VISUAL EVOKED POTENTIALS IN HEMODIALYSIS PATIENTS

Year 1999, Volume: 12 Issue: 3, 122 - 125, 03.12.2016

Aytül Mutlu Münevver Çelik Fatma Karakullukçu Hulki Forta

Abstract

Objective: In this study, the subclinical involvement in visual pathways were investigated by means of pattern reversal visual evoked potentials (PVEPs) in chronic hemodialysis (HD) patients and the short-term effects of HD on PVEPs were evaluated.
Methods: PVEPs were recorded in 20 healthy subjects and in 18 patients who had no neurological and/or ophthalmological involvement on clinical examination. In patient group PVEPs were performed 2 hours and 26 hours after two sets of HD performed 4 months apart. Urea, creatinine and electrolytes were measured immediately before each PVEP examination. Pathological tresholds for individual P100 values were set at 3SD above the control means for both absolute latencies and interocular latency differences.
Results: Abnormalities regarding the P100 latencies could be detected in 23.5% of the patients. When compared the group mean values of patients with normal PVEPs, P100 latencies did not reveal any significant change between two tests in each admission. P100 amplitude was significantly higher in 2nd hour examination than in 26th hour examination only at second admission. There was no relationship between amplitudes and biochemical measurements. P100 latencies showed a significant correlation with urea measurements in one occasion and with creatinine in another occasion.
Conclusion: Standard PVEP examination can be beneficial in detecting subclinical abnormalities in HD patients. HD could have short-term effects on P100 amplitudes though this effect could not be established consistently and did not correlate with biochemical parameters.
Key Words: Hemodialysis, Visual evoked
potentials

References

• Brown JJ, Sufit RL, Sollinger flW. Visual evoked potential changes following renal transplantation. Electroenceph Clin rieurophysiol I987;66:101-107.
• De Weerd AW, riihom J, Rozeman CAM, et al. ft reflexes as a measure for uremic polyneuropathy. A longitudinal study in patients treated with dialysis or renal transplantation. Electroenceph Clin rieurophysiol 1994;93:276-280.
• Lowitzsch K, Gohring U, flecking Eli. Refractory period, sensory conduction velocity and visual evoked potentials before and after haemodialysis. J rieurol fieurosurg Psychiatry 1981 ;44:121-128.
• Storch RL, Storch S, London R, Pordy WT. Differences in pattern visual evoked potential (PVEP) between hemodialysis and peritoneal dialysis patients. Electroenceph Clin rieurophysiol 1992;23:169-176.
• Suppiej A, Caara G, Boniver C, Pozzan GB, Montini G. Somatosensory pathway dysfunction in uremic children. Brain Develop 1991; 13:238-24 I.
• flamed ML, Win ward EK, Glaser JS, Schatz MJ. Optic neuropathy in uremia. Am J Ophthalmol 1989;108:30-35.
• Kuba M, Peregrin J, Vit F, flanusova I, Erben J. Pattern-reversal visual evoked potentials in patients with chronic renal insufficiency. Electroenceph Clin rieurophysiol 1983;56:438-442.
• Lewis EG, O'Meill WM, Dustman RE, Beck EC. Temporal effects of haemodialysis on measures of neural efficiency. Kidney Int 1980;17:357-363.
• Lewis EG, Dustman RE, Beck EC. Visual and somatosensory evoked potential characteristics of patients undergoing hemodialysis and kidney transplantation. Electroenceph Clin rieurophysiol 1978;44:223-231.
• Rossini PM, Pirchio M, Treviso M, Gambi D, Di Paolo B, Albertazzi A. Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects. Electroenceph Clin rieurophysiol 1981 ,-52:435-444.
• Chiappa Kfl. Pattern-shift visual evoked potentials:
• Interpretation. In: Chiappa Kfl, ed. Evoked
• potentials in clinical medicine, new York, Raven Press: 1990:111-154.
• Pagani C, Bazzi C, Arriga G, Venturin'! CT, D Arnica GD. Evoked potential (VEPs and BAEP's) in a large cohort of short- and long-term haemodiatysed patients. nephrol Dial Transplant 1993:8:1 124- 1128.
• Ducati A, Cattarelli D, Cenzato M, et al. Changes in visual evoked potentials in children on chronic dialysis treatment. Childs Merv System 1985; 1:282- 287.
• Teschan PE, Ginn HE, Bourne JR, et al. Quantitative indices of clinical uraemia. Kidney Int 1979; 15:676- 697.
• Yu YL, Cheng IKP, Chang CM, et al. /t multimodal neurophysiological assessment in terminal renal failure. Acta rieurol Scand 1991;83:89-95.