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A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia

Year 1997, Volume: 10 Issue: 4, 198 - 202, 01.10.1997

Abstract

Objective: We aimed to compare the efficacy and side effects of propofol, midazolam and alfentanil used for sedation during spinal anesthesia.

Methods: Thirty patients aged. 20-70 years, scheduled for inguinal hernia repair, appendectomy or transurethral resection were randomly assigned to three groups (n=10). The patients were given 1.25 mg/kg propofol i.v. in group I, 1.8 |ig/kg alfentanil i.v. in group II and 0.1 mg/kg midazolam i.v. in group III prior performing spinal anesthesia. For maintenance of sedation propofol infusion of 3 mg/kg/h in group I,alfentanil infusion of 40 Jlg/kg/h in group II and midazolam infusion of 0.1 mg/kg/h in group III were started. The infusion rates were adjusted to maintain an appropriate sedation level. In all patients mean arterial pressure (MAP), heart rate (HR), oxygen saturation (Sp02), end tidal carbondioxide (ETC02) and respiratory rate (RR) were recorded.

Results: In propofol group; while MAP and HR decreased significantly after bolus dose, the sedation level 2 was achieved within 5 minutes (p<0.05). In alfentanil group; while HR, MAP and RR decreased and ETC02 increased significantly (p<0.05), the desired sedation level was not achieved. In midazolam group; the sedation level 2 was achieved at 15th minute and MAP, Sp02, HR and RR decreased significantly (p<0.05).

Conclusion: We conclude that propofol is the most appropriate agent for sedation during spinal anesthesia.

References

  • Mackenzie M.Intravenous anesthesia and
  • sedation for regional anesthesia. In: Kay B, ed. Total Intravenous Anaesthesia, 2 nd ed, Amsterdam: Elsevier Science Publishers,
  • 1991:285-321.
Year 1997, Volume: 10 Issue: 4, 198 - 202, 01.10.1997

Abstract

References

  • Mackenzie M.Intravenous anesthesia and
  • sedation for regional anesthesia. In: Kay B, ed. Total Intravenous Anaesthesia, 2 nd ed, Amsterdam: Elsevier Science Publishers,
  • 1991:285-321.
There are 3 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

T. Umuroğlu This is me

Z. Eti This is me

F.Y. Gögüş This is me

Publication Date October 1, 1997
Published in Issue Year 1997 Volume: 10 Issue: 4

Cite

APA Umuroğlu, T., Eti, Z., & Gögüş, F. (1997). A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia. Marmara Medical Journal, 10(4), 198-202.
AMA Umuroğlu T, Eti Z, Gögüş F. A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia. Marmara Med J. October 1997;10(4):198-202.
Chicago Umuroğlu, T., Z. Eti, and F.Y. Gögüş. “A Comparison of Propofol, Alfentanil and Midazolam for Sedation During Spinal Anesthesia”. Marmara Medical Journal 10, no. 4 (October 1997): 198-202.
EndNote Umuroğlu T, Eti Z, Gögüş F (October 1, 1997) A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia. Marmara Medical Journal 10 4 198–202.
IEEE T. Umuroğlu, Z. Eti, and F. Gögüş, “A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia”, Marmara Med J, vol. 10, no. 4, pp. 198–202, 1997.
ISNAD Umuroğlu, T. et al. “A Comparison of Propofol, Alfentanil and Midazolam for Sedation During Spinal Anesthesia”. Marmara Medical Journal 10/4 (October 1997), 198-202.
JAMA Umuroğlu T, Eti Z, Gögüş F. A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia. Marmara Med J. 1997;10:198–202.
MLA Umuroğlu, T. et al. “A Comparison of Propofol, Alfentanil and Midazolam for Sedation During Spinal Anesthesia”. Marmara Medical Journal, vol. 10, no. 4, 1997, pp. 198-02.
Vancouver Umuroğlu T, Eti Z, Gögüş F. A comparison of propofol, alfentanil and midazolam for sedation during spinal anesthesia. Marmara Med J. 1997;10(4):198-202.