Abdic regimen in relapsed or refractory hodgkin's disease: Results of gulhane military medical academy haydarpaşa training hospital

Year 1997, Volume: 10 Issue: 3, 135 - 137, 01.07.1997

A. Öztürk E.g. Kandemir O. Bilgi M. Yaylacı N. Uskent

Abstract

Objective: The aim of this study is to present the results of ABDIC regimen in patients with relapsed or refractory Hodgkin's disease treated at the Department of Hematology of Gülhane Military Medical Academy Haydarpaşa Training Hospital.

Methods: Twelve patients with relapsed or refractory Hodgkin's disease, who had been heavily pretreated, received Doxorubicine, Bleomycin, Dacarbazine, CCNU and Prednisone (ABDIC) regimen. There were 10 men, 2 women and mean age was 31.

Results: Complete response was achieved in one patient and 5 patients had partial response. Total response rate was 50% The patient who achieved complete response with ABDIC is alive and free of disease at 13 months. High dose chemotherapy with stem cell transplantation was performed in two patients with partial response and these patients are alive and free of disease at 6 and 11 months respectively. Remaining three partial responders died at 8, 10 and 13 months respectively.

Conclusion: ABDIC regimen is a well tolerated and effective regimen for relapsed or refractory Hodgkin's disease patients who received MOPP and ABVD regimen before.

Keywords

Hodgkin's disease, ABDIC regimen

References

• DeVita VT Jr., Simon RM, Hubbard SM, et al. Curability of advanced Hodgkin's disease with chemotherapy: long-term follow-up of MOPP- treated patients at the national Cancer Institute. Ann Intern Med 1980;92:587-595.