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Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf

Year 1997, Volume: 10 Issue: 3, 129 - 134, 01.07.1997

Abstract

Objective: The effect of chronic carbamazepine (CBZ) therapy on regional blood flow (rCBF) was evaluated using single photon emission computed tomography (SPECT) with technetium-99m hexamethylpropyleneamineoxime.

Methods: Interictal SPECT scans and

electroencephalography (EEG) examinations in 13 (8 males, 5 females) children with partial epilepsy were performed twice before administering CBZ and between 4-12 months (8.00±2.23 months) after starting the therapy.

Results: Visual assessment of interictal SPECT images showed stable perfusion abnormalities in 9 of 11 cases who had regions of hypoperfusion in the first scans. Before CBZ therapy, EEG correlated well with SPECT in 9/11 patients in localizing focal abnormality and the rate of correlation was 7/11 during the therapy. By quantitative evaluation, no significant change of rCBF in all cerebral cortical regions except right inferior frontal (p<0.03) was found after initiation of CBZ therapy. Repeated SPECT scans done in 6 healthy volunteers at intervals of 6 to 10 months (7.20±3.45 months) demonstrated no significant change of rCBF.

Conclusion: Our results suggest that chronic CBZ therapy does not affect blood flow of the epileptogenic zone nor of the other parts of cerebral cortex. The absence of any effect due to chronic CBZ therapy may be related to the partial clinical improvement.

References

  • Ryding E, Rosen I, Elmquist D, Ingvar DH. SPECT measurement with 99m-Tc-f1M-PAO in focal epilepsy. J Cereb Blood Flow Metab 1988;8:595- 601
Year 1997, Volume: 10 Issue: 3, 129 - 134, 01.07.1997

Abstract

References

  • Ryding E, Rosen I, Elmquist D, Ingvar DH. SPECT measurement with 99m-Tc-f1M-PAO in focal epilepsy. J Cereb Blood Flow Metab 1988;8:595- 601
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

D. Türkdoğan This is me

Ç. Önsel This is me

E. Altıok This is me

E. Yalçın This is me

Publication Date July 1, 1997
Published in Issue Year 1997 Volume: 10 Issue: 3

Cite

APA Türkdoğan, D., Önsel, Ç., Altıok, E., Yalçın, E. (1997). Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf. Marmara Medical Journal, 10(3), 129-134.
AMA Türkdoğan D, Önsel Ç, Altıok E, Yalçın E. Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf. Marmara Med J. July 1997;10(3):129-134.
Chicago Türkdoğan, D., Ç. Önsel, E. Altıok, and E. Yalçın. “Effect of Carbamazepine Therapy on Cerebral Blood Flow in Children With Partial Epilepsyf”. Marmara Medical Journal 10, no. 3 (July 1997): 129-34.
EndNote Türkdoğan D, Önsel Ç, Altıok E, Yalçın E (July 1, 1997) Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf. Marmara Medical Journal 10 3 129–134.
IEEE D. Türkdoğan, Ç. Önsel, E. Altıok, and E. Yalçın, “Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf”, Marmara Med J, vol. 10, no. 3, pp. 129–134, 1997.
ISNAD Türkdoğan, D. et al. “Effect of Carbamazepine Therapy on Cerebral Blood Flow in Children With Partial Epilepsyf”. Marmara Medical Journal 10/3 (July 1997), 129-134.
JAMA Türkdoğan D, Önsel Ç, Altıok E, Yalçın E. Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf. Marmara Med J. 1997;10:129–134.
MLA Türkdoğan, D. et al. “Effect of Carbamazepine Therapy on Cerebral Blood Flow in Children With Partial Epilepsyf”. Marmara Medical Journal, vol. 10, no. 3, 1997, pp. 129-34.
Vancouver Türkdoğan D, Önsel Ç, Altıok E, Yalçın E. Effect of carbamazepine therapy on cerebral blood flow in children with partial epilepsyf. Marmara Med J. 1997;10(3):129-34.