Hepatic veno-occlusive disease after bone marrow transplantation

Year 1996, Volume: 9 Issue: 2, 0 - 0, 01.03.1996

C. Canpolat D. Başdemir

Abstract

In the first few weeks after bone marrow transplantation, a clinical syndrome characterized by hepatomegaly, jaundice, and fluid retention develops in 10 to 70% of patients. This syndrome is due to damage to endothelial cells, sinusoids, and hepatocytes in zone 3 of thejiver acinus. The proximate cause of the damage is cytoreductive therapy. This syndrome, often called veno-occlusive disease of the liver, can vary in severity from mild reversible disease to fatal disease associated with multiorgan failure

Keywords

Hepatic veno-occlusive disease, Bone marrow transplantation, Cytoreductive therapy

References

• Shu İman MM, McDonald OB, Matthews D, et al. An analysis of hepatic veno-occlusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology 1980/79:1178-91.