine volume and GFR (p> 0.05), but increased the excretion of Na+ (p<0.05).
Keywords
References
- Kayaalp O. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. Vol 2, 5th ed. Ankara: Faryal Mat-San ve Ud. Şti, 1991: 1109-1115.
Details
| Subjects | Clinical Sciences |
|---|---|
| Journal Section | Derleme |
| Authors | |
| Publication Date | January 1, 1995 |
| Published in Issue | Year 1995 Volume: 8 Issue: 1 |