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COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity

Year 2001, Volume: 14 Issue: 3, 169 - 172, 03.12.2016

Abstract

Objective: Psychiatric evaluation of 50 essential tremor (ET) patients was performed to determine the coexistent psychopathologies. The patients with positive psychopathologies were intended to treat by appropriate medication to demonstrate a positive effect of the treatment to tremor severity.
Methods: Symptom check list (SCL - 90R) and structural clinical interview-nonpatient (SCID-NP) were used as screening tests for psychopathologic symptoms. The patients with positive psychiatric findings according to DSM IV criteria were asked to use appropriate medication for 6 weeks in addition to their antitremor drugs. Alprazolam 0.75 mg daily was used for generalized anxiety disorder and social phobia, and sertraline 50 mg daily was given for affective disorder. Tremor severity was assessed by a standard scale before and after treatment.
Results: The results revealed the presence of anxiety disorder in 42 %, social phobia in 18 %, and affective disorder in 16 % of the patients. Administration of alprazolam to patients with anxiety disorders demonstrated a statistically significant improvement in tremor severity (p<0.05), however, in patients with social phobia and affective disorders no significant
improvement was observed after alprazolam or sertraline treatment, respectively.
Conclusion: Although the present study lacked a post-treatment psychiatric evaluation and had a limited study period of 6 weeks to identify the effect of present psychopathology on tremor severity, the observed frequent coexistence of psychopathologies and ET was quite remarkable. The results reinforced the positive effect of alprazolam on tremor control of ET patients with anxiety disorder. However, we could not demonstrate a significant improvement in tremor severity following treatment in ET patients having social phobia or dysthimic symptoms.
Key Words: Essential tremor, Psychopathology, Treatment, Coexistent

References

  • Holler WC, Busenbark KL. Essential tremor. In: Watts KL, Holler WC, eds. Movement Disorders. NY: McGraw Hill Companies, 1997:365-386.
  • Deuschl G, Bain P, Brin M. Ad Hoc Scientific Committee. Consensus statement of the Movement Disorder Society on tremor. Mov Disord 1998; 13 (suppl 3): 2-23.
  • Derogatis LR. SCL 90R, administration, scoring and procedures manual-1 for the R(evised) version. Baltimore, MD: Johns Hopkins University School of Medicine, 1977.
  • DSM IV: Diagnostic and Statistical Manual of
  • Mental Disorders (Fourth Edition). Washington: American Psychiatric
  • Association, 1994.
  • Schroeder D, Nasrallah HA. High alcoholism rate in essential tremor patients. Am J Psychiatry 1982; 139: 1471-1473.
  • Holler WC. Alcholism in essential tremor. Neurology 1983; 33: 1074-1076.
  • Huber SJ, Paulson G W. Efficacy of alprazolam for essential tremor. Neurology 1988; 38: 241-243.
  • Ince D, Aktan S. New therapeutic alternatives
  • for essential tremor: Alprazolam and
  • acetazolamide ( A placebo controlled doubleblind study). Mov Disord 1994; 9 (suppl I) : 23.
  • Bain PG, Findley LJ, Thompson PD. A study of hereditary essential tremor. Brain 1994; 11 7: 805-824.
  • Holler WC, Busenbark HL, Miner H. The relationship of essential tremor to other movement disorders: Report of 678 patients. Essential tremor study group. Ann Neurol 1994; 35: 717-723.
  • 1. Scheidt CE, Schuller B, Rayki O, Hommerell G, Deusch G. Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm. Neurology 1996; 47: 43-45.
Year 2001, Volume: 14 Issue: 3, 169 - 172, 03.12.2016

Abstract

References

  • Holler WC, Busenbark KL. Essential tremor. In: Watts KL, Holler WC, eds. Movement Disorders. NY: McGraw Hill Companies, 1997:365-386.
  • Deuschl G, Bain P, Brin M. Ad Hoc Scientific Committee. Consensus statement of the Movement Disorder Society on tremor. Mov Disord 1998; 13 (suppl 3): 2-23.
  • Derogatis LR. SCL 90R, administration, scoring and procedures manual-1 for the R(evised) version. Baltimore, MD: Johns Hopkins University School of Medicine, 1977.
  • DSM IV: Diagnostic and Statistical Manual of
  • Mental Disorders (Fourth Edition). Washington: American Psychiatric
  • Association, 1994.
  • Schroeder D, Nasrallah HA. High alcoholism rate in essential tremor patients. Am J Psychiatry 1982; 139: 1471-1473.
  • Holler WC. Alcholism in essential tremor. Neurology 1983; 33: 1074-1076.
  • Huber SJ, Paulson G W. Efficacy of alprazolam for essential tremor. Neurology 1988; 38: 241-243.
  • Ince D, Aktan S. New therapeutic alternatives
  • for essential tremor: Alprazolam and
  • acetazolamide ( A placebo controlled doubleblind study). Mov Disord 1994; 9 (suppl I) : 23.
  • Bain PG, Findley LJ, Thompson PD. A study of hereditary essential tremor. Brain 1994; 11 7: 805-824.
  • Holler WC, Busenbark HL, Miner H. The relationship of essential tremor to other movement disorders: Report of 678 patients. Essential tremor study group. Ann Neurol 1994; 35: 717-723.
  • 1. Scheidt CE, Schuller B, Rayki O, Hommerell G, Deusch G. Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm. Neurology 1996; 47: 43-45.
There are 15 citations in total.

Details

Journal Section Photo Quiz
Authors

İpek Akman This is me

Gonca İmir This is me

Eren Özek This is me

Nejat Ceyhan This is me

Publication Date December 3, 2016
Published in Issue Year 2001 Volume: 14 Issue: 3

Cite

APA Akman, İ., İmir, G., Özek, E., Ceyhan, N. (2016). COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity. Marmara Medical Journal, 14(3), 169-172.
AMA Akman İ, İmir G, Özek E, Ceyhan N. COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity. Marmara Med J. June 2016;14(3):169-172.
Chicago Akman, İpek, Gonca İmir, Eren Özek, and Nejat Ceyhan. “COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The Effect of Pharmacological Treatment of Coexistent Pathologies to Tremor Severity”. Marmara Medical Journal 14, no. 3 (June 2016): 169-72.
EndNote Akman İ, İmir G, Özek E, Ceyhan N (June 1, 2016) COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity. Marmara Medical Journal 14 3 169–172.
IEEE İ. Akman, G. İmir, E. Özek, and N. Ceyhan, “COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity”, Marmara Med J, vol. 14, no. 3, pp. 169–172, 2016.
ISNAD Akman, İpek et al. “COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The Effect of Pharmacological Treatment of Coexistent Pathologies to Tremor Severity”. Marmara Medical Journal 14/3 (June 2016), 169-172.
JAMA Akman İ, İmir G, Özek E, Ceyhan N. COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity. Marmara Med J. 2016;14:169–172.
MLA Akman, İpek et al. “COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The Effect of Pharmacological Treatment of Coexistent Pathologies to Tremor Severity”. Marmara Medical Journal, vol. 14, no. 3, 2016, pp. 169-72.
Vancouver Akman İ, İmir G, Özek E, Ceyhan N. COEXISTENT PSYCHOPATHOLOGIES IN ESSENTIAL TREMOR PATIENTS: The effect of pharmacological treatment of coexistent pathologies to tremor severity. Marmara Med J. 2016;14(3):169-72.