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Antinociceptive effects of morphine and physostigmine in different inbred strains of mice

Year 1996, Volume: 9 Issue: 1, 7 - 10, 01.01.1996

A.n. Aslan K. Berkman B. Çırakoğlu Ş. Oktay

Abstract

Antinociceptive effects of morphine and physostigmine, alone or in combination were investigated in mice of BALB/C, C57BL/6 and CB6F1 strains. Morphine and physostigmine increased pain treshold in BALB/C and CB6F1 mice at a dose of 5 mg/kg and 0.1 mg/kg, respectively, whereas C57BL/6 mice were found to be less responsive to both agents. When a nonanalgesic dose of physostigmine (0.05 mg/kg) was combined with a nonanalgesic dose of morphine (2.5 mg/kg), a significant antinociceptive effect was observed in BALB/C and CB6F1 mice, but not in C57BL/6 strain. These results suggest that there is a significant influence of strain on cholinergic and opioid antinociception, and synergistic interaction between cholinergic and opioidergic systems also occur strain-dependently.

Keywords

Analgesia tail-flick morphine physostigmine BALB/C C57BL76 CB6F1

References

  • Mam RJ, Rnisely JS. Development of differences in the analgesia produced by the central cholinergic system. Develop Psychobiol 1986;20:345-354.

Year 1996, Volume: 9 Issue: 1, 7 - 10, 01.01.1996

A.n. Aslan K. Berkman B. Çırakoğlu Ş. Oktay

Abstract

References

  • Mam RJ, Rnisely JS. Development of differences in the analgesia produced by the central cholinergic system. Develop Psychobiol 1986;20:345-354.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

A.n. Aslan This is me

K. Berkman This is me

B. Çırakoğlu This is me

Ş. Oktay This is me

Publication Date January 1, 1996
Published in Issue Year 1996 Volume: 9 Issue: 1

Cite

APA Aslan, A., Berkman, K., Çırakoğlu, B., Oktay, Ş. (1996). Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Medical Journal, 9(1), 7-10.
AMA Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. January 1996;9(1):7-10.
Chicago Aslan, A.n., K. Berkman, B. Çırakoğlu, and Ş. Oktay. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal 9, no. 1 (January 1996): 7-10.
EndNote Aslan A, Berkman K, Çırakoğlu B, Oktay Ş (January 1, 1996) Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Medical Journal 9 1 7–10.
IEEE A. Aslan, K. Berkman, B. Çırakoğlu, and Ş. Oktay, “Antinociceptive effects of morphine and physostigmine in different inbred strains of mice”, Marmara Med J, vol. 9, no. 1, pp. 7–10, 1996.
ISNAD Aslan, A.n. et al. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal 9/1 (January 1996), 7-10.
JAMA Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. 1996;9:7–10.
MLA Aslan, A.n. et al. “Antinociceptive Effects of Morphine and Physostigmine in Different Inbred Strains of Mice”. Marmara Medical Journal, vol. 9, no. 1, 1996, pp. 7-10.
Vancouver Aslan A, Berkman K, Çırakoğlu B, Oktay Ş. Antinociceptive effects of morphine and physostigmine in different inbred strains of mice. Marmara Med J. 1996;9(1):7-10.