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THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN

Year 1999, Volume: 12 Issue: 2, 63 - 66, 03.12.2016

Mithat Erenus Ulun Uluğ Alin Başgül

Abstract

Objective: The purpose of this prospective study is to investigate the impact of adding active vitamin D metabolite to hormone replacement therapy (HRT) in the treatment of osteoporosis in early postmenopausal women.
Methods: Fifty-two naturally postmenopausal women receiving either 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone acetate daily for 12 months or 0.50 pgr one alpha cholecalciferol in addition to 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone acetate daily for 12 months.
Results: Bone mass density (BMD) increases significantly in both treatment groups at 12 months not only in proximal femur but in the lumbar spine as well. In the HRT + alpha calcidiol group, the percentage of change in BMD for the proximal femur was 17.32 ± 22.41 and 15.02 ± 10.05 for the lumbar spine. In the HRT alone treatment group the percentage of change in BMD was 12.21 ± 12.81 and 9.44 ± 8.01 for the proximal femur and the lumbar spine respectively.
Conclusion: Addition of vitamin D metabolite seemed to potentiate the BMD elevating effect of HRT even though the positive trend in the BMD change was not statistically significant in one year.
Key Words: Alpha calcidiol, Bone Density, Hormone Replacement Therapy.

References

  • Quesada- Gomez JM, Alanso J, Bovillan R. Vitamin D insufficiency as a determinant of hip fractures. Osteoporos Int I996;(supp !3):42-47.
  • Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin Dj and calcium to prevent hip fractures in elderly women. b Engl J Med 1992;327:1637-1642.
  • Lips F, Graafmans WC, Ooms ME, et al. The effect of vitamin D supplementation on the incidence of hip fractures in elderly people. J Bone Miner Res I994;(suppl I ¡.abstract 112.
  • Slovik DM, Adams JS, beer RM, flolick MF, Potts JT, Jr. Deficient production of 1,25 dihydroxy vitamin D in elderly osteoporotic patients, b. Engl J Med 1981;305:372-374.
  • lshibe M, bojima T, Ishiabishi T, et al. I 73- estradiol increases the receptor number and modulates the action of 1,25 dihydroxy vitamin Dj in human
  • osteosarcoma derived osteoblast like celts. C.alc.if Tissue Int 1995:57:430-435.
  • banjo M, Ichikawa F, fliguchi Y, et al. The mechanism of action, metabolism and distribution of I alpha hydroxycholecalciferol in bone. Bone Miner 1992;17:99-102.
  • Imai Y, Fukase M, Mori S, et al. Effect of long term administration of alfa calcidiol on bone mineral density in involutional osteoporosis. Fourth international symposium on osteoporosis and consensus development conference, Hong Kong. Abstracts: 1993:114.
  • Heikkinen AM, Parviainen M, biskannen L, et al. Biochemical bone markers and bone mineral density during postmenopausal hormone replacement therapy with and without vitamin D: /l prospective controlled randomized study. J Clin Endocrinol Metab 1997;82:2476-2482
  • Menczel J, Foldes J, Steinberg R. et al. Alfa calcidiol (alphaD3) and calcium in osteoporosis. Clin OrtopiUnited States) 1994:300:24 1-247.
  • Francis RM, Peacock M, Taylor GA, Storer JH, bordin BE. Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci 1984;66:103-107.
  • Francis RM, Boyle IT, Moniz C, et al. A comparison of the effects of alfa calcidiol treatment and vitamin D supplementation on calcium absorption in elderly women with osteoporosis. In: borman AW, Boullion R, Thomasset M, eds. Vitamin D. A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications, binth Workshop on Vitamin D, Orlando, Florida. Proceedings: 1994:850-851.
  • Komulainen M, Tuppurainen MT, Kroger 11, et al. Vit
  • D and HRT: bo benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5 year randomized placebo controlled study: Osteoporos Int
  • ;7:126-132.
  • Tuppurainen MT, Komulainen M, Kroger II, et al. Does vitamin D strenghten the increase in femoral neck BMD is osteoporotic women treated with estrogen? Osteoporos Int 1998;7:32-38.

Year 1999, Volume: 12 Issue: 2, 63 - 66, 03.12.2016

Mithat Erenus Ulun Uluğ Alin Başgül

Abstract

References

  • Quesada- Gomez JM, Alanso J, Bovillan R. Vitamin D insufficiency as a determinant of hip fractures. Osteoporos Int I996;(supp !3):42-47.
  • Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin Dj and calcium to prevent hip fractures in elderly women. b Engl J Med 1992;327:1637-1642.
  • Lips F, Graafmans WC, Ooms ME, et al. The effect of vitamin D supplementation on the incidence of hip fractures in elderly people. J Bone Miner Res I994;(suppl I ¡.abstract 112.
  • Slovik DM, Adams JS, beer RM, flolick MF, Potts JT, Jr. Deficient production of 1,25 dihydroxy vitamin D in elderly osteoporotic patients, b. Engl J Med 1981;305:372-374.
  • lshibe M, bojima T, Ishiabishi T, et al. I 73- estradiol increases the receptor number and modulates the action of 1,25 dihydroxy vitamin Dj in human
  • osteosarcoma derived osteoblast like celts. C.alc.if Tissue Int 1995:57:430-435.
  • banjo M, Ichikawa F, fliguchi Y, et al. The mechanism of action, metabolism and distribution of I alpha hydroxycholecalciferol in bone. Bone Miner 1992;17:99-102.
  • Imai Y, Fukase M, Mori S, et al. Effect of long term administration of alfa calcidiol on bone mineral density in involutional osteoporosis. Fourth international symposium on osteoporosis and consensus development conference, Hong Kong. Abstracts: 1993:114.
  • Heikkinen AM, Parviainen M, biskannen L, et al. Biochemical bone markers and bone mineral density during postmenopausal hormone replacement therapy with and without vitamin D: /l prospective controlled randomized study. J Clin Endocrinol Metab 1997;82:2476-2482
  • Menczel J, Foldes J, Steinberg R. et al. Alfa calcidiol (alphaD3) and calcium in osteoporosis. Clin OrtopiUnited States) 1994:300:24 1-247.
  • Francis RM, Peacock M, Taylor GA, Storer JH, bordin BE. Calcium malabsorption in elderly women with vertebral fractures: evidence for resistance to the action of vitamin D metabolites on the bowel. Clin Sci 1984;66:103-107.
  • Francis RM, Boyle IT, Moniz C, et al. A comparison of the effects of alfa calcidiol treatment and vitamin D supplementation on calcium absorption in elderly women with osteoporosis. In: borman AW, Boullion R, Thomasset M, eds. Vitamin D. A pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications, binth Workshop on Vitamin D, Orlando, Florida. Proceedings: 1994:850-851.
  • Komulainen M, Tuppurainen MT, Kroger 11, et al. Vit
  • D and HRT: bo benefit additional to that of HRT alone in prevention of bone loss in early postmenopausal women. A 2.5 year randomized placebo controlled study: Osteoporos Int
  • ;7:126-132.
  • Tuppurainen MT, Komulainen M, Kroger II, et al. Does vitamin D strenghten the increase in femoral neck BMD is osteoporotic women treated with estrogen? Osteoporos Int 1998;7:32-38.
There are 16 citations in total.

Details

Journal Section Original Research
Authors

Mithat Erenus This is me

Ulun Uluğ This is me

Alin Başgül This is me

Publication Date December 3, 2016
Published in Issue Year 1999 Volume: 12 Issue: 2

Cite

APA Erenus, M., Uluğ, U., & Başgül, A. (2016). THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN. Marmara Medical Journal, 12(2), 63-66.
AMA Erenus M, Uluğ U, Başgül A. THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN. Marmara Med J. June 2016;12(2):63-66.
Chicago Erenus, Mithat, Ulun Uluğ, and Alin Başgül. “THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN”. Marmara Medical Journal 12, no. 2 (June 2016): 63-66.
EndNote Erenus M, Uluğ U, Başgül A (June 1, 2016) THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN. Marmara Medical Journal 12 2 63–66.
IEEE M. Erenus, U. Uluğ, and A. Başgül, “THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN”, Marmara Med J, vol. 12, no. 2, pp. 63–66, 2016.
ISNAD Erenus, Mithat et al. “THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN”. Marmara Medical Journal 12/2 (June 2016), 63-66.
JAMA Erenus M, Uluğ U, Başgül A. THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN. Marmara Med J. 2016;12:63–66.
MLA Erenus, Mithat et al. “THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN”. Marmara Medical Journal, vol. 12, no. 2, 2016, pp. 63-66.
Vancouver Erenus M, Uluğ U, Başgül A. THE IMPACT OF VITAMIN D3 METABOLITE TO HORMONE REPLACEMENT THERAPY ON BONE DENSITY IN EARLY POSTMENOPAUSAL WOMEN. Marmara Med J. 2016;12(2):63-6.