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The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia

Year 1997, Volume: 10 Issue: 2, 100 - 102, 01.03.1997

Abstract

Objective: It was reported that intensive immunosuppressive therapy is the current treatment of choice for patients with aplastic anemia who do not have histocompatible siblings or who are otherwise ineligible for alogenic bone marrow transplantation. We therefore designed a clinical study to establish the efficacy of intensive immunosuppressive therapy in these patients.

Methods: Ten patients with severe aplastic anemia were treated with Antithymocyte globulin (ATG) 15 mg/kg/d for 10 days in 4 hours infusion, Cyclosporine A (CsA) 10 mg/kg/d p.o initially and regulated according to the serum CsA level for 3-6 months and méthylprednisolone 1 mg/kg/d as a short infusion for 2 weeks.

Results: The hematologic response was achieved in 7 of the 10 patients, in a mean duration of 102.3 (30- 168) days. All of the responders are in continuing remission for a median of 25.2 (7-60) months. Three of the non-responders died of intercurrent infection.

Conclusion: In this study we achieved a high hematologic response with intensive immunosuppressive therapy as reported in the literature.

References

  • Thomas ED, Storb R, Fefer A, et al. Aplastic anaemia treated by marrow transplantation. Lancet 1972;1:284-286.
Year 1997, Volume: 10 Issue: 2, 100 - 102, 01.03.1997

Abstract

References

  • Thomas ED, Storb R, Fefer A, et al. Aplastic anaemia treated by marrow transplantation. Lancet 1972;1:284-286.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

A. Öztürk This is me

M. Sezer This is me

N. Üskent This is me

Publication Date March 1, 1997
Published in Issue Year 1997 Volume: 10 Issue: 2

Cite

APA Öztürk, A., Sezer, M., & Üskent, N. (1997). The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia. Marmara Medical Journal, 10(2), 100-102.
AMA Öztürk A, Sezer M, Üskent N. The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia. Marmara Med J. March 1997;10(2):100-102.
Chicago Öztürk, A., M. Sezer, and N. Üskent. “The Results of Intensive Immunosuppression With Antithymocyte Globulin and Cyclosporine a in Severe Aplastic Anemia”. Marmara Medical Journal 10, no. 2 (March 1997): 100-102.
EndNote Öztürk A, Sezer M, Üskent N (March 1, 1997) The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia. Marmara Medical Journal 10 2 100–102.
IEEE A. Öztürk, M. Sezer, and N. Üskent, “The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia”, Marmara Med J, vol. 10, no. 2, pp. 100–102, 1997.
ISNAD Öztürk, A. et al. “The Results of Intensive Immunosuppression With Antithymocyte Globulin and Cyclosporine a in Severe Aplastic Anemia”. Marmara Medical Journal 10/2 (March 1997), 100-102.
JAMA Öztürk A, Sezer M, Üskent N. The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia. Marmara Med J. 1997;10:100–102.
MLA Öztürk, A. et al. “The Results of Intensive Immunosuppression With Antithymocyte Globulin and Cyclosporine a in Severe Aplastic Anemia”. Marmara Medical Journal, vol. 10, no. 2, 1997, pp. 100-2.
Vancouver Öztürk A, Sezer M, Üskent N. The results of intensive immunosuppression with antithymocyte globulin and cyclosporine a in severe aplastic anemia. Marmara Med J. 1997;10(2):100-2.