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THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON'S DISEASE PATIENTS

Year 2000, Volume: 13 Issue: 3, 148 - 152, 03.12.2016

Dilek İnce Günal Kerim Nurichalichi Neşe Tuncer Nural Bekiroğlu Sevinç Aktan

Abstract

Objective: Recently described nonmotor
fluctuations may cause disability in Parkinson's disease patients. These fluctuations are generally grouped as sensory, autonomic and cognitive/psychiatric. The clinical spectrum and frequency of these symptoms among patients with fluctuating Parkinson's disease are unknown.
Methods: We studied the correlation of nonmotor fluctuations with motor symptoms and determined the effect of age at disease onset, duration of disease, dosage and duration of levodopa treatment to the occurrence of nonmotor fluctuations.
Results: The statistical analysis showed a positive correlation of all above criteria with sensory and autonomic fluctuations. Whereas, cognitive-psychiatric fluctuations were found to be only correlated with the duration of levodopa usage. The nonmotor fluctuations included in the study were observed during "on" period as well as "off" and "end dose off" periods.
Conclusion: The variability of nonmotor fluctuations in clinical presentation and coappearance of these fluctuations with different types of motor fluctuations were considered as the effect of other neurotransmitter systems
acting syncronously with dopamine. In this study, we determined the high risk factors for nonmotor fluctuations in patients with Parkinson’s disease.
Key Words: Parkinson's disease, Nonmotor, fluctuations, Dopamine, Levodopa

References

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  • Poewe Wfl. Clinical aspects of motor fluctuations in patients with Parkinsons disease, neurology 1994;44(suppl 6):6-9.
  • flillen ME, Sage Jl. nonmotor fluctuations in patients with Parkinsons disease, neurology 1996,47:1180-1 183.
  • Qoetz CG, Lutge J, Tanner CM. Autonomic dysfunction in Parkinson s disease, neurology 1996;36:73-75.
  • Langston JW, Porno LS. Hypothalamus in Parkinsons disease. Ann neurol 1978;3:129- 133.
  • Olanow CW, Holler WC. An algoritm for the
  • management of Parkinson s disease.
  • Treatment guidelines. neurology
  • ;50(suppl 3):23-30.
  • Routh LC, Black JL, Ahlshog JE. Parkinson s disease complicated with anxiety. Mayo Clin Proc 1987;62:733-735.
  • Vasquez A, Jimenez EJ, Garcia-Ruiz P. Panic attacks in Parkinsons disease. Acta neurol Scand 1993;87:14-18.
  • Delis D, Direnfeld L, Alexander MP, Kaplan E.
  • Cognitive fluctuations associated with on-off phenomenon in Parkinsons disease,
  • neurology 1982;32:1049-1052.
  • Siemers ER, Shekhar A, Quaid H, Dickson H. Anxiety and motor performance in Parkinson s disease. Mov Disord 1993;8:501-506.
  • nissenbaum H, Quinn HP, Brown RG, Toone B, Gotham AM, Marsden CD. Mood swings associated with the "on-off phenomenon in Parkinson s disease. Psychol Med 1987;17:899-904.
  • Sage Jl, Mark MH. Basic mechanism of motor fluctuations, neurology 1994;44(suppl 6): 10- 14.

Year 2000, Volume: 13 Issue: 3, 148 - 152, 03.12.2016

Dilek İnce Günal Kerim Nurichalichi Neşe Tuncer Nural Bekiroğlu Sevinç Aktan

Abstract

References

  • Quinn HP. Classification of fluctuations in patients with Parkinson s disease, neurology 1988;51 (suppl 2), 25-29.
  • Poewe Wfl. Clinical aspects of motor fluctuations in patients with Parkinsons disease, neurology 1994;44(suppl 6):6-9.
  • flillen ME, Sage Jl. nonmotor fluctuations in patients with Parkinsons disease, neurology 1996,47:1180-1 183.
  • Qoetz CG, Lutge J, Tanner CM. Autonomic dysfunction in Parkinson s disease, neurology 1996;36:73-75.
  • Langston JW, Porno LS. Hypothalamus in Parkinsons disease. Ann neurol 1978;3:129- 133.
  • Olanow CW, Holler WC. An algoritm for the
  • management of Parkinson s disease.
  • Treatment guidelines. neurology
  • ;50(suppl 3):23-30.
  • Routh LC, Black JL, Ahlshog JE. Parkinson s disease complicated with anxiety. Mayo Clin Proc 1987;62:733-735.
  • Vasquez A, Jimenez EJ, Garcia-Ruiz P. Panic attacks in Parkinsons disease. Acta neurol Scand 1993;87:14-18.
  • Delis D, Direnfeld L, Alexander MP, Kaplan E.
  • Cognitive fluctuations associated with on-off phenomenon in Parkinsons disease,
  • neurology 1982;32:1049-1052.
  • Siemers ER, Shekhar A, Quaid H, Dickson H. Anxiety and motor performance in Parkinson s disease. Mov Disord 1993;8:501-506.
  • nissenbaum H, Quinn HP, Brown RG, Toone B, Gotham AM, Marsden CD. Mood swings associated with the "on-off phenomenon in Parkinson s disease. Psychol Med 1987;17:899-904.
  • Sage Jl, Mark MH. Basic mechanism of motor fluctuations, neurology 1994;44(suppl 6): 10- 14.
There are 17 citations in total.

Details

Journal Section Original Research
Authors

Dilek İnce Günal This is me

Kerim Nurichalichi This is me

Neşe Tuncer This is me

Nural Bekiroğlu This is me

Sevinç Aktan This is me

Publication Date December 3, 2016
Published in Issue Year 2000 Volume: 13 Issue: 3

Cite

APA Günal, D. İ., Nurichalichi, K., Tuncer, N., Bekiroğlu, N., et al. (2016). THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS. Marmara Medical Journal, 13(3), 148-152.
AMA Günal Dİ, Nurichalichi K, Tuncer N, Bekiroğlu N, Aktan S. THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS. Marmara Med J. June 2016;13(3):148-152.
Chicago Günal, Dilek İnce, Kerim Nurichalichi, Neşe Tuncer, Nural Bekiroğlu, and Sevinç Aktan. “THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS”. Marmara Medical Journal 13, no. 3 (June 2016): 148-52.
EndNote Günal Dİ, Nurichalichi K, Tuncer N, Bekiroğlu N, Aktan S (June 1, 2016) THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS. Marmara Medical Journal 13 3 148–152.
IEEE D. İ. Günal, K. Nurichalichi, N. Tuncer, N. Bekiroğlu, and S. Aktan, “THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS”, Marmara Med J, vol. 13, no. 3, pp. 148–152, 2016.
ISNAD Günal, Dilek İnce et al. “THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS”. Marmara Medical Journal 13/3 (June 2016), 148-152.
JAMA Günal Dİ, Nurichalichi K, Tuncer N, Bekiroğlu N, Aktan S. THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS. Marmara Med J. 2016;13:148–152.
MLA Günal, Dilek İnce et al. “THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS”. Marmara Medical Journal, vol. 13, no. 3, 2016, pp. 148-52.
Vancouver Günal Dİ, Nurichalichi K, Tuncer N, Bekiroğlu N, Aktan S. THE CLINICAL PROFILE OF NONMOTOR FLUCTUATIONS IN PARKINSON’S DISEASE PATIENTS. Marmara Med J. 2016;13(3):148-52.