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2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells

Year 1996, Volume: 9 Issue: 1, 23 - 28, 01.01.1996

G. Hergenç K. Emerk

Abstract

Glucose transport into human peripheral lymphocytes, rat lymphocytes, and rat thymocytes were investigated using 2-deoxyglucose (2-DOG) in the transport studies. Our results showed rat thymocytes to have a high affinity and a low affinity system for transporting 2-DOG with Km values of

0.11 mM and 7.14 mM respectively. Both of the systems were inhibited by phloretin (0.1 mM), a specific inhibitor of carrier mediated transport. Human peripheral lymphocytes and rat lymphoctes transported 2-DOG with Km values of 5.26 mM and 3.57 mM respectively. While insulin had no effect on this transport in thymocytes and lymphocytes, it inhibited the efflux of 2-DOG from the cells.

Keywords

2-DOG uptake lymphocytes thymocytes transport insulin

References

  • Carruthers A. Facilitated diffusion of glucose. Physiol Reviews 1990:70:1135-1176.

Year 1996, Volume: 9 Issue: 1, 23 - 28, 01.01.1996

G. Hergenç K. Emerk

Abstract

References

  • Carruthers A. Facilitated diffusion of glucose. Physiol Reviews 1990:70:1135-1176.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

G. Hergenç This is me

K. Emerk This is me

Publication Date January 1, 1996
Published in Issue Year 1996 Volume: 9 Issue: 1

Cite

APA Hergenç, G., & Emerk, K. (1996). 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Medical Journal, 9(1), 23-28.
AMA Hergenç G, Emerk K. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J. January 1996;9(1):23-28.
Chicago Hergenç, G., and K. Emerk. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal 9, no. 1 (January 1996): 23-28.
EndNote Hergenç G, Emerk K (January 1, 1996) 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Medical Journal 9 1 23–28.
IEEE G. Hergenç and K. Emerk, “2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells”, Marmara Med J, vol. 9, no. 1, pp. 23–28, 1996.
ISNAD Hergenç, G. - Emerk, K. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal 9/1 (January 1996), 23-28.
JAMA Hergenç G, Emerk K. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J. 1996;9:23–28.
MLA Hergenç, G. and K. Emerk. “2-Deoxyglucose Transport in Human Peripheral Lymphocytes Rat Lymphocytes and Thymocytes; Effects of Insulin on 2-Deoxyglucose Transport in These Cells”. Marmara Medical Journal, vol. 9, no. 1, 1996, pp. 23-28.
Vancouver Hergenç G, Emerk K. 2-deoxyglucose transport in human peripheral lymphocytes rat lymphocytes and thymocytes; effects of insulin on 2-deoxyglucose transport in these cells. Marmara Med J. 1996;9(1):23-8.